Millipore Sigma Pellicon 3 Cassettes Installation And User Manual Download Page 14

Pellicon

®

 3 Cassettes Installation and User Guide 

14

Troubleshooting

Symptom

Possible Cause

Remedy

Integrity test 

failure or low 

retention

Areas of membrane 

incompletely wetted

Repeat Flushing 

Procedure. Flush with 

water, retest

Manifold adapter plate 

not  

installed

Install manifold 

adapter plate

Inadequate pump 

capacity

Use larger pump when 

wetting filters

Compression of filter 

stack inadequate

Inspect threads, 

nuts and tie rods and 

system compression.
Torque unit again; 

retest. Increase torque 

if necessary.

Temperature change 

since last time holder 

was torqued

Torque unit again; 

retest

Chemical compatibility 

problem

Review chemical 

compatibility of filter. 

Replace filter.

Damage to membrane 

or cassette

Visually inspect filter, 

replace as needed

Improper membrane 

selection

Contact Technical 

Service.

Low NWP 

Value

System not vented 

properly

Ensure system is 

vented so that air is 

removed.

System and cassette 

not completely flushed

Flush system and 

cassette.

System and cassette 

not completely cleaned

Clean system and 

cassette.

Symptom

Possible Cause

Remedy

High NWP

Damage to membrane 

or cassette

Integrity test cassette

System and cassette 

over pressurized

Reduce system 

pressure

Worn cassette

Replace cassette

Multiple 

leaks in filter 

stack

Improper torque or 

compressive force

Check torque 

procedure, retorque. 

Check for dirt or 

corrosion on tie rods 

or bolts

Tube fitting 

leaks

Tube/fitting cracked

Inspect, replace part

NPT fitting not 

wrapped

Remove old tape, re-

tape adequately with 

PTFE tape

End of tubing not cut 

squarely

Cut tube square and 

reinstall

Missing O-ring or 

ferrule on fittings of 

defective sanitary 

gasket

Replace missing 

component, gasket, or 

entire fitting

Loose clamp

Tighten clamp

Oversized clamp

Replace clamp with 

smaller diameter 

clamp

Leak 

between 

holder, filters

Dirt or debris in filter

Disassemble stack, 

remove stack and 

check for debris

Compression force too 

low

Check torque and 

compressive force

Immediate 

complete 

pressure loss

Tube or fitting leaks

See remedy under 

Tube/Fitting Leaks 

above

Summary of Contents for Pellicon 3 Cassettes

Page 1: ...ale Holder Installation 4 Hydraulic Process Scale Holder Installation 5 Maintenance 7 Flushing and Cleaning 7 Flushing 8 Cleaning 8 Sanitization 9 Depyrogenation 10 Integrity Testing 10 Measurement of...

Page 2: ...TE Pellicon 3 88 cm2 and 0 11 m2 Cassettes must be installed in a Pellicon Cassette Holder Catalog Number XX42PMINI Holder Installation 1 Loosen the nuts on the tie rods of the holder and remove the n...

Page 3: ...wipe 4 Slide the manifold adapter plate onto the holder against the holder s manifold plate with the solid light grey side labeled Manifold Side towards the manifold and the wings resting on the tie...

Page 4: ...ary Tri Clover connection Pellicon Cassette hex nut washer stainless steel bushing handle PERMEATE RETENTATE FEED Pellicon10_2_06_2 eps Gasket Plate manifold adapter plate nut PERMEATE R E T E N T A T...

Page 5: ...wrench and 15 16 in deep hex socket turn each nut 1 8 turn in the sequence shown in Figure 4 When the wrench clicks this indicates that the set force has been reached DO NOT OVER TORQUE Evenness of to...

Page 6: ...d tight 4 Turn on the air supply to the Hydraulic Power Unit A minimum of 80 psig air pressure should be available Check the air pressure on the pressure gauge PI 1 on Hydraulic Power Unit front panel...

Page 7: ...ut replacement of nuts and washers should be considered after every ten installations to maintain high sealing force in the holder 7 When new nuts do not spin freely refurbish the threaded rods with a...

Page 8: ...se the tank drain valve V1 and the tank valve V2 2 Fill the tank with the flushing solution 3 Fully open the retentate valve V4 and permeate valve V5 if present and direct both the retentate and filtr...

Page 9: ...iofilms Biopolymer Proteins and Polyphenolic Membrane Cleaning Agent Concentration Temperature C pH Time min Ultracel NaOH 0 1 N 0 5 N 25 50 13 13 7 30 60 Biomax NaOH 0 1 N 0 5 N 25 50 13 13 7 30 60 N...

Page 10: ...c Acid 0 1M 30 50 1 30 NaOH 0 1N 25 50 13 30 Ultracel NaOH 0 1N 25 50 13 30 Use milder conditions if effectiveness of agent is still observed Better membrane life is expected with lower concentration...

Page 11: ...l the tank with filtered deionized water water for injection or reverse osmosis permeate The flush water must be extremely pure to avoid fouling the membranes or introducing other contaminants into th...

Page 12: ...0 40 0 734 75 2 24 1 023 46 4 8 1 551 102 2 39 0 748 73 4 23 1 047 44 6 7 1 598 100 4 38 0 762 71 6 22 1 072 42 8 6 1 648 98 6 37 0 777 69 8 21 1 098 41 0 5 1 699 Based on Water Fluidity Relative to...

Page 13: ...ess compression and ensures that the units will not leak externally NOTE The storage agent used must comply with applicable local regulations Recommended Storage Solutions for Pellicon 3 Cassette Filt...

Page 14: ...completely flushed Flush system and cassette System and cassette not completely cleaned Clean system and cassette Symptom Possible Cause Remedy High NWP Damage to membrane or cassette Integrity test...

Page 15: ...xed below fluid air interface Vortex in feed container Add baffle to break vortex or reduce mixing speed Retentate splashing Fix retentate line below fluid in feed air interface container Pump cavitat...

Page 16: ...atory matters to the best of our knowledge and ability but without obligation or liability Existing laws and regulations are to be observed in all cases by our customers This also applies in respect t...

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