26
B. Braun Space is offering two modes for TCI:
•
TCI by targeting the plasma concentration
In this mode the user selects the desired concentration of a drug in the blood
plasma and the PK model is used to calculate the infusion rates required to
achieve that concentration as quick as possible (unless there is no restriction
defined by the user).
•
TCI by targeting the effect-site concentration
In this mode the user selects the desired concentration of a drug at the site
of action and the PK model is used to calculate the infusion rates required to
achieve that concentration as quick as possible (unless there is no restriction
defined by the user). A certain overshoot of the concentration in the plasma
is resulting from this mode.
For effect-site targeting there is a link between pharmacokinetics and
pharmacodynamics necessary. As the effect-site compartment is considered to
have no volume and the rate constant k
1e
can be ignored the rate constant k
e0
is the parameter necessary to perform effect-site TCI. A pharmacokinetic model
modified in such way is schematically depicted by the illustration on the next
page.
Chapter 3
SPECIAL FUNCTIONS
