
14
14
14
14----3
3
3
3
Endogenous and Exogenous Substances
Endogenous and Exogenous Substances
Endogenous and Exogenous Substances
Endogenous and Exogenous Substances
YSI has tested hundreds of substances to determine whether they have any effect
on the sensor system used in the SPORT. YSI has also verified that the addition
of Triton X-100 to the SPORT instrument buffer does not significantly alter the
extent to which these materials interfere with the instrument.
The endogenous substances listed were all tested at levels far higher than can be
found in the body, and all were found to be noninterfering at the highest
naturally occurring levels. The column headed "Interfering Level" indicates the
concentration at which each substance might be expected to cause an error of 1
mmol/l in the lactate reading. Certain exogenous substances can interfere with
measurements, and nothing should be added to the specimens except those
anticoagulants and antiglycolytics recommended in Appendix B–Sample
Collection and Handling.
Recent information indicates that some of the exogenous substances listed are
now drugs that are abused, that is, ingested at levels much higher than the
usually recommended therapeutic doses. In patients with higher than therapeutic
levels, there is hazard of gross masking of lactate concentration by the
interfering substance. The SPORT should not be used to analyze specimens
containing any of these substances at or above the listed Interfering Level.
Physical Damage
Physical Damage
Physical Damage
Physical Damage
Never inject concentrated mineral acids, concentrated bases, or strong organic
solvents into the YSI SPORT as these may permanently damage the enzyme
membranes or the plastic parts of the probe and sample chamber. Do not inject
water-insoluble oils or greases, because it may be difficult to clear them from
the sample chamber. Blood specimens with excessive content of fats are not a
problem.
Substance
Weight
Lactate Interfering Level
mg/dL
mmol/L
Anticoagulants:
Sodium Oxalate
134.00
-- --
Heparin Sodium
--
-- --
Dipotassium EDTA
404.46
-- --
Sodium Citrate
294.10
-- --
Preservatives:
Sodium Flouride
42.00
-- --
Iodoacetic Acid
185.96
24,346
1309
2-Iodoacetamide 185.95
3,356
180
Sodium Tetraborate 10 H2O
381.37
54,000
1416
Benzalkonium Chloride
396.11
1,200
30
Cetylpyridinium Chloride
357.99
-- --
Sodium Azide
65.01
588
90
Methylparaben 152.15
168
11
Phenol 94.11
6.7
0.71
Thymol 150.22
600
40
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