Thermo Scientific HyPerforma DynaDrive 500 L Скачать руководство пользователя страница 9

For Research or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.

 

© 2020 Thermo Fisher Scientific Inc. All rights reserved.  All trademarks are the property of Thermo Fisher Scientific and its 
subsidiaries unless otherwise specified.  

DOC0171 Revision A  1220

Find out more at 

thermofisher.com/dynadrive

Note:

 Attaching the top tabs will help keep the BPC 

properly oriented inside the tank. Figure 32 shows the 
top front BPC tab attached to the tab holder.

Figure 33. Inserting the RTD.

Figure 34. RTD in a probe clip.

•  Place a probe clip on the probe support hanger and 

place the RTD so it is resting in the hook (Figure 34).

Figure 35. Foam probe in holder.

29. Clamp the black foam probe holder to the outer 

support container, behind the top left tab holder, if 
facing the front of the S.U.B. Insert the foam probe into 
the foam probe holder on the outer support container 
(Figure 35).  

Figure 31. Placing black top tab 
holders on the top front of tank.

Figure 32. Black top tab holder 
with BPC tab attached.

24.  Gently pull at the bottom corners of the BPC until the 

sides of the BPC are straight. 

Note:

 You may need 

to wait for the BPC to fill with more air before this is 
possible. 

25.  While the BPC continues filling with air, remove all 

bubble wrap and polybags from the line sets.

26.  Remove the polybag from the drain line set, position 

the line clamp as close as possible to the BPC port, 
and then close the clamp. Use a cable tie around the 
clamp to ensure it does not open.

27.  Remove the plastic insert located in the thermowell, if 

present.

28. Insert the resistance temperature detector (RTD) into 

the thermowell (Figure 33) using the steps below. 

Note:

 

Due to the shorter thermowell on DynaDrive BPCs, the 
15.24 cm (6 in.) RTD is the ONLY compatible size. 

DO 

NOT

 use larger RTDs, which will damage the BPC.

•  Place a small amount of glycerol (0.5 mL) in the 

thermowell to aid in heat transfer. The glycerol also 
serves as a lubricant and aids in insertion.

•  The sensor should be inserted until the base of the 

RTD meets the mouth of the thermowell.

•  Secure by twisting the luer lock collar, if provided.

CAUTION:

 

•  The foam probe must be placed into the foam 

probe holder to prevent the foam sensor inside the 
BPC from becoming entangled with the drive train.

•  The 500 L foam probe holder must be removed 

prior to raising or lowering the motor lift to avoid 
damaging the BPC.

30. Optional: Connect a pressure sensor to the CPC 

aseptic connector at the top of the BPC. Then connect 
the appropriate pressure transducer cable to the third-
party controller.

Содержание HyPerforma DynaDrive 500 L

Страница 1: ...d not be moved by pulling of any kind The Thermo Scientific HyPerforma DynaDrive S U B may not be installed in a potentially explosive atmosphere as set forth in the applicable EU ATEX Directive It is the responsibility of the end user to review and understand the potential dangers listed in the ATEX 2014 34 EU guidelines Static electricity may build up in BPCs BioProcess Containers BPCs may act a...

Страница 2: ...erated under traditional eukaryotic cell culture conditions A general understanding of bioreactor systems and their operation is important prior to using the system for the first time Read and understand this user s guide before operating failure to do so could result in injury and potential loss of product Only trained operators should be allowed to operate the equipment For complete warnings saf...

Страница 3: ... ring if it is present Remove the tri clamp 2 Loosen the lockout nut using an adjustable or 1 25 in wrench not supplied until the nut is tight against the base or leg of the S U B Repeat this process for each load cell until all of the lockout nuts are disengaged from the lockout posts Do not reinstall the tri clamp 3 At this point the DynaDrive S U B hardware is ready to be prepared for BPC loadi...

Страница 4: ... jacket Figure 4 The inlet is typically on the right side if you are facing the connectors refer to the permanent labels on the inlet and outlet lines Figure 4 Attaching water jacket port using a tri clamp Note Refer to the TCU manufacturer s guidelines for detailed TCU setup information 10 Use the tri clamp fitting to attach the water jacket inlet outlet ports to the bottom of the outer support c...

Страница 5: ...se a safety cutter to carefully open the outer polybag Figure 10 Take care to not damage the BPC Figure 12 Pushing button on hub cover Figure 13 Hub cover opened Figure 14 Raising BPC lift lever Figure 6 Slitting open taped sides of the BPC box Figure 7 BPC secured to cardboard insert in box Figure 8 Carefully lifting out the BPC Figure 9 Folding up flaps on the insert 5 While another operator hol...

Страница 6: ...ngaged by attempting to push the lever back up If the hub is not locked the hub will fall out and the arm will raise 12 Locate the bottom hub at the bottom center of the BPC Pull the hub toward the center cutout at the bottom front of the outer support container Once the hub is aligned with the correct cutout slide it toward the back of the DynaDrive S U B until you feel it shift into place Figure...

Страница 7: ...the front linesets to keep them from tangling use the motor lift controller see the user s guide DOC0090 for information on using the motor lift controller to raise the pneumatic motor lift Figures 23 and 24 After raising the motor lift to its highest position turn the lock dial on the motor lift controller Note The controller cannot be locked unless the motor lift has been fully raised Figure 23 ...

Страница 8: ...ot rated as a pressure vessel DO NOT EXCEED 34 mbar 0 5 psi within the BPC or the system could fail causing personal injury or damage to equipment DO NOT leave the BPC unattended while inflating Consult your sales representative for recommended air flow rates The operating pressures at the level of the DynaDrive S U B are of primary importance and these values must be adhered to 22 Check the BPC t...

Страница 9: ...e air before this is possible 25 While the BPC continues filling with air remove all bubble wrap and polybags from the line sets 26 Remove the polybag from the drain line set position the line clamp as close as possible to the BPC port and then close the clamp Use a cable tie around the clamp to ensure it does not open 27 Remove the plastic insert located in the thermowell if present 28 Insert the...

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