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Material Safety Data Sheet
TITLE: MSDS, HFC REFRIGERANT BLEND TEMPTRONIC CORPORATION an inTEST COMPANY
Sharon, MA 02067
SHT 8 of 10 File: 17037BA A17037 Rev. A
8
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Section 11 – Toxicological Information
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CAS. NO 690-39-1
HFC-236fa:
Animal Data:
Inhalation 4hr LC50: >457,000 ppm in rats
Single exposure by inhalation caused narcosis and cardiac sensitization, a potentially fatal disturbance
of the heart rhythm associated with a heightened sensitivity to the action of epinephrine: in a cardiac
sensitization screening test in dogs exposed to concentrations of 50,000 to 250,000 ppm evidence of
sensitization occurred at 150,000 ppm. Repeated exposures caused a reduced startling response in rats.
No other significant toxicological effects were observed. No-Observed-Adverse- Effects- Level (NOAEL):
20,000 ppm.
Developmental studies conducted in rats and rabbits at dose levels of 5000, 20,000 or 50,000 ppm
produced no evidence of developmental toxicity. HFC 236fa was not uniquely toxic to the rat or rabbit
conceptus. Specific studies to evaluate the effect on female reproductive performance have not been
conducted; however, limited information obtained from studies on developmental toxicity do not indicate
adverse effects on female reproductive performance. Tests have shown that HFC-236fa does not cause
genetic damage in bacterial or mammalian cell cultures. No animal data are available to define carcinogenic
effects of HFC-236fa.
CAS. No. 75-46-7 HFC-23
Animal
Data:
Inhalation 4 hr LC50: >663,000 ppm in rats
HFC-23 is untested for skin and eye irritancy, and for animal sensitization.
No animal tests are available to define the carcinogenic hazards of HFC-23. The maternal and
developmental NOAEL was 50,000 ppm. It is not considered a unique developmental hazard to the
conceptus. There were no developmental or reproductive effects.
Tests have shown that HFC-23 does not produce genetic damage in bacterial or mammalian cell cultures. It
has not produced genetic damage in tests on animals.
Cas. No. 75-73-0
Halocarbon – 14
Animal
Data:
Inhalation 15 Minutes ALC: 895,000 ppm in rats
Effects observed in animals from exposure by inhalation to concentrations of >89%, v/v include central
nervous depression and death. Exposure by inhalation at concentrations as high as 22.4% resulted in no
observed adverse effects. No animal test reports are available to define carcinogenic, mutagenic,
embryotoxic, or reproductive hazards.