Waters ACQUITY UPLC I-Class, System Manual, Page: 21 / 68

System modules 1-9
Column manager (optional)
The ACQUITY UPLC I-Class column manager (CM-A) is an option for helping
to ensure precise, reproducible separations. The column manager can regulate
the temperature of columns from 4 °C to 90 °C. Its troughs can accommodate
columns of up to 4.6-mm I.D. and up to 150-mm length, depending on the
configuration. Each of the two column troughs can hold one column, up to
150 mm in length (with filter or guard column). The column manager also
offers a bypass channel and automated, programmable switching between
columns, for methods development. The column manager is installed with
two, column switching valves.
Restriction:
Derating: The minimum achievable column compartment
temperature set point must not be greater than 25 °C below the ambient
temperature.
Tip:
The column manager can be used for column switching and
two-dimensional chromatography applications. For information about two
dimensional applications consult the ACQUITY UPLC Systems with 2D
Technology Capabilities Guide .
Sample organizer (optional)
Requirement:
Verify that the sample organizer you use with your I-Class
system is compatible with sample managers fitted with a rotary tray.
The sample organizer stores multiple microtiter or vial plates and transfers
them to and from the sample manager, automating processing and increasing
throughput.
The sample organizer’s storage shelf compartment can hold a selection of
ANSI plates, which you load into the organizer through a large, swing-open
front door. A heater/cooler thermally conditions the shelf compartment and,
together with the sample manager’s heater/cooler, maintains the temperature
at a set point determined by the user.
Column technology
ACQUITY UPLC columns are packed with 1.7- μ m, bridged, ethylsiloxane,
hybrid or 1.8-
μ
m high-strength silica particles that can mechanically endure
high-pressure conditions. The column hardware can withstand as much as
124,106 kPa (1241 bar, 18,000 psi). The column dimensions allow optimal
MS-compatible flow rates, and matched outlet tubing minimizes the effect of
extra-column volume. Although the system works with most analytical HPLC