Izon qNano, User Manual, Page: 11 / 56

THE FUNDAMENTALS OF TRPS
What is TRPS?
Tunable Resistive Pulse Sensing (TRPS) enables the characterisation of
nanoparticles suspended in electrolytes. TRPS is the only technology that
can deliver:
— The concentration of particles in the fluid as number of particles per unit
volume of fluid, across a specified detectable particle size range.
— An accurate size distribution of these particles ideally plotted as a
histogram of concentration vs. particle diameter (or volume).
— The effective surface charge of individual nanoparticles (up to 800 nm in
PBS or KCl based electrolytes).
How does TRPS work?
TRPS technology uses the Coulter particle counting principle on the nanoscale.
1 /
Figure 1. A schematic representation of how TRPS works within the Izon system.
UPPER
FLUID CELL
LOWER
FLUID CELL
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