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JOHNSON CONTROLS
161
APPENDIX - MATERIAL SAFETY DATA SHEETS
FORM 161.01-OM1
ISSUE DATE: 6/8/2018
CEFSHP62
Du Pont
Material Safety Data Sheet
Page 7
Printed on 03/09/2011
mammalian cell cultures or when tested in animals (not
tested for heritable genetic damage).
HFC-134a
Inhalation 4-hour LC50: 567,000 ppm in rats
Single exposure caused: Cardiac sensitization, a potentially
fatal disturbance of heart rhythm associated with a
heightened sensitivity to the action of epinephrine.
Lowest-Observed-Adverse-Effect-Level for cardiac
sensitization: 75,000 ppm. Single exposure caused: Lethargy.
Narcosis. Increased respiratory rates. These effects were
temporary. Single exposure to near lethal doses caused:
Pulmonary edema. Repeated exposure caused: Increased
adrenals, liver, spleen weight. Decreased uterine, prostate
weight. Repeated dosing of higher concentrations caused:
the following temporary effects - Tremors. Incoordination.
CARCINOGENIC, DEVELOPMENTAL, REPRODUCTIVE,MUTAGENIC EFFECTS:
In a two-year inhalation study, HFC-134a, at a concentration
of 50,000 ppm, produced an increase in late-occurring benign
testicular tumors, testicular hyperplasia and testicular
weight. The no-effect-level for this study was 10,000 ppm.
Animal data show slight fetotoxicity but only at exposure
levels producing other toxic effects in the adult animal.
Reproductive data on male mice show: No change in
reproductive performance. Tests have shown that this
material does not cause genetic damage in bacterial or
mammalian cell cultures, or in animals. In animal testing,
this material has not caused permanent genetic damage in
reproductive cells of mammals (has not produced heritable
genetic damage).
HFC-143a
Inhalation 4-hour LC50: >540,000 ppm in rats
Single exposures by inhalation to 500,000 ppm caused
anesthesia but no mortality at 540,000 ppm. Cardiac
sensitization occurred in dogs at 300,000 ppm following an
intravenous challenge with epinephrine. Two, 4-week
inhalation have been conducted. In the first study,
pathological changes in the testes were observed at all
exposure concentrations; no effects were observed in
females. The testicular effect was considered related to
the method used to expose the rats to HFC-143a. In the
second study using the same exposure concentrations, no
effects were noted in males at any concentration. Data from
a 90-day study revealed no effects in male or female rats at
exposures up to 40,000 ppm. Long-term exposure caused
Print Date: 3 - 10 - 2011
Содержание YZ MODEL A
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