3.10.3 Cleaning the ion guide assembly
Required tools and materials
• Chemical-resistant, powder-free gloves
• Suitable vessel in which to completely immerse the ion guide assembly when cleaning
• Two lengths of PEEK, PTFE, or stainless steel tubing, appropriately sized for suspending the
ion guide assembly in the glass vessels when cleaning
• HPLC-grade deionized water
• Waters MS Cleaning Solution (186006846) or HPLC-grade (or better) 1:1 methanol/water
• Holding container for used Waters MS Cleaning Solution
• HPLC-grade isopropyl alcohol
• Ultrasonic bath
• Source of oil-free, inert gas (for example, nitrogen) for drying
Warning:
To avoid injury when working with MS cleaning solution, take care when handling it
and use a fume hood and suitable protective equipment.
Warning:
To avoid personal contamination with biologically hazardous or toxic compounds,
wear clean, chemical-resistant, powder-free gloves when performing this procedure.
To clean the ion guide assembly:
1. Bend a PEEK, PTFE, or stainless steel tube into a hook shape and use it to carefully
suspend the first ion guide PCB assembly in the glass vessel so that the bottom of the
assembly does not touch the bottom of the vessel.
Notice:
To avoid damage to the ion guide caused by vibration, ensure that the
bottom of the ion guide does not touch the bottom of the glass vessel.
August 20, 2021, 715005003 Ver. 04 (Previously released as Revision C)
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