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Tail-Flick Unit

General

This new style Tail Flick Unit has been designed to perform rapid precise screening of analgesic drugs via heat stimulation on the rat tail,

according to D’Amour & Smith

, see bibliography. It basically consists of an I.R. source, whose radiant energy of adjustable intensity is

focused on the rat tail by an embodied parabolic mirror.

The rat is held by the operator on the instrument unobstructed upper panel (see picture) in such a way that its tail, placed over a flush
mounted window, receives the I.R. energy.

The operator starts the stimulus and the related solid state second counter. When the rat feels pain and

flicks

its tail, a sensor detects it,

stops the second counter and switches off the bulb. The

reaction time

of the animal is thus determinedand automatically recorded.

PAIN and INFLAMMATION

Dedicated Software

Cat. No. 37360

RAPID and PRECISE

SCREENING OF

ANALGESIC DRUGS

ON THE RAT TAIL

Main Features

Automatic detection of the animal
response

Data portable to USB pen-drive

stick or to PC (USB)

Comfortable, unobstructed working surface (no
protruding elements)

Excellent reproducibility thanks to optics lodged

in a rigid structure & electronically controlled I.R.
flux

Memory Key included

Ugo Basile: more than 10,000 citations

Содержание 37360

Страница 1: ...UGO BASILE S R L sales ugobasile com service ugobasile com www ugobasile com instruction manual Tail Flick Unit Cat No 37360...

Страница 2: ...OWED TO ENSURE SAFE OPERATION AND TO RETAIN THE INSTRUMENT IN SAFE CONDITIONS SERVICE AND ADJUSTMENTS SHOULD BE CARRIED OUT BY QUALIFIED PERSON NEL AUTHORIZED BY UGO BASILE ORGANIZATION ANY ADJUSTMENT...

Страница 3: ...energy The operator starts the stimulus and the related solid state second counter When the rat feels pain and flicks its tail a sensor detects it stops the second counter and switches off the bulb T...

Страница 4: ...010 323 1 USB CABLE CAVO USB OPTIONAL 37360 325 MOUSE HOLDER 25mm I D CONTENITORE TOPO DIAM 25mm 37360 330 MOUSE HOLDER 30mm I D CONTENITORE TOPO DIAM 30mm DATE Serial No IMBALLATO DA PACKED BY Univer...

Страница 5: ...MENT 6 4 5 BEFORE APPLYING POWER 6 4 5 1 FUSE HOLDER 6 4 5 2 MAIN SWITCH 6 4 5 3 MAINS CORD 7 4 6 CONNECTIONS 7 4 6 1 BACK PANEL 7 4 7 INSTALLATION OF CUB SOFTWARE 8 4 8 INTENDED USE 8 4 9 GENERAL SAF...

Страница 6: ...IT 16 7 MEMORY MANAGEMENT 17 7 1 MEMORY RESET 18 7 1 1 MEMORY FULL MESSAGE 19 7 2 SETTING TIME DATE 19 8 REPRODUCIBILITY OF THE TEST 20 9 CALIBRATION 20 9 1 RADIOMETER 20 9 2 CALIBRATION VIA THE 37300...

Страница 7: ...ING UGO BASILE TAIL FLICK UNIT 27 14 APPENDIX 1 FIGURE INDEX Figure 1 Front Panel and USB slot 2 Figure 2 Top Panel 5 Figure 3 Power Module 6 Figure 4 Back Panel 7 Figure 4 Back Panel 10 Figure 6 Acqu...

Страница 8: ...mfortable unobstructed working surface No stray radiation 1 1 Principle of Operation The rat is held by the operator on the instrument unobstructed upper panel see 1 figure 1 figure 2 and datasheet pi...

Страница 9: ...ncy to hold its tail at 45 degrees up and therefore away from the heat source See also 5 5 1Mouse Restrainer 2 1 The Command Display Module This module of original design is located on the instrument...

Страница 10: ...Contrast 2 1 2 Keyboard The keyboard consisting of 4 soft push button keys F1 F2 F3 and F4 sets the experi ment parameters see paragraph 2 1 3 for reference 2 1 3 Function Key Abbreviations CAL Calib...

Страница 11: ...tru ments and store them into individual files ready to be easily managed by most statistical analysis packages available on the market See also paragraph 4 7 Ask for details 3 1 Data Portability Data...

Страница 12: ...otes on the Instruction Manual The Tail Flick Instruction Manual included in the package on the USB pen drive is nec essary for the correct installation and operation of the instrument We recommend re...

Страница 13: ...t of any watery solution see para graph 5 6 1 4 5 Before Applying Power Consider the Power Module on the back panel of the Tail Flick which includes from left to right the inlet connector of the mains...

Страница 14: ...ule the back panel embodies a connection module see figure be low Figure 4 Back Panel The connection module encompasses from left to right USB this USB type B connector for linking the Tail Flick to t...

Страница 15: ...mpt to open or perform any service work DO NOT connect up human subjects 4 10 Additional Safety Consideration a Place your Tail Flick on a flat surface b Do not obstruct free and comfortable access to...

Страница 16: ...or servicing problems In case the captions MEMORY LOSS appears on the display please refer to paragraph 10 1 1 Battery Replacement 5 2 Display Contrast To modify the display contrast depress the F2 F...

Страница 17: ...fact flick its tail when the heating reaches the threshold of pain and not as a consequence of its struggling to slip out from the operator s hand Some researchers roll up a cloth around the rat leav...

Страница 18: ...quence sequence number see 5 7 1 experiment number see 5 7 2 animal gender see 5 7 3 From the main menu depress the F2 FNC key followed by the F1 OUT key Depress again the key F2 FTR the display shows...

Страница 19: ...rom 1 to 9 can now be selected via the F1 UP or F2 DWN key and confirmed via the F4 OK key IMPORTANT The experiment number is also used to label the data export file on the USB pen drive for example D...

Страница 20: ...he instrument The involved parameters are I R Intensity Cut Off Time Experiment Number Gender Sequence Number MiniPrinter 5 8 1 From the Memory Key to the Instrument With the memory key inserted in it...

Страница 21: ...rms the overwriting 5 8 4 From Memory Key to PC With the memory key inserted in its slot on the PC it is possible to import or export a configuration to from the memory key From the CUB software selec...

Страница 22: ...an also be printed out in real time via the optional 57145 Thermal MiniPrinter see paragraph 12 2 In case of operation in conjunction with the Mini Printer the operator has to select the da ta output...

Страница 23: ...A which lists the experimental datum proper in the fol lowing format 04 2 30 1 M 01 Y where 04 2 Reaction time 30 I R Intensity 1 Experiment number M Animal gender 01 Sequence number Y Test OK 6 4 Qui...

Страница 24: ...AGEMENT Each datum point no matter whether print ed or sent to the PC is saved in the memory which can store about 300 measures including the datum proper and the date time indication By depressing th...

Страница 25: ...serial on COM2 at 9600 baud rate F3 MSK to select the Memory Key inserted in its slot on the front panel To interrupt the print out response of the stored data depress the F4 ESC key for one second a...

Страница 26: ...eviously saved in the memory are to not to be cancelled the researcher may print and or send them to the memory key or PC as previ ously explained see paragraph 7 MEMORY MANAGEMENT There is also the p...

Страница 27: ...intensity is remarkably constant 1 9 CALIBRATION The calibration consists of the measure ment of the I R output power of the Tail Flick with an I R Radiometer1 which in turn has been calibrated with...

Страница 28: ...al nociceptive stimuli of exactly the same intensity and balance them if necessary C Know the I R energy 1 mW for the duration of 1s corresponds to 1 mJ in ab solute terms a useful datum to compare wi...

Страница 29: ...of the instrument ought to be carried out by Ugo Basile personnel or by qualified personnel authorized by UGO BASILE organization this section of the instruc tion manuals describes normal maintenance...

Страница 30: ...m capability of about 300 measures Memory Full Message Always use the same type of batteries for replacement our part number E US 063 1 see paragraph 12 ORDERING INFORMATION The batteries are located...

Страница 31: ...otrusion on the glass rim of the bulb reflector Position the fresh bulb into its pentagonal receptor and rotate it until the mentioned pro trusion mates the rectangular cut of the supporting winglet T...

Страница 32: ...epair please contact our logistics department to obtain a return authorization number RMA and shipping packing instruc tions We may not be held responsible for damages during transport due to poor pac...

Страница 33: ...luding the following 37370 302 Instruction Manual 52050 10 CUB Data Acquisition Software Package E WP 008 Mains Cable E FF 002 Set of 2 fuses 2A 6 3x32 52010 323 USB cable 12 1 Spare parts E HR 002 Sp...

Страница 34: ...k Unit T O Lilius et alia The Mineralocorticoid Receptor Antagonist Spironolactone Enhances Morphine Antinociception Eur J of Pain online view 2013 J W Little et alia Spinal Mitochondrial Derived Pero...

Страница 35: ...f the CB1 Receptor Bioor ganic Medicinal Chemistry Letters 21 506 509 2011 M Spetea et alia In vitro and in vivo Pharmacological Profile of the 5 benzyl Analogue of 14 methoxymetopon a Novel Opioid An...

Страница 36: ...ical problems which af fect temperature per se An objective way to quantify the intensity of the IR stimulus is to calibrate its power Power may be quickly and definitively be measured in mW per squar...

Страница 37: ..._ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _...

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Страница 40: ...manufactured in compliance with the following European Union Directives and relevant harmonized standards 2006 95 CE relating to electrical equipment designed for use within certain voltage limits 20...

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