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4.1 Introduction
The AgilePulse
™
system provides the capability of delivering
DNA vaccines to the dermis. The system is designed for easy
set-up and operation.
Specifications are presented in Appendices A and B, Tabs 7 and 8.
The AgilePulse
™
system is composed of three subsystems:
• Touchscreen controlled AgilePulse Waveform Generator
• Intradermal Array (ID) parallel, needle electrodes
• User Manual
Optional equipment available includes:
• Foot Pedal (47-0420)
4.2 The AgilePulse Waveform Generator
The Waveform Generator (Figure 4-1) is composed of a computer
and high voltage pulsing circuits. The computer runs mobile
Windows
®
and is operated by a touch screen. On the front panel
there is a power switch, a touch screen, an emergency stop
switch, an electrode connector and two USB ports. All User
inputs are entered via the touch screen. The system may be
operated by using an optional foot pedal. On the back panel
there is a line/mains power connector.
The high voltage pulsing circuits are controlled by a
microcontroller. The microcontroller accepts user inputs from
the touch screen and produces the pulse waveforms. A second
microcontroller is used as an independent audit of the waveforms
produced. If the audit function detects a deviation from the desired
pulse protocol, the system immediately terminates pulsing. The
system also digitizes the output of the pulse voltage and pulse
current monitors and calculates the skin resistance of the tissue
on each pulse. This is a significant quality control function that
indicates the vaccine is being delivered properly. After the vaccine
is delivered, a log of all parameters is saved in Internal Memory and
on a USB memory key, if one is inserted.
Figure 4-1: Waveform Generator
AgilePulse
™
System Components & Set-Up
4
