1
Introduction
Introduction
Biotage
®
Flash 75 and Biotage
®
Flash 150 are flash purification
systems based on prepacked cartridge technology that provide
users of traditional self-packed glass columns with three critical
operational benefits: speed, safety, and performance.
Speed
Unlike glass columns, which operate at low pressure and
have very poor flow distribution, Biotage flash cartridges are
optimized for high speed separations. Purifications that might
otherwise have used up half a working day can be run in 15 to
45 minutes. For a chemist running just a single reaction and
separation per day, the annual gain in productivity can be as
high as 15 additional weeks each year; time that could be used
to develop new compounds or processes. With the rising cost
of labor, the efficiencies afforded by this alone can exceed the
cost of the flash system and a year’s supply of cartridges.
Safety
Laboratory and process safety is a growing concern with
many companies carefully reviewing current procedures and
techniques to reduce the risk of chemical exposure, injury, and
consequently their liability. Biotage Flash systems eliminate the
concerns of using glassware under pressure by utilizing durable
polyethylene cartridges that are prepacked and completely
self-contained, eliminating user exposure to silica dust, HP-API,
or any contaminants left after a separation.
Figure 1. Biotage patented radial compression technology improves flash separation performance and increases separation speed.
Distribution plate (only Flash 75)
O-ring
10 µm porosity frit
Prepacked, disposable flash cartridge
Compression barrel
Radial compression inert gas supply
316 stainless steel head
External
pressure
applied
Media
Performance
In addition to speed and safety, Biotage flash cartridges improve
both the performance and the reproducibility of separations.
The use of Biotage patented radial compression technology (see
Figure 1) reduces interstitial spaces (void volume) within the
packed bed. The optimized bed density means that compounds
are collected in narrow bands, which results in higher separation
efficiency. Unlike glass columns, each Biotage flash cartridge
will perform in the same way, time after time.
Flash 75/150 systems include everything you need to separate
compounds in a fume hood with standard laboratory mounting
bars, clamps, and an inert gas such as nitrogen. A typical
Flash 75/150 system can be assembled in minutes and be ready
to run samples in less than an hour.
Содержание Flash 150
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