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Scireq flexivent User Manual Download Page 61

59

SCIREQ currently offers the negative pressure forced expiration extension for mice and rats
only. Clients should use an FX module 1 with the mouse extension and an FX4 for the rat
extension.

For details on the hardware set up and use of the hardware extension with the

flexiVent

, consult

the SCIREQ TechNote 036 and other documentation that accompanies the hardware.

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Summary of Contents for flexivent

Page 1: ...USER MANUAL INTEGRATED PLATFORM FOR PRECLINICAL PULMONARY RESEARCH...

Page 2: ......

Page 3: ...ion of measurement manoeuvres including the Forced Oscillation Technique FOT management and storage of acquired raw data data analysis model fitting visualization storage and export of results and mai...

Page 4: ......

Page 5: ...eroneb are registered trademarks of Aerogen Inc Galway Ireland The information contained in this manual is believed to be accurate at the time of print However SCIREQ Scientific Respiratory Equipment...

Page 6: ...tances being introduced into the system to protect the user s Disengage the motor lock before connecting a power source Do not attempt to open the base unit cover while the instrument is running there...

Page 7: ...o clean the refill or inspiratory valves Do not attempt to clean or dry the expiratory line while an FX adapter is in place in the module Also do not attempt to clean or dry the expiratory line while...

Page 8: ...s not liable for damage or injury resulting from misuse of this product LIST OF SYMBOLS The following table describes the electrical and safety symbols that may be displayed on the flexiVent FX The sa...

Page 9: ...nnels Synchronization port in Synchronization port out Power supply connection Intake Inspiratory line Exhaust Expiratory line Inappropriate for disposal in general waste Aluminum components please re...

Page 10: ...y of Operation 17 2 Set up Installation 25 2 1 Selecting a Location 25 2 2 Preparing for Installation 25 2 3 Placing the System 28 2 4 Connecting the Components 28 2 5 Opening the flexiVent protective...

Page 11: ...nsion MSX 60 5 Cleaning Decontamination and Maintenance 61 5 1 Cylinder 61 5 2 Cleaning flow pathways and Valves 62 5 3 FX Adapter and Y tubing 66 5 4 External Surfaces 66 5 5 Aeroneb Nebulizer 67 5 6...

Page 12: ...x...

Page 13: ...noeuvre are analyzed by the software which reports measurements of mechanics The computer control of the piston and precision with which data are collected generates accurate reproducible measurements...

Page 14: ...lexiWare refer to the flexiWare user manual FIGURE 1 1 UNITWISE PLATFORM The flexiWare UnitWise platform consists of a variety of different components that are optimized for their individual tasks and...

Page 15: ...e from the comfort of their office 1 2 2 INSTRUMENTS SYSTEMS In UnitWise terminology instruments are compact laboratory instrumentation devices that possess both an Ethernet connection and several por...

Page 16: ...r UNIT without further adapters amplifiers or pods so that any UNIT can fit into and be recognized by any instrument port see Figure 1 2 Every UNIT contains between one and four sensor elements or oth...

Page 17: ...temperature controlled water bath UNIT C in Figure 1 2 provides a further example of the platform s flexibility as it shows 3 analog input channels communicating measurements to the software while a...

Page 18: ...use following setup and installation 1 3 FLEXIVENT FX SYSTEM OVERVIEW The flexiVent FX is composed of two main parts the base unit and a module The base unit includes the following a computer control...

Page 19: ...e airway constriction and stiffness of the lungs through relationships between pressure volume and flow using mathematical models 1 4 2 FORCED OSCILLATION TECHNIQUE Measurement manoeuvres executed by...

Page 20: ...e perturbations are established in the flexiWare software For detailed information about perturbation properties refer to the flexiWare user manual TABLE 1 1 STANDARD FLEXIVENT PERTURBATIONS NAME DESC...

Page 21: ...ject s respiratory rate e g SnapShot 150 for mice breathing at 150 br min Primewave Broadband multi frequency forced oscillation waveforms typically denoted by duration e g Prime 8 lasts 8 seconds PV...

Page 22: ...flows precise flow measurement can be quite difficult Flow measurement difficulty is compounded by signal losses due to gas compression so use of flow measurements to calculate mechanics is technical...

Page 23: ...e of calculating respiratory mechanics but also to provide feedback so the piston s movement may be adjusted as needed e g it will move less to generate a given pressure following administration of a...

Page 24: ...est precision mechanics measurements The piston cylinder set size determines whether or not the system is appropriate for work with a given subject so the system can be easily adapted for a wide range...

Page 25: ...lied may be adjusted in the ventilation pattern dialogue in the software and may be easily adjusted 1 4 9 INTEGRATING OTHER ACCESSORIES The flexiVent FX is highly configurable and may be integrated wi...

Page 26: ...24...

Page 27: ...space near the data acquisition workstation The flexiVent needs to connect to at least one power outlet more may be necessary if your instrument includes certain hardware extensions Your workstation l...

Page 28: ...ls The system may also contain the following optional components Nebulizer setup which includes an Aeroneb controller an Aeroneb nebulizer an FX adapter with nebulizer mount and a rainout characteriza...

Page 29: ...27 FIGURE 2 1 THE FLEXIVENT FX 3 1 2 7 8 9 10 11 12 13 5 4 6...

Page 30: ...level it and prevent unwanted vibrations Once the flexiVent is in place you may disengage the motor lock To disengage the lock refer to Figure 2 2 remove the thumb screw A then rotate the motor lock...

Page 31: ...he cable to a server data acquisition workstation or network port The appropriate connection for the Ethernet cable varies with the complexity of your UnitWise system 2 4 3 TRANSDUCERS ACCESSORIES Con...

Page 32: ...EXHAUST The intake and exhaust connections are at the rear side of the module These connections exist in order to introduce an external gas source e g filtered air or air with specific gas concentrat...

Page 33: ...s anaesthesia machine has different sized tubing The T piece s single port will be attached to the intake valve tubing The anaesthetic gas mixture will then be flowing past the intake valve and not di...

Page 34: ...operator 2 4 5 SUBJECTS Before attaching a subject to the flexiVent proceed through the start up sequence described in section 1 Failure to initiate the start up sequence in advance of connecting the...

Page 35: ...locked in order to ensure protection from moving parts Unlocking the cover should only be necessary in order to replace the module or for maintenance purposes Please carefully read all relevant docume...

Page 36: ...ntains multiple modules they will ship in separate packages If you would like to work with a module that shipped separately you must assemble the alternate module remove the one that is attached to th...

Page 37: ...1 2 AND 3 5 Align the O ring and the piston cylinder assembly with the module per Figure 2 6 6 Insert screws to hold the piston cylinder in place This step requires a 7 64 hex allen wrench Screws sho...

Page 38: ...n cylinder assembly with the module per Figure 2 7 2 Rotate the piston cylinder clockwise until it is secure but do not over tighten as this may cause damage 2 6 2 REMOVING A MODULE FROM THE FX BASE U...

Page 39: ...RING SCREW 5 Lift module upwards Be sure to unscrew the piston before attempting to remove the module Handle the module carefully Take extra precautions to protect piston rod because minor bending cou...

Page 40: ...see Figure 2 9 6 Attach the piston rod to the motor arm per Figure 2 10 FIGURE 2 10 PISTON ROD CONNECTED TO THE MOTOR ARM RIGHT 2 7 CONFIGURING FLEXIWARE The flexiVent FX is operated by flexiWare soft...

Page 41: ...to the flexiWare user manual STEP BY STEP INSTRUCTIONS An existing connection between the flexiVent FX and flexiWare software is required to proceed through the following step by step guide If you ha...

Page 42: ...al Should you prefer to use a study that is customized to your research refer to the flexiWare user manual for guidance using the Study Definition Planning module of the software 5 Enter the operator...

Page 43: ...agement to define one or more subjects that will be used in the current experimentation session To define a subject assign it a unique identifier and define its weight as shown in Figure 3 2 Other fie...

Page 44: ...TO THE MEASUREMENT SITE 12 If you have selected a template that includes aerosol delivery e g a default template with AN in its name you will be prompted to prime the nebulizer The settings for this a...

Page 45: ...The square to the right of the bar will turn green when a pressure adequate for calibration is reached During Step 4 of the calibration enter the exact pressure value applied by the using manometer F...

Page 46: ...amount of pressure applied is equal to the level of fluid in the single column Please refer to the instructions provided with the SCIREQ manometer for further details If you have questions concerning...

Page 47: ...5 cmH2O Min value 80 0 cmH2O 5 cmH2O FIGURE 3 8 RESULTS OF CALIBRATING THE AIRWAY OPENING PRESSURE CHANNEL If your values are not within the expected range please see the note above regarding proper u...

Page 48: ...nula attached to the end of the Y tubing Use the exact cannula that will be used for the experimentation The Dynamic Tube Calibration Wizard provides detailed steps for this process In short there are...

Page 49: ...he flexiVent executes each perturbation again Do not reposition or remove the cannula until all perturbations are complete Calibration Results The tube calibration results contain important informatio...

Page 50: ...libration If you continue to get values that are not within acceptable range please contact SCIREQ Technical Support The importance of proper calibration cannot be overstated Any errors or inaccuracie...

Page 51: ...stop ventilation if you have been recording data streams stop recording Once ventilation is stopped understand that your subject is no longer receiving air Data from the present experimentation sessi...

Page 52: ...or modification of a physical property In the case of UNIT transducers the sensing elements are intended to monitor and record vital signs e g body temperature and other parameters e g pressure UNIT t...

Page 53: ...ed in the database If you wish you may use the flexiWare heart rate analyzer to calculate a heart rate from the EKG trace 4 1 3 BODY TEMPERATURE The UNIT transducer for monitoring body temperature is...

Page 54: ...stopcock to isolate the syringe from the circuit 5 Connect an arterial line to the other end of the circuit via the three way stopcock furthest from the black box of the transducer and then open it t...

Page 55: ...PD 25 Digital precision differential pressure transducer 2 5 kPa nominal 2 5 2 5 kPa 25 5 25 5 cmH2O UT DPD 50 Digital precision differential pressure transducer 5 0 kPa nominal 5 0 5 0 kPa 51 0 51 0...

Page 56: ...in out will occur and may accumulate in the FX adapter and or Y tubing The rain out must be removed frequently to prevent airflow obstruction as excessive rain out may compromise mechanical ventilatio...

Page 57: ...step 6 Place the nebulizer on the mount of the FX adapter and push down until it is flush with the adapter base to ensure it is securely fastened 7 Proceed through the next steps of the start up seque...

Page 58: ...o or more similar nebulizers to operate at approximately the same output rate For example If nebulizer A has a slightly higher output than nebulizer B when run at default duty cycle 50 you can adjust...

Page 59: ...CALIBRATION ACCESSORIES The importance of proper calibration cannot be overstated SCIREQ has a number of accessories used only during calibration steps that may be integrated into your system 4 3 1 PR...

Page 60: ...tance Rrs outcomes similar to a healthy subject while the other test load produces outcomes similar to a constricted lung 4 4 HARDWARE EXTENSION FOR NEGATIVE PRESSURE FORCED EXPIRATIONS NPFE The SCIRE...

Page 61: ...ce and rats only Clients should use an FX module 1 with the mouse extension and an FX4 for the rat extension For details on the hardware set up and use of the hardware extension with the flexiVent con...

Page 62: ...collection and allowing you to expediently carry out time sensitive studies for example when respiratory mechanics measurements must be obtained within a limited time after birth or an intervention S...

Page 63: ...nsure a long lifespan of this component The cylinder does not require lubrication and should not be lubricated in any way for any reason The cylinder must not be exposed to particulate matter or aeros...

Page 64: ...ry pathway in which the expiratory valve is housed is cleaned at the end of every experiment day Additional items required for the cleaning procedure include the following a module cleaning kit produc...

Page 65: ...lexiVent 4 Connect the quick connects from the cleaning kit to the expiratory port on the front of the module A and the air gas exhaust port on the back of the module B per Figure 5 1 FIGURE 5 1 QUICK...

Page 66: ...64 FIGURE 5 2 TUBING ATTACHMENT FOR CLEANING 6 Place the beaker at the end of the tubing connected to the air gas exhaust port per Figure 5 3 FIGURE 5 3 FULL CLEANING CONFIGURATION...

Page 67: ...bing attached to the front of the module A 9 Remove both quick connects 10 Replace the FX adapter 11 Attach a test load e g syringe to the Y tubing 12 Start default ventilation and let it run for appr...

Page 68: ...ets remain in the small middle pathway to the module as this can result in damage to the module when the adapter is subsequently used for an experimentation session The Y tubing that connects subjects...

Page 69: ...1 NEBULIZER UNIT INCLUDING FILLER CAP 1 Disconnect the control module and cable from the nebulizer unit 2 Remove the filler cap from the nebulizer unit 3 Clean parts with warm water and mild liquid d...

Page 70: ...eld serviceable With an inspiratory and expiratory cartridge the module was designed to minimize the downtime required for annual cleaning and maintenance by allowing users to simply replace a cartrid...

Page 71: ...oted in section 2 2 the base unit is initially shipped with a module attached This is a configuration appropriate for storage and transportation To proceed with packing the base unit with a module att...

Page 72: ...x and packed with the flexiVent as long as there is adequate padding between it and the flexiVent 5 7 2 PACKING A MODULE SEPARATELY If your instrument includes multiple modules or if a module must be...

Page 73: ...rod per Figure 5 4 This step requires a 7 64 hex allen wrench 4 Gently pull the cylinder back from the module 5 Locate the O ring that is seated between the cylinder and module Place the O ring and sc...

Page 74: ...ODULE 1 2 OR 3 WRAPPED 8 Secure the cylinder and the wrapped piston to the plastic with tape or rubber bands The piston should not move within the cylinder if this is done properly 9 Secure the wrappe...

Page 75: ...rotate the cylinder counter clockwise per Figure 5 8 4 Gently pull the cylinder back from the module 5 Locate the O ring that is seated between the cylinder and module Place the O ring into a contain...

Page 76: ...the flexiVent FX need to be replaced periodically To order replacements contact SCIREQ Customer Relations The following table includes a listing of frequently replaced products TABLE 5 1 LISTING OF RE...

Page 77: ...FX Modules 1 2 and 3 FV FXY 1L Y tubing kit for FX Module 1 Luer end qty 6 FV FXY 23L Y tubing kit for FX Modules 2 and 3 Luer end qty 6 FV FXY 456B Y tubing kit for FX Modules 4 and 5 barbed end qty...

Page 78: ...th 22 8 cm in Height 14 5 5 cm in Width FX Base Unit Module 41 16 cm in Weight FX Base Unit 6 6 14 5 kg lbs 3 FX Base Unit Power Supply 1 1 2 5 kg lbs 3 FX Modules 1 3 2 7 6 kg lbs 3 FX Modules 4 5 4...

Page 79: ...Subject size Modules FX1 FX5 8 5 100 g 1 Control modes Software controlled mechanical and pressure controlled ventilation Gas supply Room air or non flammable mixed gas I E ratio 1 10 2 3 2 1 6 Numbe...

Page 80: ...ndensing 90 Storage and transport temperature 20 70 C Altitude 2000 6560 m ft Electronics Power supply output voltage 24 V DC Power supply output current 9 2 A Power supply input range 110 240 V AC Po...

Page 81: ...orts Available UnitWise transducer power entry data I O Power Voltage 12 V Power Current 0 25 mA Data Voltage 5 V Data Current 0 032 mA Lemo DC Power I O 7 pin snap lock connectors compatible with UNI...

Page 82: ...the module in use so refer to Table A 2 for details 6 The I E ratio in the software is expressed as a percentage of the exhalation time that the inhalation time lasts e g the default 2 3 I E ratio is...

Page 83: ...3 8 30 150 1 8 1 8 barbed FX2 4 22 20 85 420 3 16 1 8 barbed FX3 12 4 60 240 1 230 3 16 1 8 barbed FX4 28 2 150 560 2 810 3 8 1 4 barbed FX5 51 7 260 1 000 5 100 3 8 1 4 barbed Note 1 Minimum and maxi...

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Page 85: ...29andwewilldirectyourcall Tocontactusbyfax pleasedial 514 286 1627 EMAIL Toreachusbyemail pleaseusethefollowingaddresses ForCustomerService info scireq com ForTechnicalSupport TechSupport scireq com I...

Page 86: ...ation is believed to be accurate and free of errors at the time of print However all product specifications and other information are subject to change without notice Some product features are project...

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