Pall Allegro Instructions For Use Manual Download Page 10 | Manualshive

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System Installation

1. Install Allegro single-use system into the mixer tote.

A. Holding the system securely as shown below (Figure 12) align the shaft on the single-

use system, with the tube support in the centre of the mixer tote and the inlet port
plate to the right hands side of the impeller cover.

Figure 12

Holding the system (top left) ready to place system impeller shaft into the tube support mechanism
(top right) on the mixer tote and showing the system installed with doors open (bottom)

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USD 2743

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Summary of Contents for Allegro

Page 1: ...Allegro 200 L Single Use Mixer USD 2743 Instructions For Use ...

Page 2: ...hes Check 7 Allegro Mixer Tote Single use System Pre Installation Checks 9 System Installation 10 Mixer Bag Inflation 15 Adding Fluid and Solids to the Single use Mixer System 17 Operating the Mixer 19 6 Drain Removal Instructions 21 7 Troubleshooting 23 8 Specification Tables 24 9 General Maintenance Recommendations 25 10 WEEE Compliance Reuse Recycling and Recovery 2002 96 EC 26 11 CE Declaratio...

Page 3: ...ipping container 2 Take care when removing the supplied mixer hardware from the shipping container 3 Locate or store the hardware in an appropriate indoor location The equipment is designed for operation in clean rooms and classified areas and as such should be maintained in a clean state and stored when not in use in an appropriate clean location free from adverse environmental conditions 4 Only ...

Page 4: ...ure 2 Allegro single use mixer biocontainer 4 USD 2743 Motor Gear Box Full Access Doors Support Arm Mixer Tote User Control Interface UCI Mixer Biocontainer Flush Outlet Port Valve 4 Pitch Blade Turbine Impeller Inlet Port Plate Impeller Cover Powder Port Gas Inlet Gas Return Fluid Inlet Powder Inlet ...

Page 5: ...Figure 3 Allegro mixer tote open ready to accept single use system Figure 4 Allegro mixer tote with mixer system installed 5 USD 2743 www pall com biopharm ...

Page 6: ...ir nitrogen line to the supply shown below SUPPLY on the UCI using suitably rated and sized pneumatic tubing gas supply as per specification table see section 8 as shown in Figure 6 below Figure 6 Connection of the gas supply to the UCI 4 Check that the doors are closed and the handle is in the vertical closed position see Figure 9 5 Power up the unit by turning the main supply switch to the ON po...

Page 7: ...he UCI is illuminated green If the SHAFT LED is not illuminated green at this stage refer to Troubleshooting section 7 Figure 8 Depressing the SHAFT micro switch to confirm it is working prior to system installation 4 Close the doors to the tote and rotate the handle clockwise fully so that it is in the secured closed position vertical as shown in Figure 9 below 7 USD 2743 www pall com biopharm Po...

Page 8: ...rm micro switch Figure 10 Figure 10 Depressing the support arm micro switch to confirm correct operation prior to system installation 7 Check that the appropriate LED labelled SUPPORT on the UCI is green Figure 10 If the SUPPORT LED is not illuminated green at this stage refer to Troubleshooting section 7 Assuming correct operation of all safety micro switches the system is now ready for installat...

Page 9: ...during operation Figure 11 Mixer tote with 3 baffles installed prior to single use system installation and installing the baffles Allegro single use system check 1 Carefully open the protective bags containing the single use system using appropriate tools such as a safety knife so as not to damage any part of the system and remove Allegro Mixer system from its packaging retaining any appropriate l...

Page 10: ... the single use system with the tube support in the centre of the mixer tote and the inlet port plate to the right hands side of the impeller cover Figure 12 Holding the system top left ready to place system impeller shaft into the tube support mechanism top right on the mixer tote and showing the system installed with doors open bottom 10 USD 2743 ...

Page 11: ...cating plate on the outlet port is in correct location 2 Check that the appropriate LED labelled SHAFT on the UCI is illuminated green as shown in Figure 14 below If the SHAFT LED is not illuminated green at this stage please refer to Troubleshooting Section 7 Figure 14 SHAFT interlock illuminated indicating correct location of shaft 11 USD 2743 www pall com biopharm Locating Plate ...

Page 12: ...nects to the OUT line on the UCI as shown in Figure 15 below Figure 15 Inflation IN and exhaust OUT lines connected to the UCI Note Depending on system design it may be necessary to cut the ends of the inflation and exhaust lines in order to allow fitment over the hose barbs on the UCI 4 Check that the tubing on the fluid inlet line see Figure 16 is securely clamped shut Figure 16 Check fluid inle...

Page 13: ...r to filling 6 Carefully lift up the overhanging front section of the mixer biocontainer and close the doors starting with the left hand side door first ensuring the system locating plate is located under the closed door Figure 19 Figure 19 Closing the doors ensuring the system locating plate remains under the doors 13 USD 2743 www pall com biopharm System Locating Plate ...

Page 14: ...g Table Section 7 Figure 20 Handle to closed vertical position Figure 21 Securing the doors and checking the door micro switch is energized 8 Check the inside of the mixer tote to ensure no parts of the single use system are snagged or trapped 9 Lock the doors with the supplied key and remove Figure 22 Note The key can only be removed from the handle when in the locked position Figure 22 Locking t...

Page 15: ...he tote and the biocontainer Note 2 The inflation process will take around 5 minutes The UCI will control the inflation pressure during this step If inflation stops at any point before full inflation is achieved please refer to the Troubleshooting table under section 7 3 When full inflation is achieved the system will maintain the pressure in the single use system between 4 10 mbar 4 Secure the su...

Page 16: ...bleshooting table under section 7 Figure 25 System inflated regulated to 4 10 mbar and support arm connected to the powder port energizing the SUPPORT micro switch interlock Note When the SHAFT DOOR and SUPPORT interlocks are energized the READY light illuminates indicating the system is ready to accept fluid and begin mixing Also the speed controller for the mixer will also be energized and will ...

Page 17: ...e single use mixer system and commence filling of the system to the desired volume between 50 200 L Fluid flowrate into the system should be up to a maximum flowrate of 20 L min Note during the fluid filling process the pressure in the mixer biocontainer will increase slightly to approximately 10 20 mbar Caution When adding bulk fluid monitor the pressure on the bag inflation gauge Figure 27 to ma...

Page 18: ...he bag inflation control valve to the OFF position B Using either a suitable powder transfer biocontainer with the desired mass of solid or via simply adding the measured amount via a funnel add the desired mass of solids to the fluid volume When the powder port is opened the pressure in the mixer biocontainer will drop to zero Figure 28 Figure 28 Bag inflation set to OFF for powder addition where...

Page 19: ...n of rotation are controlled by the panel on the UCI The mixer can be rotated in a counter clockwise direction to provide down flow pumping action to the fluid or in a clockwise direction to provide up flow pumping action on the fluid Note Maximum life continuous mixing is 3 days 72 hours Figure 29 Setting the impeller speed rpm for the mixer 19 USD 2743 www pall com biopharm STOP RUN AUTO FWD RUN...

Page 20: ... REV Clockwise Up flow To change from current direction 1 Press Either FWD or REV will flash for approx 4 seconds indicating the new direction 2 Press within 4 seconds This will activate rotation in the opposite direction R F M Having set the rpm and direction to start the mixer press RUN The mixer will ramp up to the desired speed STOP RUN AUTO FWD RUN REV M R F To stop mixing press STOP The mixe...

Page 21: ...ort Gas Mixer Support Blanket When to Use Comments Off Detached Off When dispensing a stable The mixer biocontainer will collapse during fully mixed dissolved the draining process solution Draining will take approximately 40 minutes to drain 200 L assuming solution is drained under gravity and not using a pump Pump assisted draining will be quicker Running Attached On When maintaining Mixer will n...

Page 22: ...emove inlet outlet tubing from other systems so the mixer biocontainer can be removed 5 Unlock and open the tote doors 6 Remove the mixer biocontainer A Pull out the shaft of the mixer biocontainer by placing hands directly under the system either side of the impeller and pulling straight up Note Sometimes in order to remove the impeller shaft from the drive adapter it may be necessary after long ...

Page 23: ...ted correctly to power supply Malfunction of the Check the cable connection to the micro switch micro switch Replace with spare item see section 9 or call Pall for warranty servicing The single use mixer Check that the single use mixer system has not become system may be snagged stuck or snagged during the inflation process causing the inflation process to stop due to regulated pressure setting be...

Page 24: ...Weight 120 Kg without fluid in system Footprint 1054 mm W x 748 mm D Height 1378 mm Materials of Construction Mixer Tote 304 SS Mixer Biocontainer Biocontainer film outlet flange inlet manifold and top hat Low Density Polyethylene LDPE Impeller Polysulfone PS Outlet port Polysulfone PS Shaft Stainless Steel SS Outlet O rings Silicone Motor 0 37 kW UCI Details LGRMXUCI200L230 RPM 50 200 24 USD 2743...

Page 25: ...00L120 RPM 50 200 9 General Maintenance Recommendations It is recommended that the Allegro 200 L single use mixer be serviced on an annual basis Pall Advanced Separation Systems PASS servicing group can provide this as a service Please contact your Pall representative for further details In general the following critical spares should be considered to be held in stock since failure of these items ...

Page 26: ...fore should not be disposed of as unsorted waste but instead treated separately The presence of these materials may if not disposed of properly have potential adverse effects on the environment and human health Within the European Union users are urged to recycle such products when being replaced with a newer version or when they have outlived their useful lives However as the legislation and faci...

Page 27: ...CE Declaration 27 USD 2743 www pall com biopharm ...

Page 28: ...ngapore South Africa Spain Sweden Switzerland Taiwan Thailand the United Kingdom the United States and Venezuela Distributors in all major industrial areas of the world The information provided in this literature was reviewed for accuracy at the time of publication Product data may be subject to change without notice For current information consult your local Pall distributor or contact Pall direc...

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