Chapter 1: Introduction
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Original instructions
Samples Containing Volatile Substances
In certain cases the solvent in a sample to be freeze dried may contain volatile
components such as acetonitrile, methanol, acetic acid, formic acid or pyridine.
In addition to these substances having an effect on the eutectic temperature, they
may increase the vapor pressure at the surface of the sample. Also, compared to
water, they will require the absorption of less heat for sublimation to occur.
Hence, samples that contain volatile substances will have a greater tendency to
melt, particularly when placed in flasks or exposed to room temperature. If a
sample containing a volatile substance tends to melt when placed on a freeze dry
system, dilution of the sample with more water will help keep the sample frozen.
For example, a 0.2M solution of acetic acid is much easier to freeze dry than a
0.5M solution.
About This Manual
This manual is designed to help you learn how to install, use, and maintain your
Stoppering Tray Dryer. Instructions for performing routine maintenance and
making minor modifications to your Stoppering Tray Dryer are also included.
Chapter 1: Introduction
provides a brief overview of the freeze dry process,
explains the organization of the manual, and defines the typographical
conventions used in the manual.
Chapter 2: Prerequisites
explains what you need to do to prepare your site before
you install your Stoppering Tray Dryer. Electrical requirements are discussed.
Chapter 3: Getting Started
contains the information you need to properly unpack,
inspect and install your Stoppering Tray Dryer.
Chapter 4: Using Your Stoppering Tray Dryer
discusses the basic operation of
your Stoppering Tray Dryer. Information on how to load samples and run the
Stoppering Tray Dryer is included.
Chapter 5: Maintaining Your Stoppering Tray Dryer
explains how to perform
routine maintenance on your Stoppering Tray Dryer.
Chapter 6: Using the RS-232 Receptacle
describes how to connect a computer
for monitoring the operation.
Chapter 7: Troubleshooting
contains information about problems you may
encounter while using your Stoppering Tray Dryer, including the probable causes
of the problems, and suggested corrective actions.
Chapter 8: Modifying Your Stoppering Tray Dryer Display
describes how to
calibrate the vacuum display and restore factory settings.
