Lysis
1
– Lysis Buffer
ChemoMetec A/S
Document no. 995-0078
Edition No. 1
Revision date: 10 December 2019
Page 3 of 4
SECTION 10: Stability and reactivity
10.1. Reactivity:
No available data.
10.2. Chemical stability:
Stable under the recommended storage conditions - see section 7.
10.3. Possibility of hazardous reactions:
None known.
10.4. Conditions to avoid:
Excessive heating.
10.5. Incompatible materials:
Nylon, galvanized steel and chloride. Contact with materials containing chlorine may produce toxic gases.
10.6. Hazardous decomposition products:
When heated to high temperatures (decomposition) toxic gasses are formed.
SECTION 11: Toxicological information
11.1. Information on toxicological effects:
Hazard class
Data
Test
Data source
Acute toxicity:
Inhalation
LC
50
(rat, aerosol) = 25.5 mg/m
3
(corrosion) (Orthophosphoric acid)
LC
50
(rat) = 0.09 mg/l, dust (Cetylpyridinium chloride)
No info
No info.
RTECS
RTECS
Dermal
No available/applicable data
-
-
Oral
LD
50
(rat) = 1250 mg/kg (Orthophosphoric acid)
LD
50
(rat) = 200 mg/kg (Cetylpyridinium chloride)
No info
No info
RTECS
Litt.
Corrosion/
irritation:
Severe corrosion, eye and skin (100 mg/24h), rabbit (Orthophosphoric acid)
Moderate eye irritation, 10 µl/24h, rabbit (Octylphenol ethoxylate)
Severe irritation, eye and skin, rodents (Cetylpyridinium chloride)
Draize
Draize
Several
IUCLID
RTECS
Litt.
Sensitization:
No skin sensitization, guinea pig (Cetylpyridinium chloride)
No info
Litt.
CMR:
No CMR effects. (Orthophosphoric acid)
No carcinogenicity nor mutagenicity (Cetylpyridinium chloride)
Miscellaneous
No info
Various, ECHA
Litt.
Information on likely routes of exposure: Inhalation, skin and ingestion.
Symptoms:
Inhalation:
Vapours may cause slight irritation to the airways.
Skin:
May cause slight irritation by prolonged contact with skin.
Eyes:
May cause eye irritation.
Ingestion:
May cause irritation of the gastrointestinal tract, nausea, vomiting and headache.
Chronic effects:
Long term or repeated skin contact may degrease and cause red, dry, cracked and thickened skin.
SECTION 12: Ecological information
12.1. Toxicity:
Cetylpyridinium chloride is very toxic to the aquatic environment.
Aquatic
Data
Test (Media)
Data source
Fish
LC
50
(Cyprinus carpio, 96h) = 0.011 mg/l (Cetylpyridinium chloride)
LC
50
(Lepomis macrochirus, 96h) = >3 mg/l (Orthophosphoric acid)
No Info (FW)
No Info (FW)
EPA Ecotox
ECHA
Daphnia
EC
50
(Daphnia magna, 48h) = >100 mg/l (Orthophosphoric acid)
OECD 202 (FW)
EPA Ecotox
Algae
EC
50
(Desmodesmus subs. 72h) = >100 mg/l (Orthophosphoric acid)
OECD 201
ECHA
12.2. Persistence and degradability:
Cetylpyridinium chloride: 25% degraded in 28 d. (OECD 301D) - Not readily degradable.
Orthophosphoric acid dissociates in water and is part of the natural cycle as fertilizer
12.3. Bioaccumulative potential:
Cetylpyridinium chloride: Log K
ow
= 1.71 – possible bioaccumulation.
12.4. Mobility in soil:
No available/applicable data
12.5. Results of PBT and vPvB assessment:
No ingredients are PBT/vPvB, according to the criteria in REACH Annex XIII.
12.6. Other adverse effects:
None known
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Summary of Contents for NucleoCounter NC-202
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