1000DF00741 Issue 5
6/52
Alaris™ PK Plus Syringe Pump
TCI Overview
Pharmacokinetic models in Alaris PK Plus Syringe Pump and their parameters
Drug: Diprivan
Model: Marsh (weight adjusted)
Age Limit: 16 years upwards
Unit of Plasma Concentration: µg/ml
Max. Plasma Concentration: 15 µg/ml
Vc = 0.228 x mass (litres x kg
-1
)
k
10
= 0.119 minutes
-1
k
12
= 0.112 minutes
-1
k
13
= 0.0419 minutes
-1
k
21
= 0.055 minutes
-1
k
31
= 0.0033 minutes
-1
k
eo
= 0.26 minutes
-1
Reference from the literature: Marsh et al.: Brit J Anaesth 1991, 67, 41-48
Drug : Remifentanil
Model: Minto
Age Limit: 12 years upwards
Unit of Plasma Concentration: ng/ml
Max. Plasma concentration: 20 ng/ml
Vc = 5.1 - 0.0201 x (age-40) + 0.072 x (lbm-55)
V2 = 9.82 - 0.0811 x (age-40) + 0.108 x (lbm-55)
V3 = 5.42
cl1 = 2.6 - 0.0162 x (age - 40) + 0.0191 x (lbm - 55)
cl2 = 2.05 - 0.0301 x (age - 40)
cl3 = 0.076 - 0.00113 x (age - 40)
k
10
= cl1 / Vc
k
12
= cl2 / Vc
k
13
= cl3 / Vc
k
21
= cl2 / V2
k
31
= cl3 / V3
k
eo
= 0.595 - 0.007 x (age - 40)
Reference from the literature : Minto et al.: Anesthesiology 1997, 86, 10 - 33
Drug : Sufentanil
Model: Gepts (not weight adjusted)
Age Limit: 12 years upwards
Unit of Plasma Concentration: ng/ml
Max. Plasma concentration: 2 ng/ml
Vc = 14.3 l
k
10
= 0.0645 minutes
-1
k
12
= 0.1086 minutes
-1
k
13
= 0.0229 minutes
-1
k
21
= 0.0245 minutes
-1
k
31
= 0.0013 minutes
-1
Reference from the literature : Gepts et al.: Anesthesiology 1995, 83, 1194-1204
Additional :
k
eo
calculated with time to peak effect 5.6 minutes (k
eo
= 0.17559 minutes
-1
) (reference: Shafer et al Anesthesiology. 1991 Jan;74(1):53-
63)
