Advantech MIC-3716, Manual

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Fig. 3-2: Single-ended input channel connection
Differential Channel Connections
The differential input channels operate with two signal wires for each
channel, and the voltage difference between both signal wires is
measured. On the MIC-3716, when all channels are configured to
differential input, up to 8 analog channels are available.
If one side of the signal source is connected to a local ground, the
signal source is ground-referenced. Therefore, the ground of the signal
source and the ground of the card will not be exactly of the same
voltage. The difference between the ground voltages forms a
common-mode voltage (V
cm
).