Verifying the system using System QC
4-11
Verifying the system using System QC
The System QC function uses pre-defined LC/MS methods to test the system
by injecting a diagnostic sample on-column. The sample helps identify any
problems with the configured system by providing these data:
•
Sensitivity (signal-to-noise ratio)
•
Response (peak area, peak height)
•
Chromatographic performance (peak width, retention time)
System QC can be activated in several ways:
•
Manually, from the ACQUITY UPLC Console.
•
Manually, as part of an ACQUITY UPLC Console Autotune sequence.
•
Automatically, based on a scheduled date and time.
The following example shows you how to perform a manual verification.
See also:
The MassLynx online Help for details of how to perform verification
manually, as part of an Autotune sequence or automatically based on a
scheduled date and time.
Multiple injections are processed using the OpenLynx Application-Manager.
Measurements are reported for each chosen parameter across the repeat
analyses. If results are within user-defined tolerances, the LC/MS system is
ready to use.
The System Ready results are logged via the ACQUITY UPLC Console but
can also appear in a printed report. The raw data and OpenLynx browser
report are also stored for records.
Requirement:
For System QC to work, OpenLynx must be installed with
MassLynx. OpenLynx is normally installed by default. If it has not been
installed, run the installation DVD, select Modify, and select OpenLynx when
prompted.
Before running System QC you need a suitable tune file, method file and inlet
file. You can use IntelliStart to create a tune file and develop a method for the
sample you want to use for System QC.
See also:
“Performing a sample tune” on page 4-7
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