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Labscale Tangential Flow Filtration System User Guide 

13

Pellicon XL 50 Device

The Pellicon XL device is not included with the Labscale TFF 

System. It must be purchased separately. The Pellicon XL device 

includes an Accessories Kit that is packed in the Pellicon XL box 

below the device. The parts in the accessory kit are not required 

for this system installation.

User Supplied Materials

You will need to supply the following items for system setup: 

suitable containers for retentate, permeate and waste collection, 

scissors, a Pellicon XL Device.

Содержание Labscale

Страница 1: ...Labscale Tangential Flow Filtration System User Guide...

Страница 2: ...illipore Corporation Millipore Corporation assumes no responsibility for any errors that may appear in this document This manual is believed to be complete and accurate at the time of publication In n...

Страница 3: ...bscale 500 mL Reservoir Setup 16 Labscale Stir Base Set Up 19 Labscale Pump Module Set Up 21 Install Cleaning Tubing 25 Install Cleaning Tubing 25 Clean System 26 Drain System 27 Flush System 29 Flush...

Страница 4: ...46 Labscale TFF System Maintenance 47 Labscale Stir Base Spare Parts 47 Labscale 500 mL Reservoir Spare Parts 47 Labscale Pump Module Spare Parts 49 Pump Check Valve Flushing 50 Diaphragm Pump Mainte...

Страница 5: ...ore performing maintenance on the system Failure to follow instructions could result in user injury or system damage Read and understand all maintenance instructions in this operating instruction manu...

Страница 6: ...pressure product loss damaged cassettes chemical spills and pump damage Carefully follow all operating instructions Prior to each use carefully inspect all hoses and tubing for kinks or restrictions...

Страница 7: ...nnected to electrical power and have fuses installed to operate The Labscale system must only be uesd with the Millipore wall transfomer provided and Millipore accessories Location Power Supply Refere...

Страница 8: ...in an overpack carton that contains three separate cartons One carton contains the Labscale 500 mL Reservoir one contains the Labscale Stir Base with the Labscale pump module installed one contains t...

Страница 9: ...te pressure gauge indicates the pressure of the fluid exiting the Pellicon XL device The upper manifold includes a retentate back pressure valve The fittings used are polypropylene and stainless steel...

Страница 10: ...Shut off Valve 10 Fittings 10 Fittings 10 Clamps 1 Syringe 1 Stir Bar 1 Millex Vent 1 Operating Manual 3 Rotating Lock Rings 6 feet 1 8 m of Silicone translucent tubing 1 8 in 3 mm ID 2 x 1 ft 0 3m of...

Страница 11: ...nob for the stirrer is located on the front of the stir base 1 Stir Bar 120 V 230V GB 230V 2 Thumbscrews 1 Operating Manual 1 Stir Bar 120 V 230V GB 230V 2 Thumbscrews 1 Operating Manual Figure 4 Labs...

Страница 12: ...with the Millipore Labscale Stir Base 4 clamps 4 fittings 1 Installation Instructions 3 feet of Silicone translucent tubing 1 8 3mm ID 1 x 1 ft 0 3m of Sta Pure peristaltic pump tubing 1 8 in 3 mm ID...

Страница 13: ...parately The Pellicon XL device includes an Accessories Kit that is packed in the Pellicon XL box below the device The parts in the accessory kit are not required for this system installation User Sup...

Страница 14: ...instructions COVER MILLEX VENT FILTER VENT PORT FEED PRESSURE GAUGE RETENTATE PRESSURE GAUGE RESERVOIR SHUT OFF VALVE TANK OUT PORT FEED IN PORT RET OUT PORT PERM 2 OUT PERM 1 OUT RET IN PORT RETENTA...

Страница 15: ...ale 500 mL Reservoir set up with Labscale TFF System MILLEX VENT FILTER FEED PRESSURE GAUGE RETENTATE PRESSURE GAUGE ERVOIR T OFF VALVE OUT PORT FEED IN PORT PERM 2 OUT PERM 1 OUT PERMEATE TUBING Figu...

Страница 16: ...nslucent Install Retentate Tubing 1 Cut silicone translucent tubing and install fittings as shown in figure 10 L 15 cm 6 inches Fittings 1 male 1 female MALE FEMALE L L Appropriate length to reach MAL...

Страница 17: ...bing 1 Cut silicone translucent tubing and install fittings as shown in figure 12 L 15 cm 6 inches Fittings 1 male 1 female MALE FEMALE L L Appropriate length to reach collection vessel Fittings 2 mal...

Страница 18: ...tlet port TANK OUT and insert the female luer end of the tank outlet valve over the TANK OUT port Turn the lock nut until snug TANK OUTLET VALVE TANK OUT PORT MILLEX VENT FILTER VENT PORT PERM 2 OUT P...

Страница 19: ...1 Turn stirrer and pump if equipped speed controls to the off position 2 Connect power cord to power cord receptacle located at the rear of the system base 3 Align detent on connector with receptacle...

Страница 20: ...lugs from the pump inlet and pump outlet ports 2 Turn on the pump speed control set to 2 and listen for pump motor 3 Turn off the pump speed control 4 Turn on the stirrer speed control listen for the...

Страница 21: ...the Labscale Stir Base WARNING Disconnect power connection before proceeding 1 Remove the blank panels from the system base as shown in figure 18 2 Install gasket and make wiring connections as shown...

Страница 22: ...ite FIELD not used ARM 6 Black ARM 5 Red Pump Control 5 Red 6 Black After prolonged storage the tubing may absorb a small volume of water As a result the tubing color may change from translucent to op...

Страница 23: ...n figure 21 Use only one Sta Pure white tubing for pump outlet The other Sta Pure white tubing is used for cleaning Install Pump Inlet and Outlet Tubing 1 Insert one female luer end of the silicone tr...

Страница 24: ...ORT FEED IN PORT TANK OUTLET VALVE Figure 22 Install pump inlet and outlet tubing INSTALLATION TIP To reduce pump pulsation increase tubing length 100mm 4 in of additional tubing will only increase fi...

Страница 25: ...Figure 23 Setup of cleaning tubing fittings and clamps Remove the plug from the Device Feed port FEED and insert one of the female luer ends of the cleaning tubing over the FEED port Turn the lock nu...

Страница 26: ...e Fittings 2 female RETENTATE BACK PRESSURE VALVE VENT PORT WASTE COLLECTION VESSEL TANK OUTLET VALVE CLEANING TUBE DEVICE RETENTATE PORT DEVICE FEED PORT Figure 25 System Cleaning steps 1 6 3 Remove...

Страница 27: ...ten connec tions if required 8 Set pump speed to 2 Recirculate for 15 30 minutes Turn pump off RETENTATE TUBING RETENTATE TUBING PUMP OUTLET TUBING COLLECTION Figure 26 Setup for system cleaning steps...

Страница 28: ...retentate port Reconnect pump outlet Sta Pure white tubing 4 Disconnect pump outlet Sta Pure white tubing from FEED IN port and place in collection vessel Open tank outlet valve turn pump speed up to...

Страница 29: ...Labscale Tangential Flow Filtration System User Guide 29 Flush System Repeat instructions for System Cleaning substituting purified water in place of cleaning solution...

Страница 30: ...h Press device firmLy onto reservoir ports Turn the lock nuts until snug PERMEATE TUBING RETENTATE TUBING RESERVOIR FEED PORT RESERVOIR PERM 1 PORT RESERVOIR PERM 2 PORT RESERVOIR RET PORT DEVICE FEED...

Страница 31: ...d water Remove plug from VENT port and open tank outlet valve PERMEATE TUBING RETENTATE TUBING RESERVOIR FEED PORT RESERVOIR PERM 1 PORT RESERVOIR PERM 2 PORT RESERVOIR RET PORT DEVICE FEED PORT DEVIC...

Страница 32: ...connec tions if required 7 Adjust retentate valve restriction by slowly turning retentate valve clockwise until the retentate pressure gage reads 0 69 Bar 10 psi 8 Adjust pump speed and retentate val...

Страница 33: ...anslucent from the tank outlet valve Close the retentate valve Integrity Test Procedure 1 Obtain air integrity test pressure and airflow specifications from the Certificate of Quality supplied with th...

Страница 34: ...valve The Pellicon XL device is integral if the measured airflow is lessthan or equal to the airflow specification on the Certificate of Quality Preconditioning 1 Place end of permeate tubing silicon...

Страница 35: ...translucent from the permeate outlet PERM 2 port Drain permeate tubing into the waste collection vessel 2 Reconnect the permeate tubing to the PERM 2 port Concentration 1 Remove reservoir cover and fi...

Страница 36: ...rning retentate valve clockwise until the retentate pressure gauge reads 0 69 Bar 10 psi 5 Adjust pump speed and retentate valve restriction to achieve desired feed retentate pressures recommend 2 07...

Страница 37: ...d now drain by gravity If additional drainage is required a syringe can be placed on the end of the retentate tube and fluid can be blown down Figure 35 Product Recovery Setup 3 Replace retentate tubi...

Страница 38: ...up Diafiltration Vacuum Install Diafiltration Tubing 1 Cut silicone translucent tubing and insert a male luer x 1 8 barb port in one end of the tubing as shown here MALE Place the other end of the dia...

Страница 39: ...ltration DIA RECIRC port Plug VENT port 3 Insure that the end of the tubing remains below the buffer level at all times As you remove permeate a vacuum is created in the reservoir which will siphon di...

Страница 40: ...acked with the device for the most current cleaning solution information Cleaning Agent Concen tration Catalog Nos with prefix PXB Biomax polyether sulphone Catalog Nos with prefix PXC PL regenerated...

Страница 41: ...VENT port and either leaving open or installing a Millex Filter 4 Open tank outlet valve 5 Turn pump on increase pump speed until feed pressure gauge reads 1 38 Bar 20 psi Note Check system connectio...

Страница 42: ...just retentate valve restriction by slowly turning retentate valve clockwise until the retentate pressure gage reads 0 69 Bar 10 psi Adjust pump speed and retentate valve restriction to achieve 2 07 B...

Страница 43: ...Device Repeat flushing procedure detailed in Flushing section page 31 See instructions enclosed with the Pellicon XL device for storage information Clean Base 1 Disconnect power 2 Exterior surfaces o...

Страница 44: ...eight 45 7 cm 18 inches Weight 5 9 kg 13 lb Maximum pump outlet pres sure 5 86 Bar 85 psig Maximum gauge pressure do not exceed gauge scale Maximum Pellicon XL Device operating pressure see instructio...

Страница 45: ...ne Reservoir cover gasket EPDM Luer fittings 316 stainless steel and polypropylene Tubing Platinum cured silicone translu cent and Sta Pure white tubing Diaphragm pump housing glass filled polypropyle...

Страница 46: ...in voltage limits 89 336 CEE relating to Electromagnetic compatibility EMC Standards to which conformity is declared applicable are the following EMC emissions EN61000 3 2 Harmonic currents EN61000 3...

Страница 47: ...XX42LSS13 Includes Labscale 500 mL Reservoir Labscale Stir Base with Labscale Pump Module installed Labscale TFF system components are also available separately Description Catalog Number Labscale 50...

Страница 48: ...230 Pump head 480 mL min 3 roller XX8000003 Labscale system 1 8 in tubing kit XX80LFL25 After prolonged storage the tubing may absorb a small volume of water As a result the tubing color may change fr...

Страница 49: ...P43 5 Transformer 230V Great Britain 1 XX42LSP44 6 Motor Stirrer 1 XX42LSP45 7 Pump Assembly Diaphragm 1 XX42LSP46 8 Speed Controller Stirrer 1 XX42LSP47 9 Speed Controller Pump 1 XX42LSP48 Labscale 5...

Страница 50: ...Lok Male x 10 32 St St l 10 XX42LSP27 10 10 1 10 2 Tubing Platinum cured Sta Pure Tubing XX80LFL25 6 ft 2 ft 11 11 1 11 2 11 3 11 4 11 5 11 6 Plastic Fitting Kit Fitting Female Fitting Male Luer Lok P...

Страница 51: ...e Pump Module Spare Parts Item Description Qty per Cat Catalog Number 1 Fitting Male Luer Lok x 10 32 St St l 10 XX42LSP27 2 Manifold Pump 1 XX42LSP80 3 3 1 3 2 3 3 Pump Rebuild Kit Contains XX42LSP81...

Страница 52: ...silicone translucent from the tank outlet valve 3 Disconnect the pump outlet tubing Sta Pure white from the reservoir FEED IN port and place the end in a waste collection vessel 4 Fill a syringe with...

Страница 53: ...mp from the pump manifold 3 Remove the 2 check valves and 4 gaskets from the check valve housing 4 Install new check valves and gaskets as shown below Diaphragm Replacement 1 Unscrew the diaphragm fro...

Страница 54: ...D 1 DIAPHRAG M 1 CHECK VALVES 2 G ASKETS 4 PUMP SCREW S 4 FLOW FLOW IMPORTANT Check Valve orientation is as shown Improper orientation of the check valves will damge the check valves and cause the pum...

Страница 55: ...Labscale Tangential Flow Filtration System User Guide 55 Electrical Schematic...

Страница 56: ...te voltage AC adapter plugged into receptacle on the rear of system enclosure Check fuse on the rear of the system enclosure Pump operates but the stirrer does not Have a qualified technician check th...

Страница 57: ...See check valve replacement proce dure in maintenance section Diaphragm Pump Maintenance of this manual Have a qualified technician check the function of the pump speed controller No Flow Pump operati...

Страница 58: ...mp inlet or pump outlet tubing par ticulates may be impairing the pump check valves from closing Ensure pump check valves are clean See check valve flushing procedure in maintenance section Pump check...

Страница 59: ...Labscale Tangential Flow Filtration System User Guide 59...

Страница 60: ...isit the tech service page on our web site at http www millipore com techservice Millipore Pellicon Biomax and Millex are registered trademarks of Millipore Corporation The M logo and Labscale are tra...

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