Idexx VetTest, Руководство оператора

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H–11
Chemistry Description and Guide
Creatinine/CREA
Creatinine is a degradation product of creatine in muscle metabolism. The daily
production of creatinine is fairly constant and not influenced markedly by age, diet,
exercise, or catabolism. Creatinine is eliminated from the body by glomerular filtration
and tubular secretion in the kidneys.
Principal reason for performing the test:
As an indicator of renal disease and/or an index of glomerular filtration rate.
Most common abnormality indicated by the test:
Renal disease
Special precautions in sample collection:
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Oxalate/fluoride, citrate, or EDTA should not be used as anticoagulants. Remove
plasma or serum promptly from the clot or cells.
Complementary tests:
Creatinine determinations should usually be performed in conjunction with
measurements of urea, inorganic phosphate, total protein, and albumin. PCV can be
helpful as an indicator of reduced erythropoietin production. Appropriate urine tests
should also be performed (e.g., specific gravity and protein concentration).
An increase in both urea and creatinine provides a more reliable index of renal disease
than an increase in only one of the parameters, especially if changes are small. It is
generally accepted that serum urea concentration increases before creatinine in renal
disease in humans. However, the precise relationship between these tests in different
animal species remains to be determined. Until this is resolved it may be prudent
to perform both urea and creatinine determinations where early renal disease is
suspected.