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IDEXX VetTest* Chemistry Analyzer Operator’s Manual
Alkaline phosphatase/ALKP
The enzyme alkaline phosphatase is found in many body tissues. Highest levels are
found in the kidney cortex, small intestinal mucosa, and osteoblasts. In many instances
the enzyme is present in the epithelial cells lining excretory ducts.
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Sensitivity of the test in the cat may be low. Therefore, a modest increase in this species
can be an indicator of disease.
Principal reason for performing the test:
As an indicator of hepatic disease involving the biliary system.
Most common abnormalities indicated by the test:
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Special precautions in sample collection:
EDTA and fluoride/oxalate should not be used as anticoagulants. Remove plasma
or serum promptly from the clot or cells. Hemolyzed specimens should not be used
because ALKP contamination from red cells will occur.
Complementary tests:
Alkaline phosphatase activity is usually determined in conjunction with other tests of
hepatic function and damage.
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