Table C–1: Items exposed to solvent (KAD)
Item
Material
Gas exhaust port
Aluminum
Gas tubes
FEP (fluorinated ethylene propylene)
Ion block
Stainless steel
Ion block support
PEEK (polyetheretherketone)
O-rings
Viton or PTFE (polytetrafluoroethylene)-encapsulated Viton
Solvent waste/leak management Fluorinated ethyline polymer (FEP) tubing
Source enclosure
Aluminum
Waste bottle
Polypropylene
Pumping Block gaskets
FEPM
Waste bottle push-in fittings
NBR (nitrile butadiene rubber), SST (stainless steel), PBT
(polybutylene terephthalate), and POM (polyoxymethylene)
C.3.2 Solvents used to prepare mobile phases
The table below lists solvents and reagents used commonly to prepare mobile phase and, in
some cases, act as sample diluents. They are not expected to adversely affect the performance
of the materials shown in the table "Items exposed to solvent (KAD)" in
.
Note:
The list of solvents and chemicals and their associated concentrations shown below
presents the levels that have been tested, assessed, or both, for chemical compatibility with the
materials of construction. It is not a recommendation for optimal electrospray sensitivity. Mobile-
phase component concentration affects electrospray efficiency and sensitivity. Keep modifier and
buffer concentrations to the lowest levels that maintain chromatographic resolution.
Notice:
For LC/MS operation, do not prepare mobile phases using normal-phase
solvents like hexane. Such solvents adversely affect the performance of the materials
named in the list of items exposed to solvents (see
), and
should not be used except at or below the concentrations specified. In the event the
solvents are used at reduced concentrations as additives to mobile phases or as
sample diluents, you must evaluate the consequent compatibility issues.
Table C–2: Solvents used to prepare mobile phases (KAD)
Solution
Concentration
Water
100%
Methanol
100%
Acetonitrile
100%
June 15, 2017, 715003956 Rev. F
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