Roche CoaguChek Vantus, User Manual

Page: 14 / 324

14
Test principle
The CoaguChek XS PT Test test strip
contains a lyophilized reagent (reagent
in dried form). The reactive components
of this reagent consist of thromboplastin
and a peptide substrate. When a sample is
applied, thromboplastin activates coagulation,
which leads to the formation of thrombin.
At the same time, the meter starts to
measure the time. The enzyme thrombin
cleaves the peptide substrate, generating an
electrochemical signal. Depending on the
time elapsed when it first appears, this signal
is then converted by means of an algorithm
into an INR result.
Introduction
CoaguChek Vantus User’s Manual, version 1.0