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REPLIGEN XCell ATF Series, User Manual

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REPLIGEN XCell ATF Series User Manual Download Page 9

 
XCell

TM

 ATF System with C410:V4B Controller   

 

 

 

 

 

 

 

User Guide 

 

 

 

5 

1.2

 

XCell™ ATF

 System Control Scope and Objectives 

The C410 v4 Controller provides the process control functionality of the stainless steel 

XCell™ ATF 

4 System, 

XCell™ ATF 

6 System, 

XCell™ ATF 10 System and the XCell™ ATF 6 

and 10 Single-

use devices.  The XCell™ ATF 

C410v4B controller is designed to: 

1.

 

Control ATF flow rates in both pressure and exhaust cycles

 

2.

 

Provide a user interface capability for 

XCell™ ATF

 System control and monitoring

 

3.

 

Set-up and select operational parameters

 

4.

 

Display real-time process data and Alarms for error conditions

 

5.

 

Provide “

B

atch control” and user hierarchy

 

6.

 

Have PLC software upgrades in the field by replacing memory modules

 

7.

 

Have 3 major enclosures, an Electronics Box (E-Box) a Pneumatics Box (P-Box) and a 
Power Box

 

8.

 

Allow the E-Box to operate an 

XCell™ ATF 

4, 

6 and 10 systems and XCell™ ATF Single

-use 

6 and 10 devices using custom software 

 

9.

 

Allow the P-Box hardware and process parameters to be specific to the size of the   
particular 

XCell™ ATF

 System being controlled.

 

Control principles are detailed in Section 6. 

 

2.0

 

Utility Requirements 

 

UTILITY

 

REQUIREMENT

 

ADDITIONAL CONSIDERATIONS

 

PRIMARY 

COMPRESSED AIR

 

Maximum 90 psig /  

6.1 bar 

Oil free, dry, filtered gas, i.e., medical 

grade air

 

SECONDARY 

PRESSURE

 

Typically: 35 psi / 2.4bar,

 

Regulated oil free, dry, filtered air

 

VACUUM SERVICE

 

Minimum -12.5 psig

 

Vacuum supplied by a Repligen or 

customer supplied local pump capable of 

maintaining ~-12.5 psig with nominal 

flow as follows: 

XCell™ ATF4 

- 40L/min 

XCell™ ATF6 –

 60L/min 

XCell™ ATF10 –

 200L/min 

Pump should be clean room compatible

 

EXHAUST

 

 

Untreated discharge or user specified

 

ELECTRICAL

 

100-240V AC, 50/60Hz

 

NA

 

ENVIRONMENT:

 

Temperature: 0-50

°

C 

Relative Humidity: 0 

–

 80 

% RH

 

 NA 

STEAM (SIP)

 

~30lbs/hr.

 

Applicable only to a steamable 

connection between 

XCell™ ATF

 and 

bioreactor vessel

 

CONDENSATE DRAIN

 

 

For SIP condensate drainage  

Summary of Contents for XCell ATF Series

Page 1: ...XCellTM ATF System With C410 V4B Controller USER GUIDE XCell ATF4 XCell ATF6 XCell ATF10 ...

Page 2: ...ntability and fitness for a particular purpose Repligen Corporation shall not be liable for errors contained herein or for incidental or consequential damages in connection with the furnishing performance or use of this material No part of this document may be photocopied reproduced or translated to another language without the prior written consent of Repligen Corporation For further information ...

Page 3: ...s Box P Box Components 18 5 4 Electrical Box E Box 18 5 5 Power Box Power Separation Components 20 5 6 Primary Pneumatic Services 20 5 7 Primary Electric Services 21 5 8 Signal 21 6 0 C410v4B Controller Process and Control 22 6 1 Control Overview 22 6 2 Control Functional Algorithms 24 6 3 Interface and Screens 25 6 4 Startup 50 6 5 Examples 52 7 0 XCell ATF Hollow Fiber Module and Diaphragm Repla...

Page 4: ... and Quick Connects 62 Appendix 1 Cycle time vs Flow rate 63 Appendix 2 Access levels to the C410v4B controller 64 Appendix 3 Controller Lists Alarm Warning Inputs Outputs 71 Appendix 4 Profinet Communication 73 Appendix 5 Profibus Communication 75 Appendix 6 Delta V Example configuration 96 Appendix 7 OPC Communication 103 Appendix 8 Audit Trail If Equipped 113 Appendix 9 EU Declaration of Confor...

Page 5: ...t controller include a PLC Programmable Logic Controller with a HMI Human Machine Interface to control the components used in generating the alternating tangential flow action This User Guide pertains to both the Stainless Steel Filtration Assemblies and the XCell ATF Single use devices meaning that the C410v4B Controller information relates to the operation of both the stainless steel and single ...

Page 6: ...mp as shown in Figure 1 is used for controlled removal of a filtered stream The unfiltered material remains in the system Only a single connection is required between the XCell ATF System and the vessel As shown in Figure 1 the connection can be through a side port or bottom port commonly configured on large scale stainless steel or single use bioreactors or through the head plate as typical with ...

Page 7: ...o the pump flow control system Typically controlled addition of compressed air into the PA chamber increases the pressure in the chamber relative to the process vessel forcing the flexible diaphragm partitioning the two chambers to move into the PL chamber and towards the vessel Liquid in the PL chamber is forced through the filter to the process vessel The flow through the HFM lumen side generate...

Page 8: ...ssel that that is operated under positive pressure the vessel pressure can be used to drive the liquid from the vessel to the PL chamber When vessel pressure is limited it may be supplemented with vacuum In either of the above schemes one is driving the liquid from the vessel to the Diaphragm Pump by increasing the pressure in the vessel relative to the Diaphragm Pump Even with positive vessel pre...

Page 9: ...TF 4 6 and 10 systems and XCell ATF Single use 6 and 10 devices using custom software 9 Allow the P Box hardware and process parameters to be specific to the size of the particular XCell ATF System being controlled Control principles are detailed in Section 6 2 0 Utility Requirements UTILITY REQUIREMENT ADDITIONAL CONSIDERATIONS PRIMARY COMPRESSED AIR Maximum 90 psig 6 1 bar Oil free dry filtered ...

Page 10: ...d to accessories can affect height and effective area XCell ATF 4MC System 44 10 8x12 XCell ATF 6 System 44 10 8x12 XCell ATF 10lgcy System 44 14 14x20 XCell ATF 10 System 44 14 14x20 XCell ATF 6 Single use Device 38 12 10 XCell ATF 10 Single use Device 38 18 16 C410v4B Controller WEIGHT Kg COMMENTS PNEUMATIC BOX 13 ELECTRIC BOX Controls 23 POWER BOX 12 Power Separation Filtration Assembly XCell A...

Page 11: ...wn in Figure 3 Certain parts may vary depending on requirements and specifications Optional components for the XCell ATF housing include bioreactor connection kits pressure transducers vacuum pump and options for sanitary diaphragm valves All are available upon request Figure 4a Exploded View of XCell ATF 10 System Filtration Assembly P N ATF10 PH GMP ...

Page 12: ...cone 1 8 0 295 C S x 6 835 ID x 7 425 OD O Ring 50A Hardness Clear Silicone 2 9 90 Degree Elbow 1 5TC 316 SS 1 10 Sanitary Gasket 1 1 2 TC EPDM 5 11 Clamp Sanitary 1 1 2 TC 304 SS 5 12 Sanitary Gasket 3 4 TC EPDM 4 13 Sanitary Gasket 1 2 TC EPDM 3 14 Clamp Sanitary 1 2 3 4 TC 304 SS 7 15 Sanitary Cap 3 4 316 SS 2 16 Sanitary Diaphragm Valve 1 2 w TC ends 316 SS 3 17 Window Sanitary 1 5 TC AISI Typ...

Page 13: ...XCellTM ATF System with C410 V4B Controller User Guide 9 Figure 4b Exploded View of XCell ATF 10 Single use Device with 0 2u PES Hollow Fiber Filter ...

Page 14: ... ReadyMate to 1 TC Polycarbonate 3 12 Sanitary Gasket Silicone Silicone 3 13 XCell ATF 10 Branding Label Vinyl Decal 1 14 8 TC BioClamp Glass Filled Nylon GF Nylon 2 15 U Adapter 1 5 Sanitary Fittings PVDF 1 16 Aseptiquik x Insert 1 5 sanitary Polycarbonate 2 17 Adapter 1 MNPT x 1 Hosebarb PVDF 1 18 Sanitary Fitting Adapter 1 YC x 1 Hosebarb PP 1 19 Steridyne 0 2um Filter Capsule 1 x 3 4 TC Flange...

Page 15: ...XCellTM ATF System with C410 V4B Controller User Guide 11 Figure 4c Exploded View of XCell ATF 6 System Filtration Assembly P N ATF6 PH GMP ...

Page 16: ... Hollow Fiber Cartridge PC PS w Hollow Fibers 1 13 Silicone Size 337 70A O Ring Silicone 2 14 Sanitary Gasket TC EPDM 2 15 Pressure Gauge TC 30 PSI to 30 Hg ASI Type 316L stainless steel 1 16 Reducer ATF6 SA 479 316L SS 1 17 Sanitary Gasket 1 TC EPDM 1 18 Elbow 90 Deg 1 0 TC Ends 316 SS 1 19 Sanitary Cap AISI Type 316L stainless steel 1 20 Sanitary Gasket 1 TC EPDM 2 21 Clamp Sanitary 1 TC 304 SS ...

Page 17: ...XCellTM ATF System with C410 V4B Controller User Guide 13 Figure 4d Exploded View of XCell ATF 6 Single use Device with 0 2u PES Hollow Fiber Filter ...

Page 18: ...l suATF6 Polycarbonate 2 10 Sanitary Gasket 3 4 TC Silicone 1 11 413 O Ring Class VI 70A Silicone Silicone 2 12 233 O Ring Class VI 70A Silicone Silicone 2 13 Air Inlet Filter w 1 4 NPT male ends gamma stable PVDF 1 14 Poly Tube 1 4 ID x 3 8 OD White Polyurethane 18 in 15 GE ReadyMate to 1 TC Polycarbonate 3 16 GE ReadyMate to 3 4 TC Polycarbonate 1 17 1 TC 90 Deg Elbow PVDF 1 18 1 TC BioClamp Gla...

Page 19: ...XCellTM ATF System with C410 V4B Controller User Guide 15 Figure 4e Exploded View of XCell ATF 4 System Filtration Assembly P N XCell ATF4 PH GMP ...

Page 20: ... Type 316L stainless steel 1 10 Sanitary Gasket 2 TC EPDM 2 11 Hollow Fiber Module PC PS w Hollow Fibers 1 12 Filter Housing Assembly ATF 4 AISI Type 316L stainless steel 1 13 GMP O Ring ATF4 Silicone 2 14 Reducer ATF4 SA479 326L SS 1 15 Clamp Sanitary 3 TC AISI Type 316L stainless steel 2 16 Silicone Tubing W TC Ends ATF2 Silicone 1 17 Clamp Sanitary 3 4 TC AISI 304 SS 5 18 Sanitary Gasket TC EPD...

Page 21: ... 5a the primary design objective is to produce a modular system that will maximize adaptability of the system to the various space requirements of the user s facilities One can envision the P Box in proximity to the Filtration Assembly while the E Box positioned distant to the Filtration Assembly possibly mounted on a wall or a skid A stainless steel cart specifically designed to house the three c...

Page 22: ... 0 to 4 1 bar k Vacuum gauge 0 to 14psi 0 to 0 95 bar l System STOP Switch m Plugs for sensor inputs 4x4 20mA n Interconnect Cable Plug pneumatics o Connection for Diaphragm Pump p Pressure regulator 0 to 60psi 0 to 4 1 bar q Connection for compressed air r Connection for vacuum supply Figure 5b Pneumatic Box Connections 5 4 Electrical Box E Box The E Box contains the HMI and PLC components includ...

Page 23: ...atics c Interconnected Cable Plug power d Illuminated system stop button e n a Illuminated On OFF switch relocated to power box component u in C410v4B f HMI OIT Display g n a not available for C410v4B controller h Harvest Pump Relay Outputs 2 i Alarm Relay Outputs 2 j Ethernet connection port k Profibus connection port Figure 5c Electric Box E Box Connections ...

Page 24: ... Do not exceed 90 psi 6 1 bar on the Air inlet Exhaust vacuum line r Located on the P Box Leaving the Exhaust outlet open to the atmosphere or connected to a vacuum line will depend on the type of process vessel used For a vessel that cannot be pressurized e g some stainless steel vessels glass vessels SUB etc the line is connected to a vacuum source For a vessel that is pressure rated one may use...

Page 25: ...the P Box Typical range of gauge is 0 60psi It shows second stage system pressure Vacuum Gauge k Located on the upper side of the P Box Typical range of gauge is 0 to 14psi 0 95 bar It shows primary vacuum pressure status 5 7 Primary Electric Services Electric plug t Located on the power separation portion of E Box Electric power standard 100 240V AC 60 50Hz Power switch u Located on power separat...

Page 26: ... is fully inflated the pressure within the pump chamber will begin to spike e g the diaphragm stops moving and begins to stretch The controller takes advantage of this spike by using a cycle Switch Offset SO to indicate when to switch to the Exhaust cycle Similar mechanism applies to the Exhaust cycle To assure optimum results with the XCell ATF System one should keep in mind the following two gen...

Page 27: ...TF 10 System 6 0L See also Appendix 1 Cycle time vs Flow rate Therefore selection of a Flow Rate L min by a user using an XCell ATF System with a known Pump Displacement Volume L it is possible for the C410v4B controller to calculate the Pump s Cycle Time Calculated CT At the end of each pump cycle the Actual Cycle Time Actual CT is compared to the Calculated CT The controller then uses the error ...

Page 28: ...pressure with the PRV Adjustments in flow are based on the error difference between Calculated CT and Actual CT The proportional air pressure regulating valve PRV1 and the exhaust pressure regulating valve PRV2 will be adjusted by the PLC based on the Error The error will cause pressures to be changed to affect the flow positive or negative respectively to and from the pump to match flow set point...

Page 29: ...ill appear on screen to enable data input For numerical entries as the value is being typed a Min and Max range dialog box appears showing the user the acceptable value range Any value outside the min max range or any text strings or letters is not accepted The OIT will display the following Primary Screens Primary Screens INITIAL MAIN SET UP ALARMS TRENDING BATCH ADMINISTRATOR LOG OFF Secondary S...

Page 30: ...410v4B controller is powered up Press the Logon button to bring up the User Password Dialog Box and Keyboard For first time use enter ADMIN for USER and 1234 for PASSWORD Many of the main screen parameters are actively displayed as read only on this screen for user convenience Logging on is not required to observe remote control operations ...

Page 31: ...ting the Diaphragm Pump a dialog box will appear to enable the user to start with current settings start with default settings or cancel and return to the main screen b When stopping the Diaphragm Pump a dialog box will appear that enables the user to confirm the stop command or to cancel and return to the main screen 3 Access other screens based upon password security levels 4 Observe P2 trending...

Page 32: ...low Calculated cycle time Sec E FLOW Actual When running displays Actual pump exhaust cycle Time of last pump cycle Sec PV1 Displays current position Set Point of Flow Proportional Valve 0 100 PV2 Displays current position Set Point of Exhaust Proportional Valve 0 100 PRV1 Displays current setting of automatic pressure regulator 0 to 35psi PRV2 Displays current setting of automatic exhaust regulat...

Page 33: ...ox will appear Yes setting is preferred when stopping the Diaphragm Pump and restarting with the same flow rate or process settings i e same PRV and PV values as when the Diaphragm Pump last ran Default setting is preferred when starting the Diaphragm Pump with new flow rate settings or new process setup e g different bioreactor configuration parameters This minimizes the number of cycles taken by...

Page 34: ...n password security levels The Basic Set Up screen will display the parameters in the following tables Field Description Controller Set Up Groups the following fields Pump Model No Press to select Pump Model No XCell ATF 4 4MC 6 10lgcy 10 These settings apply to both stainless steel and single use systems Control Mode Press to select Control Set Point units FLOW or TIME Alarm Delay min The amount ...

Page 35: ...Pressure cycle Pressure Offset or Over pressure Set Point P OSP1 value psi above P2 to switch from Flow or Pressure cycle to Exhaust E Pressure Offset psi Exhaust cycle negative Over pressure Set Point E OSP2 value psi below P2 to switch from Exhaust cycle to Flow or Pressure cycle P Delay Sampling point of sP2 during the Pressure cycle of total cycle time preset range 10 to 90 E Delay Sampling po...

Page 36: ...XCellTM ATF System with C410 V4B Controller User Guide 32 From the Advanced Set Up Engineer Administrator can set the following Diaphragm Pump Parameters C 2 ADVANCED SET UP ...

Page 37: ...int LPM Min E FLOW sec Minimum limit for Exhaust FLOW set point Seconds PV1 Max Maximum operating limit for PV1 PV1 Min Minimum operating limit for PV1 PV2 Max Maximum operating limit for PV2 PV2 Min Minimum operating limit for PV2 PRV1 Max psi Maximum operating limit for PRV1 psi PRV1 Min psi Minimum operating limit for PRV1 psi PRV2 Max psi Maximum operating limit for PRV2 psi PRV2 Min psi Minim...

Page 38: ...he C410v4B controller The Start Up Guide screen does not display parameters Navigation buttons are described in the following table Button Description Basic Set Up Press to switch to Basic Set Up Screen Advanced Set Up Press to switch to Advanced Set Up Screen Calibration 1 Equipment Calibration All Primary All Primary Screen Buttons are displayed to navigate to those screens C 3 START UP GUIDE ...

Page 39: ...llowing tables Field Description Entries on Screen Field entries 14 Eng Units PV1 PRV1 PV2 PRV2 Eng Units 14 places Enter the Minimum Engineering Value for the selected analog input to the left of 1st Point and the Maximum Value to the left of 2nd point Actual Value Displays input value after the two point calibration is performed PV1 Displays current position Set Point of Flow Proportional Valve ...

Page 40: ...2 Min Check box While checked the following is set 1 The solenoid is set to the vacuum position 2 PV2 is commanded to 100 3 PRV2 is commanded max vacuum The readout of the P2 sensor is displayed to the right Accept This button provides the measured P2 value to the controller also displayed on the advanced Set Up screen as the minimum PRV2 setting Pressing this accept button also unchecks the above...

Page 41: ...User Guide 37 The Trending screen displays an Overview screen from where the following trends are selected This screen monitors in real time the Flow and Exhaust Set Points and Process Values in Liters per Minute LPM D TRENDING D 1 PROCESS TREND ...

Page 42: ...imum value for the chart Y Axis Button Description Scrolls back to the beginning of the trend recording The start values with which the trend recording started are displayed Zooms into the displayed time section Zooms out of the displayed time section Scrolls back one display width Scrolls forward one display width Starts or continues trend recording Stops trend recording Primary Screens All Prima...

Page 43: ...s Min Enter minimum value for the chart Y Axis Button Description Scrolls back to the beginning of the trend recording The start values with which the trend recording started are displayed Zooms into the displayed time section Zooms out of the displayed time section Scrolls back one display width Scrolls forward one display width Starts or continues trend recording Stops trend recording Primary Sc...

Page 44: ...tly proportional to the position of the diaphragm within the Diaphragm Pump which drives how much liquid is in the Diaphragm Pump This provides useful real time information on the position of the diaphragm within the Diaphragm Pump which is indicative of the cycle time and the effectiveness of the pressure and vacuum cycles That information may be used to i Monitor if the diaphragm cycles its full...

Page 45: ...matically stop the pump cycling action while a Warning condition allows the pumping cycling action to continue Warning and Alarm conditions are described in the following section The Alarm screen will display parameters in the following tables Field Description Time Indicates time of Alarm Date Indicates Date of Alarm Text Describes Alarm Button Description Horn Acknowledge Press to turn off Horn ...

Page 46: ...nly if Relay 1 is ON i e in Power On Running state C or Power On Warning state D The following is a list of C410v4B controller Warnings that can occur during normal operation Flow Set Point cannot be reached P Flow Regulator PV1 above maximum operating setting Flow Set Point cannot be reached P Flow Regulator PV1 below minimum operating setting Exhaust Set Point cannot be reached E Flow Regulator ...

Page 47: ...One 1 Administrator Level User Admin Several Engineer Level User Eng1 User22 User23 User24 User76 Several Operator Level User Oper1 User1 User10 User11 User21 Only administrators have security access to add edit delete all other User ID s by touching the appropriate fields Each User ID includes a field for Logoff Time in minutes When the time of inactivity is reached the current user will automati...

Page 48: ...ity level Log Off Time Set the amount of time in minutes before current user is automatically logged out A value of zero will disable this feature Button Description All Primary All Primary Screen Buttons are displayed to navigate to those screens Basic Navigates to ADMIN Basic Screens Each level of security allows different levels of access to the C410v4B controller control functionality please r...

Page 49: ... all batches since reset Profibus Node Address Defaulted to 2 This entry field allows for selecting alternate node addresses Pressure Engineering Units Either PSI as shown or Bar Display Date Time Either Display as shown or Hide Selecting Hide removes the Date Time display from all screens This was installed in the event that the system time had lost time synchronization with a central manufacturi...

Page 50: ...t Mode Either Remote as shown or Local This slider switch selects whether the system will start up in after power up in remote control or local HMI control Button Description Clean Screen Siemens Touch Panel HMI utility which temporarily deactivates the touch screen Intended to allow cleaning of the screen without activating any buttons Calibrate Touchscreen Siemens Touch Panel HMI utility fine tu...

Page 51: ...isplays user defined OPC input parameters addresses and values OPC Outputs Displays pop up screen of OPC output parameters addresses and values Input Page 0 4 Displays user defined Profibus inputs by page of parameters addresses values and feedback values Output Page 0 5 Displays Profibus outputs by page of parameters addresses and values Calibration Displays calibration settings in the PLC Users ...

Page 52: ...nt batch run Time is reset by changing Batch Name Cycle Count Displays Diaphragm Pump Cycle count of current batch run User ID Displays Users ID Engineer or Administrator Batch Set Up Set Batch Name and reset Cycle count Name Click on field to change batch name Button Description Cycle Count Reset Resets Cycle count to zero in Batch Data field Algorithm Navigates to Batch Algorithm Screens All Pri...

Page 53: ...ay parameters in the following tables Field Description Algorithm Performance Tracks cycle change mechanism Primary Method Shows cycle count triggered by Set point method tracks Pressure cycle and Exhaust cycle counts Overtime Shows cycle count triggered by Overtime tracks Pressure cycle and Exhaust cycle counts Overflow Shows cycle count triggered by Overflow tracks Pressure cycle and Exhaust cyc...

Page 54: ...tween pump midpoint and vessel liquid level is 0cm Regulated air pressure set to 35psi Vacuum source connected 6 4 1 Following LOGON and entry of BATCH Information go to the SET UP screen 6 4 2 Go to the BASIC SET UP screen and enter the following field values Field VALUE Controller Set UP Pump Model No Select XCell ATF 6 Control Mode Select FLOW Slope Function Enable Do not enable Bioreactor pres...

Page 55: ... changed to time 6 4 5 Press Accept Changes 6 4 6 Go to the MAIN screen enter Field VALUES P FLOW Status SP Lpm 12 E FLOW Status SP Lpm 12 6 4 7 Note that PV and PRV fields are populated 6 4 8 Check all XCell ATF System connections 6 4 9 Press START Once the system begins to cycle Note the following The deviation of Actual Flow from Set Flow The deviation between the two should be small Following ...

Page 56: ...iew of positioning the Filtration Assembly P Box and E Box relative to the bioreactor Example 1 Using an unpressurized bioreactor with an XCell ATF 6 System When using a bioreactor that cannot be pressurized such as a glass vessel or a disposable vessel i e SUB the connection between the Filtration Assembly and the SUB will most likely not be an SIP type connection shown in Figure 1 Placement of t...

Page 57: ... of XCell ATF System Note also the small up and down change in vessel liquid level indicating XCell ATF System cyclic flow Changing flow rate To change flow rates simply go to the main screen select P Flow SP Enter the new flow rate on the pup up menu Press Yes to accept current PV and PRV values or press Default to accept default PV and PRV values Default is recommended when entering new flow rat...

Page 58: ...ximity of the Filtration Assembly 7 1 7 Close and disconnect the filtrate line 7 1 8 Disconnect the Filtration Assembly from the vessel as follows a1 Securely close both bivalves connecting the Filtration Assembly to the vessel a2 Drain liquid from the connection Optionally purge the connection with water steam or some other medium a3 Disconnect the Filtration Assembly from vessel between the two ...

Page 59: ...attached O rings The O ring is placed in a recess at the housing ends between HFM and Reducer or Diaphragm Pump Clamping the connection between Reducer or Diaphragm Pump and the Filter Housing squeezes the O ring effectively forcing the O ring against the filter wall effectively sealing the three parts Figure 8 Types of Filter Housings 1 3 1 S Line HFM insertion b1 Lay the Filter Housing horizonta...

Page 60: ...ween the Housing Reducer and HFM c6 On the other end of the Filter Housing Place the second O ring into the formed groove between HFM and Housing end ferrule c7 Carefully place the Filter Housing onto the Diaphragm Pump forcing the O ring deeper into the groove c8 Clamp the Filter Housing to the Diaphragm Pump c9 Assemble the XCell ATF System 7 4 Screen Module replacement If the SM is being used c...

Page 61: ...he XCell ATF 10 System these two parts are assembled first The two Diaphragm Pump hemispheres are assembled with the diaphragm pointing into the PL pump hemisphere e2 Clamp the two hemispheres with the C clamps use the three long clamps first and place 120 degrees to each other about the Diaphragm Pump periphery e3 Uniformly and sequentially tighten the clamps so the diaphragm is compressed evenly...

Page 62: ...by autoclaving is one of the simplest methods to sterilize the system In addition to the procedure below please refer to the XCell ATF System Filter Preparation and Autoclave Guide for further details Pre Autoclaving check list 8 1 1 Thoroughly wet the HFM with appropriate wetting agent 8 1 2 Fully assemble Filtration Assembly as shown in Figure 9 8 1 3 Perform a pressure test 8 1 4 Vent all ports...

Page 63: ...cedure so not to damage attached parts or tubing Avoid kinking or stressing attached tubing 8 2 Autoclave Cycle 8 2 1 The Xcell ATF systems have been designed to be sterilized using an autoclave The XCell ATF System Filter Preparation and Autoclave Guide provides detailed guidance on the entire procedure including the recommended filter integrity test procedures and specifications The features of ...

Page 64: ...to evacuate all of the air within the assembly and ensure that there is a uniform temperature throughout the assembly prior to engaging the ramp up to reach the sterilization temperature Follow with a 1 minute steam purge to about 6psi and 108 C Ramp up slowly 1C min to sterilization temperature pressure of 121 C 123 C 16psi Sterilize for 55 60 min Ramp down slowly with wet cycle exhaust protocol ...

Page 65: ...le hose between the main branches of the two valves Steam inlet The side valve on one of the bivalves may be used for steam inlet Condensate The side valve on the other bivalve is used for drain condensate This valve should be the low point valve to assure complete condensate drainage Attach a steam trap to this valve and connect to a drain Close both Steam inlet and Condensate valves Securely con...

Page 66: ...r The replacement of the pump air inlet filter will be determined by how the system is configured If the air filter is autoclaved with the Filtration Assembly it is qualified for 135 C for 30 minutes 3 times 10 3 O Rings gaskets and Quick Connects The O rings on the ventilation ports and quick connects XCell ATF 4 System and XCell ATF 6 System should be replaced every two or three runs Replacement...

Page 67: ...tem PUMP VOLUME L XCell ATF 4 4MC 0 4 XCell ATF 6 1 3 XCell ATF 10 5 1 XCell ATF 10H 6 0 Cycle time sec FLOW RATE L MIN 4 6 0 18 8 76 5 90 0 6 4 0 12 5 51 0 60 0 8 3 0 9 4 38 3 45 0 10 2 4 7 5 30 6 36 0 12 2 0 6 3 25 5 30 0 14 1 7 5 4 21 9 25 7 16 1 5 4 7 19 1 22 5 18 1 3 4 2 17 0 20 0 20 1 2 3 8 15 3 18 0 ...

Page 68: ...iew only Sec Calculated View Only Sec Actual View Only E Flow Status LPM SP Not Allowed LPM PV View Only Sec Calculated View Only Sec Actual View Only P2 Trends Enable View Only change range in trends PV1 Input value Not Allowed PRV1 Input value Not Allowed PV2 Input value Not Allowed PRV2 Input value Not Allowed P2 General View only Bioreactor View Display only Batch View Display only Runtime Vie...

Page 69: ...ed No Access Bioreactor Pressure No Access Height Differential No Access Pump Parameters Pressure Offset No Access Delay Time No Access Over Time No Access PV Step Size No Access Alarm Set Points P2 Pressure No Access Alarm Delays No Access Set Up Advanced User Set Point Ranges Pressure Cycle Flow No Access Pressure Cycle Flow Max No Access Pressure Cycle Flow Min No Access Exhaust Cycle Flow Max ...

Page 70: ... PV2 Input value Allowed PRV2 Input value Allowed P2 General View only Bioreactor View Display only Batch View Display only Runtime View Display only Current User View Display only Alarms View Only General Allowed Silence Alarm General Allowed Clear Alarm General Not Allowed Trending Process Trend General View and allowed to adjust Min and Max P2 Trend General View and allowed to adjust Min and Ma...

Page 71: ... Size Allowed to Change Alarm Set Points P2 Pressure Allowed to Change Alarm Delays Allowed to Change Set Up Advanced User Set Point Ranges Pressure Cycle Flow Allowed to Change Pressure Cycle Flow Max Allowed to Change Pressure Cycle Flow Min Allowed to Change Exhaust Cycle Flow Max Allowed to Change Exhaust Cycle Flow Min Allowed to Change Output CV Limits PV1 Allowed to Change PV2 Allowed to Ch...

Page 72: ...d P2 General View only Bioreactor View Display only Batch View Display only Runtime View Display only Current User View Display only Alarms View Only General Allowed Silence Alarm General Allowed Clear Alarm General Allowed Trending Process Trend General View and allowed to adjust Min and Max P2 Trend General View and allowed to adjust Min and Max PRV Trend General View and allowed to adjust Min a...

Page 73: ...Up Advanced User Set Point Ranges Pressure Cycle Flow Allowed to Change Pressure Cycle Flow Max Allowed to Change Pressure Cycle Flow Min Allowed to Change Exhaust Cycle Flow Max Allowed to Change Exhaust Cycle Flow Min Allowed to Change Output CV Limits PV1 Allowed to Change PV2 Allowed to Change PRV1 psi Allowed to Change PRV2 psi Allowed to Change Accept Changes Allowed to Change Discard Change...

Page 74: ...Allowed Pressure Units Toggle PSI Bar Allowed when in local mode Logon Splash Toggle Allowed Profibus 1 Access Allowed Profibus 2 Access Allowed Profinet Access Allowed Admin Users General Access General Access Allowed User Password Maintenance User Allowed for all except Admin and PLC User Password Allowed for all except for PLC User Group Allowed for all but Unauthorized Logoff time Allowed ...

Page 75: ...DB1 WARN_REG 0 Flow Set Point cannot be reached P Flow Regulator PV1 above maximum operating setting Pump is Running PV1 PV1MAX N A Warning Activate System Fault Warning Horn DB1 WARN_REG 1 Flow Set Point cannot be reached P Flow Regulator PV1 below minimum operating setting Pump is Running PV1 PV1MIN N A Warning Activate System Fault Warning Horn DB1 WARN_REG 2 Exhaust Set Point cannot be reached...

Page 76: ... A N A N A N A CR2 Pump Controller Status Relay 2 Q0 4 N A N A N A N A N A CR3 Pump Interlock Relay 3 Q0 5 N A N A N A N A N A CR4 Pump Interlock Relay 4 Q0 6 N A N A N A N A N A PL2 System Stop Indicator Q0 7 N A N A N A N A N A Spare N A N A N A N A N A N A Spare N A N A N A N A N A N A Spare N A N A N A N A N A N A RAW_P2_PV_1 Pump Pressure IW96 Note 1 1 PSI N A Y 44 7 RAW_PRV1_PV_1 Inflation P...

Page 77: ...ndustrial Ethernet in providing real time channel for time critical communications i e process data Configuration The communications interface between the controller HMI and PLC is based on Profinet Industrial Ethernet The controller is factory set to the following IP settings IP Address Subnet Mask Default Gateway HMI 192 168 1 167 255 255 255 0 None PLC 192 168 1 168 255 255 255 0 None This fact...

Page 78: ...fields populate with the current configuration h From this interface the IP Address Subnet Mask and all other Ethernet Properties can be adjusted i Once the values have been entered select device download and IP to assign the address to the device IP suite settings could be assigned appears at the bottom of the window j Exit out of the assign IP 3 Set Connection between HMI and PLC k From the Serv...

Page 79: ... SendingDataPage from the Master a timer is started After 500ms the XCell ATF controller begins copying the values from the Profibus input to the parameters defined in Input Signals from Master to XCell ATF tables provided the system is in remote control mode and the selector switch is set to Profibus Should a parameter from the master be changed without changing page the value is copied immediate...

Page 80: ...can be requested at time of ordering a new system Prerequisites The XCell ATF should be calibrated and connected to a Bioreactor or other vessel The XCell ATF should be in a Remote Control Mode Remote Set up The master sends input parameters pages 1 and 2 to XCell ATF or set up the parameters locally The Start Stop parameter should be 0 Remote Start The master sends analog input parameters page 0 ...

Page 81: ...essure gauge and loop wiring is connected The following steps are performed 1 An enable bit is momentarily asserted Controller is enabled in calibration mode for a particular analog input 2 Pneumatic devices are set to produce a minimum setting The pressure in the system approaches the minimum value commanded Pressure gauge reading is allowed to stabilize 3 The pressure gauge reading is provided t...

Page 82: ...the OutputPage4 P2_P1_Caputured bit is received i Wait for the RequestedDataPage to be equal to 4 since cycling through output data pages is recommended ii Examine OutputPage4 P2_ P1_Capture When true e Reset InputPage3 P2_P1_Capture 0 the minimum capture bit is momentarily asserted 4 Pneumatic devices are set to produce a maximum setting PV1 100 PRV1 20 00 PSI Solenoid 1 pressure or air a While S...

Page 83: ...ngDataPage is still equal to 3 b Set InputPage3 P2_Accept 1 until the OutputPage4 P2_Accept bit is received i Wait for the RequestedDataPage to be equal to 4 since cycling through output data pages is recommended ii Examine OutputPage4 P2_Accept When true c Reset InputPage3 P2_Accept 0 d Controller performs the linear scaling calculation and resets the controller s internal calibration enable bit ...

Page 84: ...e0 ATF_Connected_Bioreactor DB31 DBW134 ATF Connected Bioreactor Int 16 6 7 InputPage0 SpareBytes1 0 Byte 8 SpareBytes1 1 Byte 9 SpareBytes1 2 Byte 10 SpareBytes1 3 Byte 11 SpareBytes1 4 Byte 12 SpareBytes1 5 Byte 13 SpareBytes1 6 Byte 14 InputPage0 PFLOWSP DB31 DBD144 Pressure Flow Setpoint LPM LPM Real 15 16 17 18 InputPage0 PTIMESP DB31 DBD148 Pressure Flow Setpoint Time SEC Real 19 20 21 22 In...

Page 85: ... Switching BAR PSI Real 16 17 18 19 InputPage1 Press_Cycle_Delay_Time_SP DB31 DBW208 Pressure Cycle Delay Time SP Int 16 20 21 InputPage1 Press_Cycle_Over_Time_SP DB31 DBW210 Pressure Cycle Over Time SP Int 16 22 23 InputPage1 Pres_Cycl_PV_Step_Size DB31 DBD212 Pressure Cycle PV Step Size Real 24 25 26 27 InputPage1 EDFOFST DB31 DBD216 Exhaust Driving Force Offset for switching BAR PSI Real 28 29 ...

Page 86: ...B31 DBD256 Max Pressure Flow Setpoint SEC Real 10 11 12 13 InputPage2 PTIMEMINSP DB31 DBD260 Min Pressure Flow Setpoint SEC Real 14 15 16 17 InputPage2 ETIMEMAXSP DB31 DBD264 Max Exhaust Flow Setpoint SEC Real 18 19 20 21 InputPage2 ETIMEMINSP DB31 DBD268 Min Exhaust Flow Setpoint SEC Real 22 23 24 25 InputPage2 PV1MAX DB31 DBD272 Flow Proportional Valve Max Value Real 26 27 28 29 InputPage2 PV1MI...

Page 87: ...Page3 P2_P1_EU DB31 DBD398 P2 First Point Cal Engineering Units PSI Bar Real 22 23 24 25 InputPage3 P2_P2_EU DB31 DBD402 P2 Second Point Cal Engineering Units PSI Bar Real 26 27 28 29 InputPage3 PRV1_P1_EU DB31 DBD406 PRV1 First Point Cal Engineering Units PSI Bar Real 30 31 32 33 InputPage3 PRV1_P2_EU DB31 DBD410 PRV1 Second Point Cal Engineering Units PSI Bar Real 34 35 36 37 InputPage3 PRV2_P1_...

Page 88: ...C410 V4B Controller User Guide 84 Input Page 3 Continued Profibus Address Tagname plc in DB31 PLC Address Definition Units Data type Byte Bit Structure Tagname in structure 54 4 Force_Solenoid DB31 DBD431 4 5 6 7 55 63 Unused ...

Page 89: ... Value PSI Bar Real 18 19 20 21 InputPage4 P4_P1_EU DB31 DBD454 P4 First Point Cal Engineering Units PSI Bar Real 22 23 24 25 InputPage4 P4_P2_EU DB31 DBD458 P4 Second Point Cal Engineering Units PSI Bar Real 26 27 28 29 InputPage4 P5_P1_EU DB31 DBD462 P5 First Point Cal Engineering Units PSI Bar Real 30 31 32 33 InputPage4 P5_P2_EU DB31 DBD466 P5 Second Point Cal Engineering Units PSI Bar Real 34...

Page 90: ... System with C410 V4B Controller User Guide 86 Input Page 4 Continued Profibus Address Tagname plc in DB31 PLC Address Definition Units Data type Byte Bit Structure Tagname in structure 50 51 52 53 54 55 63 Unused ...

Page 91: ...sure Cycle Time SEC Real 8 9 10 11 OutputPage0 EFLOW DB31 DBD322 ATF Exhaust Cycle Flow LPM Real 12 13 14 15 OutputPage0 ETIME DB31 DBD326 ATF Exhaust Cycle Time SEC Real 16 17 18 19 OutputPage0 PV1 DB31 DBD330 ATF Pressure Proportional Valve PV1 Position Real 20 21 22 23 OutputPage0 PV2 DB31 DBD334 ATF Exhaust Proportional Valve PV2 Position Real 24 25 26 27 OutputPage0 PRV1_PV DB31 DBD338 ATF Pr...

Page 92: ...rt or first scan 6 OutputPage0 DB31 DBX366 6 7 OutputPage0 DB31 DBX366 7 56 0 OutputPage0 PB_ATF_START_STOP DB31 DBX367 0 AFT Start Stop Byte 1 OutputPage0 PB_ATF_Ack_Alarms DB31 DBX367 1 ATF Acknowledge Alarms 2 OutputPage0 PB_Reset_Counters DB31 DBX367 2 Algorithm Performance Counters Reset 3 OutputPage0 PB_ATF_Control_Mode DB31 DBX367 3 Control Mode 4 OutputPage0 PB_ATF_Slope_Enabled DB31 DBX36...

Page 93: ..._Alarm_2 DB31 DBX312 6 P2 High High Pressure Alarm 7 3 OutputPage1 P2_PV DB31 DBD480 ATF Pressure at P2 PSI Bar Real 4 5 6 7 OutputPage1 PRV1_PV DB31 DBD484 ATF Pressure at PRV1 PSI Bar Real 8 9 10 11 OutputPage1 PRV2_PV DB31 DBD488 ATF Pressure at PRV2 PSI Bar Real 12 13 14 15 OutputPage1 P3_PV DB31 DBD492 ATF Pressure at P3 PSI Bar Real 16 17 18 19 OutputPage1 P4_PV DB31 DBD496 ATF Pressure at P...

Page 94: ... AIW18_Cal_Accept_Vis DB31 DBD510 0 1 DB31 DBD510 1 2 DB31 DBD510 2 3 DB31 DBD510 3 4 DB31 DBD510 4 5 DB31 DBD510 5 6 DB31 DBD510 6 7 DB31 DBD510 7 34 35 OutputPage1 PFLOWSP DB31 DBD512 Pressure Flow Setpoint LPM LPM Real 36 37 38 39 OutputPage1 PTIMESP DB31 DBD516 Pressure Flow Setpoint Time SEC Real 40 41 42 43 OutputPage1 EFLOWSP DB31 DBD520 Exhaust Flow Setpoint LPM LPM Real 44 45 46 47 Output...

Page 95: ...556 Flow Driving Force Offset for Switching BAR PSI Real 18 19 20 21 OutputPage2 Press_Cycle_Delay_Time_SP DB31 DBW560 Pressure Cycle Delay Time SP Int 16 22 23 OutputPage2 Press_Cycle_Over_Time_SP DB31 DBW562 Pressure Cycle Over Time SP Int 16 24 25 OutputPage2 Pres_Cycl_PV_Step_Size DB31 DBD564 Pressure Cycle PV Step Size Real 26 27 28 29 OutputPage2 EDFOFST DB31 DBD568 Exhaust Driving Force Off...

Page 96: ...3 PTIMEMAXSP DB31 DBD612 Max Pressure Flow Setpoint SEC Real 12 13 14 15 OutputPage3 PTIMEMINSP DB31 DBD616 Min Pressure Flow Setpoint SEC Real 16 17 18 19 OutputPage3 ETIMEMAXSP DB31 DBD620 Max Exhaust Flow Setpoint SEC Real 20 21 22 23 OutputPage3 ETIMEMINSP DB31 DBD624 Min Exhaust Flow Setpoint SEC Real 24 25 26 27 OutputPage3 PV1MAX DB31 DBD628 Flow Proportional Valve Max Value Real 28 29 30 3...

Page 97: ... 2 PRV2 Cal Select Button 3 OutputPage4 P3_Cal_Enable DB31 DBX666 3 P3 Cal Select Button 4 OutputPage4 P4_Cal_Enable DB31 DBX666 4 P4 Cal Select Button 5 OutputPage4 P5_Cal_Enable DB31 DBX666 5 P5 Cal Select Button 6 OutputPage4 W1_Cal_Enable DB31 DBX666 6 W1 Cal Select Button 7 DB31 DBX666 7 4 5 OutputPage4 P2_P1_EU DB31 DBD668 P2 First Point Cal Engineering Units PSI Bar Real 6 7 8 9 OutputPage4...

Page 98: ...ing Units PSI Bar Real 54 55 56 57 OutputPage4 W1_P2_EU DB31 DBD720 W1 Second Point Cal Engineering Units KG Real 58 59 60 61 0 OutputPage4 P2_P1_Capture DB31 DBX724 0 1 P2_P2_Capture DB31 DBX724 1 2 P2_Accept DB31 DBX724 2 3 PRV1_P1_Capture DB31 DBX724 3 4 PRV1_P2_Capture DB31 DBX724 4 5 PRV1_Accept DB31 DBX724 5 6 PRV2_P1_Capture DB31 DBX724 6 7 PRV2_P2_Capture DB31 DBX724 7 62 0 OutputPage4 PRV...

Page 99: ... Flow Calculated Cycle Time Real 4 5 6 7 OutputPage5 FACT DB31 DBD732 Flow Actual Cycle Time Real 8 9 10 11 OutputPage5 ECCT DB31 DBD736 Exhaust Calculated Cycle Time Real 12 13 14 15 OutputPage5 EACT DB31 DBD740 Exhaust Actual Cycle Time Real 16 17 18 19 OutputPage5 TRENDTIME DB31 DBD744 Trend Time Base Real 20 21 22 23 OutputPage5 S2TMREAL DB31 DBD748 STATE 2 Timer Real 24 25 26 27 OutputPage5 S...

Page 100: ...V Example configuration This example shows a Siemens CM 1242 5 card slave module being added to a Delta V controller configuration 1 1 Install the GSD File in Delta V Explorer Open under the DeltaV_System Library Device Definitions Profibus Devices Select Add Device Definition ...

Page 101: ...TM ATF System with C410 V4B Controller User Guide 97 1 2 Add new Profibus Device Open under the DeltaV_System System Configuration Physical Network Control Network VIM I O C01 P01 Select New Profibus Device ...

Page 102: ...e Type Select the correct Profibus Type Generated by the GSD file In this case a Siemens CM 1242 5 card is shown 1 4 Address Setting Verify that the Enabled checkbox is checked and the Address field matches the Address set on the Admin page on the HMI 1 5 Confirm and Select OK button ...

Page 103: ...V4B Controller User Guide 99 1 6 Verify Enabled If this is the first device on the Profibus Card reopen the port and verify that the enabled checkbox is checked 1 7 Create Slot Create a New Profibus Slot for the new Profibus Device ...

Page 104: ...t 1 Module number 1 needs to be a 64 Byte Output or XCell ATF controller Inputs Slot 2 Module number 2 needs to be a 64 Byte Input or XCell ATF controller Outputs 1 9 Verify Communications are functioning With the systems powered up and the Profibus cables connected comms can be established and confirmed Siemens Indication Green LED s illuminate on the slave device s even if signals are not create...

Page 105: ... In the Delta V Slot create a New Profibus Signal 1 11Create a Real datatype tag For a REAL tag to be read from the XCell ATF controller select the Data Type Floating Point Standard network Byte order should be checked for Siemens to provide the correct endian order for Delta V ...

Page 106: ... V4B Controller User Guide 102 This Appendix is intended to provide some limited guidance to an experience Delta V controls professional to avoid standard configuration inquiries which has been experienced by previous integrators ...

Page 107: ...dding for Process Control Since OLE is based on the Windows COM Component Object Model standard under the hood OPC is essentially COM Over a network OPC relies on DCOM Distributed COM which was not designed for real time industrial applications and is often set aside in favor of OPC tunneling OPC is implemented in Server Client pairs The OPC Server is a software application that bridges the commun...

Page 108: ... is in remote control mode and the selector switch is set to OPC Unlike the Profibus communications which is divided into several pages all OPC parameters are contained within one datablock and each parameter can be sent individually When programming commands to the ATF controller it is recommended to leave parameters at their previous values to avoid sudden changes 1 3 Output Signals to Master fr...

Page 109: ...meters remotely If the XCell ATF is changed from Remote Control Mode to Local Control Mode it continues to run and it is possible to stop the run from the HMI If the filtration has been stopped locally and then changed back to Remote Control Mode it will not restart To restart the filtration the master has to perform the items listed in Remote Start described earlier in this section System stop If...

Page 110: ...ation can be performed by the PLC This calculation is initiated by setting an accept bit momentarily asserted Controller performs the linear scaling calculation and resets the controller s internal calibration enable bit Calibration Example Technician calibrates the P2 pressure sensor 1 Assert enable bit a Set P2_Cal_Enable input command bit 1 until P2_Cal_Enable output response bit is set 1 and i...

Page 111: ...the value on the external pressure gauge 5 Pressure gauge reading is provided to the controller a Programmer provides another data entry location for technician to enter the pressure value b Set P2_P2_EU the pressure value from the data entry location c Set P2_P2_Capture 1 until the P2_Cal_Enable bit is received When true d Reset P2_P2_Capture 0 the maximum capture bit is momentarily asserted 6 As...

Page 112: ...Cycle_Delay_Time_SP DB41 DBW56 Pressure Cycle Delay Time SP Stroke Int DB41 Press_Cycle_Over_Time_SP DB41 DBW58 Pressure Cycle Over Time SP Stroke Int DB41 Pres_Cycl_PV_Step_Size DB41 DBD60 Pressure Cycle PV Step Size Stroke Real DB41 EDFOFST DB41 DBD64 Exhaust Driving Force Offset for switching bar PSI Real DB41 Vac_Cycle_Delay_Time_SP DB41 DBW68 Vacuum Cycle Delay Time SP Stroke Int DB41 Vac_Cyc...

Page 113: ...0 Bool DB41 W1_P1_Capture DB41 DBX155 1 Bool DB41 W1_P2_Capture DB41 DBX155 2 Bool DB41 W1_Accept DB41 DBX155 3 Bool DB41 Force_Solenoid DB41 DBX155 4 Bool DB41 PV1_SP DB41 DBD156 Real DB41 PV2_SP DB41 DBD160 Real DB41 PRV1_SP DB41 DBD164 Real DB41 PRV2_SP DB41 DBD168 Real DB41 P2_P1_EU DB41 DBD172 Calibration AIW04 Point 1 Engineering Value bar Real DB41 P2_P2_EU DB41 DBD176 Calibration AIW04 Poi...

Page 114: ... DB40 DB40_DataLog DL_EFLOWSP DB40 DBD340 Exhaust Flow Setpoint LPM LPM Real DB40 DB40_DataLog DL_EFLOWMAXSP DB40 DBD344 Max Exhaust Flow Setpoint LPM LPM Real DB40 DB40_DataLog DL_EFLOWMINSP DB40 DBD348 Min Exhaust Flow Setpoint LPM LPM Real DB40 DB40_DataLog DL_PTIME DB40 DBD352 Pressure Flow SEC SEC Real DB40 DB40_DataLog DL_PTIMESP DB40 DBD356 Pressure Flow Setpoint SEC SEC Real DB40 DB40_Data...

Page 115: ... DB40 DB40_DataLog DL_Press_Cycle_Over_Time_SP DB40 DBW506 Pressure Cycle Over Time SP SEC Int DB40 DB40_DataLog DL_Vac_Cycle_Delay_Time_SP DB40 DBW508 Vacuum Cycle Delay Time SP SEC Int DB40 DB40_DataLog DL_BATCH_NO P DB40 DBX0 0 Batch Number String DB40 ATF_HeartBeat DB40 DBX512 0 ATF Heartbeat 1 Sec Cycle 50 Duty Bool DB40 Rem_PB DB40 DBX512 1 ATF Remote Profibus Master Bool DB40 Rem_OPC DB40 D...

Page 116: ...DBX544 2 Bool DB40 AIW04_Cal_Enabled DB40 DBX544 3 Bool DB40 AIW04_Cal_Accepted_Vis DB40 DBX544 4 Bool DB40 AIW06_Cal_Enabled DB40 DBX544 5 Bool DB40 AIW06_Cal_Accepted_Vis DB40 DBX544 6 Bool DB40 AIW08_Cal_Enabled DB40 DBX544 7 Bool DB40 AIW08_Cal_Accepted_Vis DB40 DBX545 0 Bool DB40 AIW12_Cal_Enabled DB40 DBX545 1 Bool DB40 AIW12_Cal_Accepted_Vis DB40 DBX545 2 Bool DB40 AIW14_Cal_Enabled DB40 DB...

Page 117: ... Command Word ATF Start ATF_START Command Word ATF Stop ATF_STOP Command Word Acknowledge Alarms AFT_Ack_Alarms Command Word ATF Control Mode Flow Time ATF_Control_Mode Command Word ATF Slope Enable ATF_Slope_Enabled Connected Bioreactor INT number ATF_ConnectedBR Pressure Flow Setpoint LPM PFLOWSP Pressure Flow Setpoint SEC PTIMESP Exhaust Flow Setpoint LPM EFLOWSP Exhaust Flow Setpoint SEC ETIME...

Page 118: ...SEC PTIMEMINSP Max Exhaust Flow Setpoint SEC ETIMEMAXSP Min Exhaust Flow Setpoint SEC ETIMEMINSP Flow Prop Valve Max Value PV1MAX Flow Prop Valve Min Value PV1MIN Exhaust Prop Valve Max Value PV2MAX Exhaust Prop Valve Min Value PV2MIN Flow Regulator Max Value bar PRV1MAX Flow Regulator Min Value bar PRV1MIN Exhaust Regulator Max Value bar PRV2MAX Exhaust Regulator Min Value bar PRV2MIN Calibration...

Page 119: ...int 1 Engineering Value P5_P1_EU Calibration AIW16 Point 2 Engineering Value P5_P2_EU Calibration AIW18 Point 1 Engineering Value W1_P1_EU Calibration AIW18 Point 2 Engineering Value W1_P2_EU The audit trail file is recorded on the SD card in the form of a csv file This file can be viewed in Siemens Audit Viewer and includes a validity check to show in Audit Viewer that the file has not been opene...

Page 120: ...TF 4 XCell ATF 6 XCell ATF8 and XCell ATF 10 system operation has been assessed for compliance with applicable CE Directives A sample Declaration of Conformity certificate is shown below Please note that this sample is provided as an example only and is subject to change A copy of the Declaration of Conformity is included with the equipment ...

Page 121: ...ibly with thefollowing information Name and address of the manufacturer Rated voltage full load amperage and frequency Serial number Short circuit Interrupting rating of the equipment Designation of series or type The weight of the equipment CE mark Identification number of the electrical schematics Year of construction Sample controller nameplates are shown below ...

Page 122: ...em and the Controller o Inspect air and vacuum connections to the controller o Inspect that all components inside of the controller are secured and intact o Inspect enclosure for damage locks and hinges for performance o Inspect the XCell ATF system housing components especially the internal and sealing surfaces for damage rust cracks scoring o Perform a pressure hold test of the XCell ATF System ...

Page 123: ...supplier follows UL guidelines and builds enclosures to UL508A standards for industrial control panels intended for general industrial use operating from a voltage of 600 volts or less A label on the inside of the C410 controller power box displays the UL Listing Mark This label is purchased through UL and serial numbered controlled Presence of this label is proof that representative samples of th...

Page 124: ... S7 1200 C2410 E AX CPU SIMATIC S7 200 CPU module XCell ATF 6 Pneumatics Spares C410 P6 RF PM Pressure Manifold for C410 6 C410 P6 RF EM Exhaust Manifold for C410 6 C410v2 P48 RF SOL1 ASSEMBLY 3 way valve SOL1 for C410 v1 v2 XCell ATF4 XCell ATF6 XCell ATF8 Controller C410 P KN PR 0 60 REGULATOR 0 60PSI C410 P 1 5VG 1 5 Vacuum Gauge 0 30 Hg CENTER BACK 1 8 NPT 7216 1 1 8 30 0 FLANGE MOUNT Replaces...

Page 125: ...Sanitary 6 0 TC TC BRB1 Sanitary Adapter 3 4 Tri Clamp x 1 4 Hose Barb Fitting XCell ATF6 AIR ASSY Air Inlet Assembly XCell ATF6 P3 CPM1 5 TC3 4 Kit PT 1 5 CPM Fitting 3 4 TC XCell ATF6 PH AA AIR Air Hemisphere XCell ATF6 w XCell ATF6 AIR ASSY XCell ATF 10 Pump Housing Spares A10 STAND Stand Assembly XCell ATF10 A10RF C3 ASME Clamp Assembly XCell ATF10 A10RF H1 Filter Housing Assembly XCell ATF10 ...

Page 126: ... 2 13 XCell ATF10 ASME Monel Heavy Hex Nut 1 2 13 XCell ATF10 NUT FIN 1 2 13 XCell ATF10 ASME Monel Fine Hex Nut 1 2 13 A ST TS A ST TS Thumb Screw for XCell ATF10 XCell ATF8 Base XCell ATF10 AIR ASSY Air Inlet Assembly XCell ATF10 XCell ATF10 PH AA AIR Air Hemisphere XCell ATF10 w XCell ATF10 AIR ASSY P3 CPM1 5 TC3 4 Kit PT 1 5 CPM Fitting 3 4 TC For additional service support please contact Repl...

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