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Introduction to HoloMonitor® M4
HoloMonitor M4 is a live cell imaging time-lapse cytometer, providing imaging and quantifi-
cation of unstained living adherent cells directly in their culture vessels. It can be used for
a wide range of applications, including:
•
Cell count and proliferation
•
Cell culture quality assessment
•
Cell morphology
•
Cell motility and migration
•
Cell division/mitosis
•
Toxicology
HoloMonitor is based on digital holography microscopy. This technique is based on measure-
ments of how the cells shift the phase of light that passes through the cells, and does not
require any kind of labeling or staining.
HoloMonitor is incubator compatible, allowing experiments to be performed in a cell culture
incubator or a hypoxia chamber. The cells can be analyzed while growing undisturbed in a
range of different cell culture vessels, see
.
HoloMonitor is equipped with a fixed sample
stage, or with a computer-controlled motorized
XYZ-stage.
Applications are described in application notes,
such as cell motility, cell death, cell cycle and
toxicology. Application notes are available at
www.phiab.se/publications/application-notes
and associated protocols at