ELC-03XS User Manual
_________________________________________________________________________________________________________________
___________________________________________________________________________
version 2.2
page 5
Today three methods are used to record electrical
in vivo
or
in vitro
:
Recordings using patch (suction) electrodes from single neurons
Whole cell patch clamp technique (tight seal recording, intracellular)
Loose patch technique (loose seal recording, extracellular)
Intracellular recordings with sharp microelectrodes
Extracellular recordings with glass or metal electrodes
The amplifiers used for such recordings are specialized on the recording of the potentials or
currents generated by the neurons under investigation. If these recording methods are
combined with dye injection, electroporation, stimulation protocols etc. through the recording
electrode, serious constraints occur and several additional devices have to be added to the
experimental set-up.
The ELC series of amplifiers fills this gap. It allows intracellular, extracellular, voltage –
clamp or current clamp recordings both with sharp or patch electrodes as well as additional
protocols like electroporation or juxtasomal recordings. Even iontophoresis and
voltammetry/amperometry can be performed.
The ELC amplifier is the “Swiss Army Knife” of modern electrophysiology. It is easy to use,
versatile, and makes possible a lot of sophisticated experiments with only one instrument.
