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Agilent Technologies 708-DS, Operator'S Manual

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Agilent Technologies 708-DS Operator'S Manual Download Page 47

47

Agilent Technologies

708-DS / 709-DS Dissolution Apparatus
Operator’s Manual

 

4
Operating the 708-DS / 709-DS

Main Screen - Options

48

Menu Screen - System Menu

67

General 708-DS / 709-DS Conventions

96

Agilent 708-DS / 709-DS Notifications

100

Summary of Contents for 708-DS

Page 1: ...Agilent Technologies 708 DS 709 DS Dissolution Apparatus Operator s Manual ...

Page 2: ... that conflict with these terms the warranty terms in the separate agreement shall control Technology Licenses The hardware and or software described in this document are furnished under a license and may be used or copied only in accordance with the terms of such license Restricted Rights Legend U S Government Restricted Rights Soft ware and technical data rights granted to the federal government...

Page 3: ...ions Used in this Manual 17 Serial Number Format 18 3 Setting Up the 708 DS 709 DS 19 Initial Setup 20 Unpacking Procedure 20 Environmental Requirements for Installation 22 Clearance 22 Equipment Parts and Accessories As Shipped 23 Parts and Accessories 23 Tubing Cable Connections 24 Heater Circulator Setup 708 DS 24 Instrument Level Water Bath Setup 25 Level Instrument 25 ...

Page 4: ...llation 709 DS 33 Vessel Installation 34 Sample Manifold Installation 35 Accessory Installation 37 Setting Basket Apparatus 1 Heights 43 Setting Paddle Apparatus 2 Heights 44 4 Operating the 708 DS 709 DS 47 Main Screen Options 48 Main Screen Display Parameters 48 Main Screen Sample Temperatures 49 Main Screen Run 50 Main Screen Stop 57 Main Screen Drive Unit Up Down 59 Manual Drive Unit Up Down 6...

Page 5: ...Entry 97 Parameter Limits Ranges 98 Agilent 708 DS 709 DS Notifications 100 Main Screen Error Conditions 100 Dialog Screens Green Blue 102 Warning Screens Yellow 104 Error Screens Red 109 5 Maintenance and Troubleshooting 115 Preventive Maintenance 116 Weekly Maintenance 116 Monthly Maintenance 116 Bi Annual Maintenance 116 Sample Line Paddle Basket Care 117 Shafts 117 Baskets 118 Rinsing Sample L...

Page 6: ...g Cannulas Probes 125 Manifold Maintenance 125 Removing the Manifold 125 Accessing the Top Cover 126 Removing Top Cover 126 Replacing the Top Cover 126 Printer Maintenance 127 Removing a Thermal Paper Roll 127 Inserting a Thermal Paper Roll 5095 0307 130 Thermal Printer Test 133 Obtaining Warranty and Other Services 134 Index 135 ...

Page 7: ...on 35 Figure 13 Connecting AutoTemp 36 Figure 14 Affixing the Fasteners 37 Figure 15 Proper Sample Tubing Position 38 Figure 16 Installing Evaporation Covers on Shafts 39 Figure 17 Shaft Locking Collars 39 Figure 18 Dosage Delivery Module and Alignment Post 40 Figure 19 Inserting DDM into DDM Alignment Shaft 41 Figure 20 Attaching DDM to Alignment Post 42 Figure 21 Accessory Installation 43 Figure...

Page 8: ...ll 127 Figure 31 Accessing the Printer Handle 128 Figure 32 Open Printer Chamber 128 Figure 33 Removing the Thermal Paper Roll 129 Figure 34 Inserting a Thermal New Paper Roll 130 Figure 35 Leading Paper and Closing the Lid 131 Figure 36 Closing the Printer Chamber 131 Figure 37 Feeding Paper 132 Figure 38 Printer Test 133 ...

Page 9: ...le 7 Menu Screen Instrument Settings Screen 2 84 Table 8 Menu Screen Instrument Settings Screen 3 85 Table 9 Menu Screen Instrument Settings Screen 3 86 Table 10 Menu Screen Diagnostics Screen 1 90 Table 11 Menu Screen Diagnostics Screen 2 92 Table 12 Diagnostics DVH Diagnostics Screen 1 93 Table 13 Numeric and Time Date Entry 97 Table 14 Parameter Limits Ranges 98 Table 15 Dialog Screens Green Bl...

Page 10: ...10 708 DS 709 DS Operator s Manual Tables This page was intentionally left blank except for this message ...

Page 11: ...o personnel or severe damage to equipment and property Information on safety practices is provided with your instrument and operation manuals Before using your instrument or accessories you must thoroughly read these safety practices Observe all relevant safety practices at all times Electrical Hazards The dissolution apparatus contains electrical circuits devices and components operating at dange...

Page 12: ...iously damage the instrument and any attached ancillary equipment Always use a three wire outlet with ground connection which is adequately rated for the load The installation must comply with local state and federal safety regulations Do not connect the instrument to the main power supply until you have made sure that the operating voltage is correctly set for the main power supply in the specifi...

Page 13: ... could result in death or injury Read all warnings and cautions carefully and observe them at all times Caution CAUTION A Caution message appears in the manual when failure to observe instructions could result in damage to equipment Agilent supplied and or other associated equipment Note NOTE A Note appears in the manual to give advice or information ...

Page 14: ...cates that this product must not be disposed of as unsorted municipal waste All Agilent products that are subject to the WEEE directive shipped after August 13 2005 are compliant with the WEEE marking requirements Such products are marked with the crossed out wheelie bin WEEE symbol in accordance with European Standard EN 50419 For more information on collection reuse and recycling systems please ...

Page 15: ...15 Agilent Technologies 708 DS 709 DS Dissolution Apparatus Operator s Manual 2 Introduction Conventions Used in this Manual 17 Serial Number Format 18 ...

Page 16: ...ting vessels with Agilent s Direct Vessel Heating DVH Each apparatus can be tailored to support several innovative features designed to allow unattended dissolution testing including Dosage Delivery Module DDM AutoTemp and Auto Sampling WARNING The dissolution apparatus contains electrical circuits devices and components operating at dangerous voltages Contact with these circuits devices and compo...

Page 17: ...tion 2 708 DS 709 DS Operator s Manual 17 Conventions Used in this Manual Items you are asked to press are in bold For example press H on the keypad Key sequences you are asked to press appear like this MENU 7 ...

Page 18: ...ins 10 characters and follows this syntax CC1234xxxx Syntax Code Meaning Description CC Country of origin 2 alpha characters matching the required trade designation for the country of origin 12 Year of manufacture 09 for 2009 10 for 2010 etc 34 Week of manufacture 01 for week 1 to 52 for week 52 ...

Page 19: ...9 DS Dissolution Apparatus Operator s Manual 3 Setting Up the 708 DS 709 DS Initial Setup 20 Equipment Parts and Accessories As Shipped 23 Tubing Cable Connections 24 Instrument Level Water Bath Setup 25 Agilent 708 DS 709 DS Setup 33 ...

Page 20: ... DS Operator s Manual 3 Setting Up the 708 DS 709 DS Initial Setup Complete the following sections to initially set up the Agilent 708 DS 709 DS and all other system components Unpacking Procedure Figure 1 Unpacking ...

Page 21: ...9 DS Operator s Manual 21 1 Remove the Agilent 708 DS 709 DS and all other system components from the packing material Figure 2 Removing the Apparatus 2 Inspect the equipment and accessories to ensure there has been no damage during shipment ...

Page 22: ...Temperature 5 ºC to 40 ºC Power 115 230 V ac 50 60 Hz 2 5 A Main supply voltage fluctuations are not to exceed 10 of the nominal supply voltage Clearance 1 Prepare the area where the equipment is to be located 2 Ensure a minimum clearance of 30 cm above the unit when fully raised and 10 cm at the rear and on both sides of the Agilent 708 DS 709 DS Approximately 82 cm x 82 cm total bench space is r...

Page 23: ...oller Communication Cable 709 DS 3 Fin Baskets 709 DS Bath Temperature Probe 708 DS Thermal Printer Paper External Vessel Temperature Probe optional 17 mm Open end Wrench Power Cord s 90 º Allen Key for Level Adjustment Manifold Arm Labels Shaft Locking Collars 6 pin Cable for Heater Circulator Vessel Centering Tool Bath Temperature Probe Thermal Printer Paper Rinse Cups or Tray 7 64 T handle Alle...

Page 24: ...ed BATH HEATER on the dissolution apparatus rear panel Figure 3 BATH HEATER Connector CAUTION Do not turn on the heater circulator before filling the water bath to avoid damaging the internal heating elements of the circulator NOTE The Agilent Wide Input Range Heater Circulator is pre installed on the apparatus at the factory If reinstallation or replacement is required please refer to the Agilent...

Page 25: ...S 709 DS 3 708 DS 709 DS Operator s Manual 25 Instrument Level Water Bath Setup Complete the following sections to properly level the instrument and fill the water bath Level Instrument Figure 4 Levelers and Stability Feet ...

Page 26: ...ck caps from the five 5 screws located on the front side and rear of the base plate of the dissolution apparatus Figure 5 Level Adjustment Screw Caps 2 Raise the side stability feet located toward the back on either side of the base plate so they are not touching the laboratory bench ...

Page 27: ...he rear level adjustment screw adjust the screw to achieve front to back level within tolerance It may be necessary to lift the heater circulator to gain access to this screw 5 Verify the level of the dissolution apparatus with a bubble or digital level 6 Once the unit is leveled use the open end wrench to tighten the nut s below the base plate 7 Lower the side stability feet located toward the ba...

Page 28: ...eath the vessel plate Ensure that the rubber feet of the control box do not sit in any holes on the vessel plate 2 Connect the cable attached to the vessel plate to the circular input on the DVH Power Controller box 3 Connect the communication cable RJ 45 from the DVH Power Controller box to the DVH Comm port on the back of the drive unit Figure 7 DVH Power Controller ...

Page 29: ...1 Insert the water bath temperature probe into the BATH TEMP jack on the rear of the dissolution apparatus drive unit Figure 8 BATH TEMP Connector 2 Place the other end of the temperature probe through the hole in the center of the vessel plate in the water bath Figure 9 Positioning the Temperature Probe ...

Page 30: ...y connections of power cords to all components 2 Plug the cords into electrical outlets of the appropriate voltage 708 DS 709 DS Initial Power Up 1 Turn on the power of the dissolution apparatus using the switch located on the left side of the drive unit 2 Ensure the self test conducted upon initialization passes which is indicated by a green check mark CAUTION Ensure the correct voltage has been ...

Page 31: ...press and hold Drive on the Main screen to allow for access to the water bath 2 Fill the water bath to an appropriate level with purified water using the label affixed to the bath as a guide Be sure to allow for displacement of the water once the dissolution vessels are installed Figure 10 Filling the Water Bath ...

Page 32: ... begins To release air trapped in the pump or heater cartridge follow the priming instructions located on the heater circulator 3 Repeat the procedure if necessary 4 Ensure no leaks are present at any of the tubing connections NOTE Use ultrapure water when possible to minimize scale and mineral buildup Use algaecide to inhibit mold and bacteria and algae growth Check the label to ensure the formul...

Page 33: ... position between the vessel plate and the base plate of the 709 DS 2 Ensure the center peg on the bottom surface of each chamber aligns with the hole in the base plate 3 Locate the isolation chamber mirrors and place one in the bottom of each of the cylinders NOTE The wiring on the underside of the vessel plate should be avoided during chamber installation To accomplish this begin by installing t...

Page 34: ...e 709 DS vessel open the clip install the vessel and close the clip 4 If necessary place the TruAlign blank vessel position covers on the vessel plate openings at Position 7 and Position 8 Rotate the two clips for each position over the cover to secure it in place NOTE Bubbles on the surface of the vessel like the one centered in the figure below are not a manufacturing defect and will not affect ...

Page 35: ...ure the left and right alignment shafts are also positioned correctly Figure 12 Positioning the Manifold for Installation 3 Push the manifold up into the drive unit until resistance is met 4 While gently lifting upward press Load from within the Manifold Control box The internal drive should slowly lift the manifold to its fully raised position 5 If the unit is equipped with AutoTemp attach the tw...

Page 36: ...oTemp 6 If the unit is equipped with autosampling locate the black sample tubing fasteners and attach the fastener to the sample tubing wrap 7 If applicable affix the fasteners to the underside of the drive unit A fastener is affixed to the left and to the right of the center drive unit lift ...

Page 37: ...09 DS evaporation covers Dosage Delivery Modules DDMs alignment posts receptor shafts paddle shafts basket shafts and shaft locking collars 2 If necessary press and hold Drive to move the drive unit to its fully raised position 3 If applicable insert a receptor shaft spin on off shafts only into each spindle location 4 Slide an evaporation cover onto the shafts to be installed and insert the shaft...

Page 38: ... 708 DS 709 DS Operator s Manual 3 Setting Up the 708 DS 709 DS Figure 15 Proper Sample Tubing Position NOTE Ensure that all sample tubing is behind the shaft and clear from all cables See Figure 15 below ...

Page 39: ... 708 DS 709 DS Operator s Manual 39 Figure 16 Installing Evaporation Covers on Shafts 5 Place a shaft locking collar on the top of each shaft and slide in down until it rests on top of the drive unit Figure 17 Shaft Locking Collars ...

Page 40: ...09 DS Operator s Manual 3 Setting Up the 708 DS 709 DS 6 Insert a DDM or alignment post into the DDM Alignment Shaft hanging from the underside of the drive unit Figure 18 Dosage Delivery Module and Alignment Post ...

Page 41: ...nual 41 Figure 19 Inserting DDM into DDM Alignment Shaft 7 Repeat the previous step for all applicable positions 8 Attach the DDM or alignment post to the evaporation cover by aligning the notch with the locking pin of the cover and pushing until fully seated ...

Page 42: ...g Up the 708 DS 709 DS Figure 20 Attaching DDM to Alignment Post 9 Repeat the previous step for all applicable positions 10 Ensure that the sampling port of the evaporation cover is aligned properly with the sample manifold probes if applicable ...

Page 43: ...eight gauge provided onto the bottom of the basket shaft 3 Lower the drive unit to its operating position until it stops 4 With the shaft locking collar loosened carefully lower the shaft until the bottom of the basket height gauge rests against the bottom of the vessel 5 Ensure the shaft locking collar is flush against the top of the spindle assembly by rotating each shaft until resistance is met...

Page 44: ...he drive unit until sufficient clearance is available to move the basket height gauge to the next position 8 Repeat steps 2 7 for all remaining positions Setting Paddle Apparatus 2 Heights 1 Ensure the drive unit is fully raised and the paddle shafts are pushed up sufficiently 2 Place a 25 mm height sphere in each vessel ...

Page 45: ...locking collars loosened carefully lower each shaft until the bottom of the paddle blade rests against the height sphere 5 Ensure the shaft locking collar is flush against the top of the spindle assembly by rotating each shaft until resistance is met 6 Tighten each shaft locking collar securely 7 Raise the drive unit to its home position 8 Remove the height spheres from the vessels ...

Page 46: ...46 708 DS 709 DS Operator s Manual 3 Setting Up the 708 DS 709 DS This page was intentionally left blank except for this message ...

Page 47: ...ologies 708 DS 709 DS Dissolution Apparatus Operator s Manual 4 Operating the 708 DS 709 DS Main Screen Options 48 Menu Screen System Menu 67 General 708 DS 709 DS Conventions 96 Agilent 708 DS 709 DS Notifications 100 ...

Page 48: ...09 DS Main Screen Options The following sections detail the operations available from the 708 DS 709 DS Main screen Main Screen Display Parameters The Main screen displays the system status and is updated once per second Figure 24 Main Screen Display Parameters ...

Page 49: ...the displayed RPM to quick set the spindle speed Upon pressing this area the numeric data entry screen displays Enter a valid number to change the RPM and press Ok to return to the Main screen The spindle speed changes only if the spindle was previously running If the spindle was idle it starts Similarly if you press the area over the displayed temperature you can quick set the bath temperature Up...

Page 50: ...ts in a beep The Bath temperature remains displayed as Press Printer to print the temperatures If no printer is installed the printer icon is not displayed Press Close to close the window and return to the Main screen Main Screen Run When you press Run the Select Start Type screen displays From the Select Start Type screen Press Method to select a method Press Manual to start manual operation Pres...

Page 51: ...ect Method Automated You can enter up to five automated methods through the Select Method screen In order to select a method to run press the number of the method Selecting a method takes you to the Start Options screen Press Return to return to the Select Start Type screen ...

Page 52: ... selected Bath Temperature The method starts once the water bath has reached its selected start temperature 708 DS only Manual Dosage Place a check in this box to indicate dosage forms will be introduced manually A visual display will appear on screen indicating when the user should drop dosage forms into each vessel DVH Preheat This option is enabled for the 709 DS Direct Vessel Heating Each test...

Page 53: ...en DVH Preheat Hold Enable this option to delay start of the test after temperature stabilization A screen will appear prompting the user to begin once vessel temperature has stabilized Without this option the test will begin immediately after the preheat cycle 709 DS only Time Delayed Displays the Date and Time screen The apparatus begins monitoring appropriate temperatures at the entered time an...

Page 54: ...5 ºC 0 1 ºC Spindle Speed 10 0 250 0 RPM 0 1 RPM Media Volume 100 to 2000 mL Depends on configuration Test Duration 000 00 10 to 999 59 59 1 second Profile Print Interval 000 01 00 to 024 00 00 1 second DDM Increment 000 00 00 to 001 39 59 1 second Apparatus Type 1 2 5 or 6 Function Manual Dosage Place a check in this box to indicate dosage forms will be introduced manually A visual display will a...

Page 55: ...l Operation screen The Main screen displays and the following actions take place The Manually Insert Dosage s dialog box displays Load Dosage Prompt on page 105 If DDMs are installed tablets are automatically dropped into the vessels simultaneously or sequentially based on the DDM Increment For example a DDM Increment of 5 seconds drops the first tablet immediately the second tablet 5 seconds afte...

Page 56: ... the temperature is out of tolerance The displayed system date and time are updated once per second The measured rotational spindle speed and bath vessel temperature s are displayed at an update rate of once per second Run is relabeled Stop If a printer is installed test data is periodically printed based on the Profile Print Interval The test stops when the elapsed time equals the Test Duration U...

Page 57: ... running the Stop button is displayed When you press Stop the Pause Method screen displays When this screen displays the currently running method or manual test continues to run until you select an option You have the option of pausing or stopping the test or canceling this dialog and returning to the ...

Page 58: ...used screen displays When a method is paused the system takes the following actions The spindles stop If Full Media Change has been selected as a method parameter the elapsed time counter stops counting A Pause Elapsed Time counter starts counting If the paused time exceeds the time specified in the Pause Duration Alarm the Alarm warning screen displays See Pause Duration Exceeded on page 110 ...

Page 59: ...elapsed time is reset to zero The bath is maintained at the last entered temperature The time date and the message TEST ABORTED BY USER are sent to the printer Main Screen Drive Unit Up Down Press Drive to raise the drive unit as long as the button is held Release Drive to stop the motion Press Drive to lower the drive unit Double tap Drive to allow the drive unit to raise to its highest position ...

Page 60: ...rive Unit Up Down The manual lift is controlled by a knob on the right side of the instrument To adjust the position of the drive unit loosen the knob and raise or lower to the desired position Tighten the knob to secure the drive unit in position Figure 25 Manual Lift Knob ...

Page 61: ...709 DS is not equipped with the Auto Sampling option for unattended sample collection you will have to retrieve the samples manually The evaporation cover design provides easy access to the appropriate dissolution sampling zone with the traditional manual sampling cannula Figure 26 Taking a Manual Sample ...

Page 62: ...andard Evaporation Cover Main Screen Manifold Up Down Press Manifold to raise the manifold to its highest position You do not need to hold the button to fully raise the manifold Press Manifold to lower the manifold to the lowest position for the currently specified apparatus type Setting the proper manifold depth for the appropriate volume and apparatus combinations is specified in Menu Screen Cal...

Page 63: ...k the instrument press The Lock the instrument screen displays Enter the access code confirm it and press Ok The instrument returns to the Main screen and the Instrument Locked icon is displayed Further changes to the instrument are prohibited until the instrument is unlocked or the power is cycled ...

Page 64: ...ment press The Unlock the instrument screen displays requesting an access code Enter the access code and press Ok The instrument returns to the Main screen and displays indicating that the system is unlocked Full functionality of the instrument is now available through the front panel NOTE If you forget your access code the only way to regain access is to cycle the power ...

Page 65: ...e screen the Run Stop button is not displayed and the screen is locked Although all other buttons are displayed they are disabled Main Screen Alarms The alarm functions are accessed by pressing on the Main screen This notification applies only to the basic Timer Alarm function The icon is displayed only if a Timer Alarm duration has been entered and the timer duration has not elapsed ...

Page 66: ...ventative Maintenance Instrument Calibration Due on page 104 Once the warning has been acknowledged the icon displays as a reminder until the maintenance occurs This icon is displayed on the Main screen until the appropriate due date has been updated under Menu Calibration See Menu Screen Calibration Screen 1 on page 87 NOTE The Timer Alarm is provided as a convenience and does not affect the runn...

Page 67: ...available through this screen Method Editor Reports Alarms Instrument Calibration and Diagnostics is described in detail in the following sections Method Editor Menu Screen Method Editor on page 68 Reports Menu Screen Reports on page 77 Alarms Menu Screen Alarms on page 80 Instrument Menu Screen Instrument on page 82 Calibration Menu Screen Calibration on page 87 Diagnostics Menu Screen Diagnostic...

Page 68: ...to create a new method enter new method parameters or modify an existing method Forty slots are allocated for storage of methods in system memory In order to create a new method select an empty memory slot which is indicated by dashes in the name field Tap an available method or slot The Method Properties screen displays ...

Page 69: ...e of the bath during a test Spindle Speed Desired speed of the spindle during a test Media Volume Volume of media in each vessel during a test Rotation Start Delay Amount of time in seconds between the start of the test and the start of spindle rotation maximum value of 10 seconds Apparatus Type Currently installed apparatus Full Media Change If this option is enabled the elapsed time counter stop...

Page 70: ...lect Method screen Press Save to save the values to permanent memory and return to the Select Method screen Press Next to save all values to permanent memory and proceed to the next Method Properties screen Method Properties Screen 2 Table 3 Method Properties Screen 2 Option Function Enable Final Spin Enables the final spin Final Spin RPM Allows for spindle rotation at a speed different from the p...

Page 71: ...urn to the Select Method screen Press Next to save all values to permanent memory and proceed to the next Method Properties screen DDM Increment This is the time in seconds between successive tablet drops Tablets are dropped starting with position one and continuing through the highest position installed 6 or 8 Profile Print Interval This parameter controls the frequency that the spindle speed and...

Page 72: ...Enables recording and printing of the initial test temperature Final Temp Enables recording and printing of the final test temperature Manifold Down Lead Time This is the amount of time that the manifold lowers prior to the sample time point This allows for equilibration of the temperature probes before vessel temperature measurement and for priming the system when an external pump is connected Ma...

Page 73: ...the next Method Properties screen Enable Sample Point Alarm Enabling this option activates the sample notification dialog as well as activating the audible and visual alarms This alarm draws the operator to the machine at the timepoint for manual sampling scenarios Alarm Lead Time The Time Point Approaching screen Time Point Approaching on page 102 is available to notify the user of upcoming time ...

Page 74: ...es and recording of data occur Specify a time point by pressing the button for the corresponding time point The Timepoint Properties screen displays requesting the new spindle speed and time for when that time point will be executed You can enter a different RPM and vessel volume at each time point The run report will print out the RPM that was running immediately before the time point At the spec...

Page 75: ... to exit without saving the values and return to the Select Method screen Press Back to save all values to permanent memory and return to the previous Method Properties screen Press Save to save all values to permanent memory and return to the Select Method screen NOTE If a time point overlap is noted during time point entry a warning icon displays in the lower left of the Method Properties Timepo...

Page 76: ...e screen displays when Cancel is pressed from one of the Method Properties screens This option allows you to return to the Method Editor if Cancel is pressed inadvertently From the Are you sure screen Press Yes to return to the Select Method screen Press No to return to the current Method Editor screen ...

Page 77: ...DS 709 DS Operator s Manual 77 Menu Screen Reports If a printer is installed check Enable Printer to enable all printer functions Un check the box to disable printing To print results from the last completed test press Last Run Results ...

Page 78: ... contents of a method press Print Method The Select Method screen displays prompting you to select a method to print Available methods have a name associated with them Methods that have not yet been configured have a series of dashes in the name field indicating available memory ...

Page 79: ...ng the 708 DS 709 DS 4 708 DS 709 DS Operator s Manual 79 Press Print Instrument Settings to print all of the instrument configuration parameters and their current values Press Ok to return to the Menu screen ...

Page 80: ...arm Time Expired on page 106 and an audible alarm sounds This alarm sounds until you press Ok To cancel a previously running alarm before time has expired enter 0 for the Timer Alarm value Pause Duration This field allows you to set the maximum pause period while running a method When a running method is paused a timer starts If the pause time exceeds this Pause Duration the Pause Duration Exceede...

Page 81: ...g the 708 DS 709 DS 4 708 DS 709 DS Operator s Manual 81 From the Alarms screen Press Ok to enable the Timer Alarm and return to the Menu screen Press Cancel to discard any changes and return to the Menu screen ...

Page 82: ...nformation during a test Comm ID The address of the instrument on the communications bus This address is used by external host programs to communicate with the instrument The Comm ID may range from 01 to 99 All Position Spin Allows the spindle to rotate regardless of the position of the drive unit This is useful when calibrating spindle speed as the spindle may rotate while the drive unit is in it...

Page 83: ... calibration routine The screen prompts you to press three different circles in succession to calculate the calibration To verify calibration press the 4 circles in the screen corners Multiple Xs normally display in each circle Touchscreen calibration values are stored in permanent memory for further use If the touchscreen calibration was entered inadvertently do not touch the screen After a 5 sec...

Page 84: ...method Vessels This parameter sets the current installed vessel size 2000 mL 1000 mL 200 mL or 100 mL This is used to set user prompts in other places throughout the operation of the instrument Number Active Sets the number of vessels used in a test For example a 6 vessel configuration may only use the first four vessels if this parameter is set to 4 The remainder of the vessels are ignored until ...

Page 85: ...u screen Press Next to advance to the next Instrument Settings screen Menu Screen Instrument Settings Screen 3 From the Instrument Settings screen Press Back to return to the previous Instrument Settings screen Press Finish to save all settings and return to the Menu screen Table 8 Menu Screen Instrument Settings Screen 3 Option Function Manifold Configuration Selects the numbering scheme to be us...

Page 86: ...ument Settings screen Press Finish to save all settings and return to the Menu screen Table 9 Menu Screen Instrument Settings Screen 3 Option Function Bath Heating Energy Save Enable this option to program the power save feature for the heater circulator 708 DS only Heater circulator on and off times can be specified to conserve energy and reduce stress on the components of the unit ...

Page 87: ...tune the height of the manifold for Apparatus 1 Baskets and Apparatus 2 Paddles The volumes shown change based on the installed vessel size set in Instrument Setting Screen 2 Menu Screen Instrument Settings Screen 2 on page 84 The following vessel size ranges are configurable Size Max Min 2L 2000 mL 1650 mL 1L 900 mL 500 mL 200 mL 200 mL 150 mL 100 mL 100 mL 80 mL ...

Page 88: ... press Manifold or Manifold to raise or lower the manifold The manifold will move as long as the button is held The current location of the manifold is displayed above Manifold Once the desired position is reached press Save on the corresponding field This updates the display for that field From the Paddles Baskets Sampling Depth screen Press Restore Defaults to replace all of the displayed values...

Page 89: ...en to indicate that calibration or maintenance is required You must develop your own Calibration and Preventative Maintenance schedules From the Regulatory Calibration Date screen Press Cancel to exit the routine without saving the values and return to the Menu screen Press Back to save all values to permanent memory and return to the previous Calibration screen Press Finish to save all values to ...

Page 90: ...sired RPM Press Run to start the spindle and press Stop to stop the spindle The actual RPM displays in the gray block below the RPM set point Bath Allows control over the bath temperature Press the block next to Setpoint and enter the desired temperature in the open field that displays Press Ok to activate the temperature controller until the set point temperature is reached The actual temperature...

Page 91: ...ft it up while pressing Load Release the manifold once it begins to rise on its own Press Stop to stop all manifold motion Dosage Delivery Module Control The DDMs are solenoid activated doors that hold a tablet above each vessel Press the corresponding button to open a DDM Press All to open all DDMs simultaneously Drive Press Drive to raise the drive unit Keep pressing it to raise the drive unit t...

Page 92: ...he Menu screen Table 11 Menu Screen Diagnostics Screen 2 Option Function Print Test Sheet Sends a test message to the printer A printer is required for this option DVH Opens a new window with the operational parameters of the Direct Vessel Heating module If the DVH is not installed Agilent 708 DS this button is disabled Home Manifold Automatically returns the sample manifold to its home fully rais...

Page 93: ... fails a red X displays On systems with less than 8 vessels installed the extra positions remain blank From the DVH screen Press Ok to return to the main Diagnostics screen Press Test Single Vessel Lower heater or Test Single Vessel Both heaters to proceed to DVH Diagnostic Screen 2 Table 12 Diagnostics DVH Diagnostics Screen 1 Option Function Read Version Displays the firmware version of the DVH ...

Page 94: ...r heater for a vessel If Test Single Vessel Both heaters was selected on the previous screen press a button to turn on both heaters When a heater is active a green check mark displays in the corresponding vessel button Once the heaters are turned on the value of the RTD starts to increase as the temperature rises From the DVH screen Press Ok to return to the main DVH Diagnostics screen NOTE For sa...

Page 95: ...hanges to specific instrument settings and method parameters Three levels of access are provided Administrator Advanced User User From the User Level Settings screen Press Ok to return to the previous window NOTE You can customize each user access level but changes can only be made when the instrument is in Administrator mode ...

Page 96: ...trument The left arrow functions as a backspace key Spaces periods and dashes are provided as usable characters From the Data Entry screen Press CLEAR to remove all characters from the open field Press Ok to return to the previous window The data entered is returned and placed in the appropriate data entry box Press Cancel to clear the entered data and return to the previous window ...

Page 97: ...low the display The maximum valid data string length is 25 characters Special function keys are defined below From the Numeric and Time Date Entry screen Press Ok to return to the previous window The data entered is returned and placed in the appropriate data entry box Table 13 Numeric and Time Date Entry Option Function Backspaces and deletes one character every time it is pressed Used as separat...

Page 98: ...9 1 second Run Manual Operation 708 DS on page 54 Method Properties Screen 3 on page 72 Final Spin Duration 000 00 10 to 001 00 00 1 second Method Properties Screen 2 on page 70 Tester ID 12 characters Menu Screen Instrument Settings Screen 1 on page 82 Comm ID 01 to 99 01 Menu Screen Instrument Settings Screen 1 on page 82 Media Volume 100 to 2000 mL 1 mL Run Manual Operation 708 DS on page 54 Me...

Page 99: ...erties Screen 3 on page 72 Sample Point Alarm 000 00 05 to 000 02 30 1 second Method Properties Screen 3 on page 72 Method Pause Time 00 00 to 1 00 00 1 second Menu Screen Alarms on page 80 Timer Alarm 00 00 to 24 00 00 1 second Menu Screen Alarms on page 80 Table 14 Parameter Limits Ranges Parameter Range Resolution Configured ...

Page 100: ...dialog box with the corresponding error message to be displayed More critical errors are displayed on a separate error screen These errors may include the following Bath temperature out of tolerance Bath probe open circuit Bath probe short circuit Heater probe open circuit Heater probe short circuit Heater to bath probe offset 6º For this error it is important to disable the heater to prevent pote...

Page 101: ...l 101 If an error occurs during a test you must clear the error screen manually Clearing the error screen also clears the audible alarm If a printer is installed and alarms are enabled in the Instrument Settings the error condition is printed for record keeping ...

Page 102: ...been selected Method Start Options on page 52 Press the box beside either the Date or Time prompts to display the Numeric and Date and Time Entry screen Numeric and Time Date Entry on page 97 Press Cancel to abort the process and return to the previous screen Method Completion The Method Completion screen displays when a method has completed The total elapsed time current date and time the method ...

Page 103: ...tor s Manual 103 Staggered Manual Drops The Staggered Manual Drops screen provides a visual indication of when to drop tablets for manual introduction Preheat Complete Displays when the preheat process has completed Table 15 Dialog Screens Green Blue ...

Page 104: ...e Warning This Method Warning screen displays when an Auto Sampling Manifold is installed and enabled Method Properties Screen 3 on page 72 If the sum of the Manifold Down Duration and Manifold Lead Time Method Properties Screen 3 on page 72 are less than 30 seconds this screen displays Press Ok to clear the warning Invalid Initial Temperature Warning This Method Warning screen displays only when ...

Page 105: ...s 6 rotating cylinder They indicate that it is time to attach the samples to the shafts A manual drive unit displays the second warning and an apparatus with an automated drive unit displays the third warning Press Ok to clear the dialog and continue the run Drive displays only on units equipped with an automated drive unit Temperature Sampling Notification This warning displays only when an Auto ...

Page 106: ...ics Press Ok to return to the Diagnostics screen Preheating Notification This warning displays during preheating for Vessel or Bath selected start options The warning changes to reflect the current configuration of the system Current bath or vessel temperatures are displayed during preheating Press Cancel to abort the run and return to the Main screen Alarm Time Expired Displays when the Timer Ala...

Page 107: ...ent Warning Applies to systems with automated drive units It indicates that you must move the drive unit to its lowest position to continue a run Press Ok to lower the drive unit to its lowest position Press Cancel to abort the current method and return to the Main screen Temperature Probe Open Warning Indicates that one or more temperature probes have failed A red X is placed in the appropriate s...

Page 108: ...lowered position If the drive unit is not fully lowered the apparatus beeps and the warning remains on screen Once the drive unit is in the fully lowered position press Ok to continue the run Press Cancel to abort the current run Raise Drive Unit Notification Displays on systems with manual drive units Manual Drive Unit Up Down on page 60 It indicates when it is permissible to raise the drive unit...

Page 109: ...ta Error The Invalid Data Error screen displays when unexpected data is encountered Press Ok to clear the error String Length Exceeded The Data Entry Error displays when a parameter has exceeded the maximum number of characters for that field The minimum and maximum number of characters are displayed Press Ok to clear the dialog Method Complete with Errors This error displays after a method has co...

Page 110: ...hen the pause duration alarm time has been exceeded Menu Screen Alarms on page 80 Press Ok to clear the dialog Vessel Temperature Error Displays when a vessel temperature has exceeded the allowable tolerance range Menu Screen Instrument Settings Screen 2 on page 84 The vessel temperatures are displayed in blue if they are within tolerance They are red if they are outside the allowed tolerance rang...

Page 111: ...cable is connected Check cable Heater Air Pocket or Heater OFF The heater circulator temperature is more than 6 C hotter than the bath temperature probe indicating an air pocket or stagnant hot water in the heater element Follow the priming procedure on the back of the Wide Input Range Heater Circulator Bath Temperature 2 ºC Over Setpoint Check for a faulty probe Contact Agilent Customer Care Obta...

Page 112: ...f the drive belt and severe deterioration of the spindle motor Contact Agilent Customer Care Obtaining Warranty and Other Services on page 134 Autosampling Manifold Errors The Stepper Motor Errors screen shows all of the possible errors associated with the manifold stepper motor A red X displays before the current error condition If a stepper motor error is encountered the current run is stopped Y...

Page 113: ...unication attempts with the DVH and abort the operation Methods do not run until DVH communications have been established Press Retry to attempt to establish communication again If normal DVH communication is restored the unit returns to normal operation DVH Error 709 DS This DVH Error screen displays at the beginning of each method or manual test start Main Screen Run on page 50 when an error in ...

Page 114: ...114 708 DS 709 DS Operator s Manual 4 Operating the 708 DS 709 DS This page was intentionally left blank except for this message ...

Page 115: ...ator s Manual 5 Maintenance and Troubleshooting Preventive Maintenance 116 Sample Line Paddle Basket Care 117 Vessels and Evaporation Covers 121 Water Bath and Temperature Probes 708 DS 122 Manifold Maintenance 125 Accessing the Top Cover 126 Printer Maintenance 127 ...

Page 116: ...d clean it thoroughly Refill the bath and add algaecide Bi Annual Maintenance 1 Remove the top cover 2 Inspect the spindle drive belt for wear fraying and tension 3 Check that the spring loaded belt tensioner is maintaining pressure on the belt and is not loose CAUTION Ammonia bleach alcohol and other solvents can cause deterioration of the plastic Use only cleansers approved for plastic materials...

Page 117: ...se deionized water whenever possible If you must use a cleanser or solvent be sure that it is as mild as possible non abrasive and fully compatible with fluorocarbons and stainless steel before use If in doubt call the service department for advice before proceeding We recommend that you do not use a laboratory dishwasher Clean paddles and basket shafts only by hand The high temperatures to which ...

Page 118: ... cleansers or cloths especially if they re gold or PTFE coated non stick Mesh openings on baskets could enlarge which could have an effect on results Use deionized water whenever possible If you must use a cleanser or solvent be sure that it is as mild as possible non abrasive and fully compatible with fluorocarbons and stainless steel before use If in doubt contact the service department for advi...

Page 119: ...ne rinsing after each test A rinse tubing kit 17 1341 or rinse tray is provided to conveniently flush the sample tubing Rinse Tubing Kit 1 Attach one end of the lines of the rinse tubing kit to the sample cannulas and place the other in a container of an appropriate rinsing solution 2 Activate the pumping mechanism to properly flush the tubing lines Rinse Tray 1 Raise the drive unit of the 708 DS ...

Page 120: ...dispose of the rinsing solution 10 Lower the shafts to their appropriate location Rinse Cups Optional If the Agilent 708 DS 709 DS is configured with a sampling manifold the sample lines require a routine rinsing after each test Easy to attach rinse cups are available to make the flushing of the tubing simple and efficient 1 Fill the rinse cups with the cleaning solution desired and attach a cup t...

Page 121: ...f the cup rests on either the paddle blade or the basket clip attachment 3 Activate the pump configured with the system until the tubing loop is sufficiently cleansed 4 Finally detach the rinse cups place them in their transport tray dispose of the waste and rinse the cups to be ready for their next use ...

Page 122: ...55 C should be avoided All electrical contact surfaces are gold plated to provide excellent corrosion resistance Your DVH vessel is highly water resistant meaning it may be cleaned with routine manual glassware cleaning procedures and allowed to dry Similar to water resistant watches or electrical devices this does not mean it is waterproof which means the vessel should not be deeply submerged pre...

Page 123: ...lkhead fitting and unscrew the elbow fitting 3 If the outlet to the bath is leaking remove the tubing and unscrew the T fitting from the left bottom side of bath 4 Inspect the bulkhead fitting gaskets for damage and replace them if necessary 5 Remove old PTFE tape from all male fittings Inspect threads for damage and replace the elbow of the T fitting if necessary 6 Apply new PTFE tape to the male...

Page 124: ...ch as NIST 1 Place the probe into a water bath with a known temperature and allow several minutes for the probe to equilibrate 2 The resistance is measured by attaching the leads of the multi meter to the top and shank of the inch phone plug 3 Refer to the table on Page page 124 to find the resistance value of the probe at the bath temperature Temperatures between the values listed may be interpol...

Page 125: ...Maintenance and Troubleshooting 5 708 DS 709 DS Operator s Manual 125 Figure 29 Resistance Value of Temperature Probe ...

Page 126: ... of a button The initial installation procedure is described in Sample Manifold Installation on page 35 For the purposes of cleaning maintenance or just to create additional space for manual testing the manifold may be ejected from the drive unit To remove the manifold follow these steps 1 Lift the drive unit to its fully raised position 2 Disconnect the two thermistor RS232 cables if AutoTemp is ...

Page 127: ...ft and right side screws from bottom sides of cover 4 If a printer is installed in the top cover lift the cover up approximately six inches and remove the two cable connectors from the printer inside 5 Remove the cover away from the instrument Replacing the Top Cover 1 If a printer is installed in the top cover reconnect the cable connectors to the printer inside the cover 2 Press the cover down i...

Page 128: ...ar empty Paper Roll NOTE A red line on the side of the paper roll indicates the paper supply is almost exhausted Replacement is recommended when the red line is visible If the paper roll is not changed and the paper supply is exhausted the 708 DS 709 DS gets an out of paper signal from the printer and displays an error on the screen ...

Page 129: ...tor s Manual 129 1 Place fingers underneath the light colored handle and pull forward to pop out the front of the printer Figure 31 Accessing the Printer Handle Opening the chamber reveals the paper roll or empty core inside Figure 32 Open Printer Chamber ...

Page 130: ...bleshooting 2 Internal side levers hold the roll in place Since it is empty or nearly empty use your fingers to pull out the small roll or core Figure 33 Removing the Thermal Paper Roll NOTE The empty core is disposable Each new roll includes a cardboard core ...

Page 131: ...e paper so the leading edge of the paper feeds from over the roll and not from under it Figure 34 Inserting a Thermal New Paper Roll 2 Lead the paper out for a few inches and close the top lid of the chamber NOTE Only a 58 mm wide x 25 meter maximum thermal printer paper roll with a 13 mm core size can be used in the panel mount printer For an FDA environment it must also meet the ten year retenti...

Page 132: ...d 3 Keeping the paper centered close the bottom lid of the chamber and snap it into place Figure 36 Closing the Printer Chamber 4 To verify that the paper is not skewed or jammed press the upper right hand button on the printer to feed some paper If paper does not feed re open the chamber and re center the paper ...

Page 133: ...Maintenance and Troubleshooting 5 708 DS 709 DS Operator s Manual 133 Figure 37 Feeding Paper ...

Page 134: ...Operator s Manual 5 Maintenance and Troubleshooting Thermal Printer Test In the second Diagnostics screen press Print Test Sheet to print sample text and verify the printer is functioning properly Figure 38 Printer Test ...

Page 135: ...nd Other Services To place a service order warranty or other services please contact your local Customer Care Center Contact information can be found at www agilent com under your country using the Contact Us link Place your service request using the displayed phone number or E mail address ...

Page 136: ...136 708 DS 709 DS Operator s Manual 5 Maintenance and Troubleshooting ...

Page 137: ...lphanumeric 96 Dialog Delayed Start 102 Delayed Start Date Time 102 Method Completion 102 Time Point Approaching 102 Dialog Screens 102 E Entry Numeric and Time Date 97 Equipment 23 Error Autosampling Manifold 112 Bath Heater 111 Bath Temperature 110 Fatal Spindle 112 Invalid Data 109 Method Complete 109 Parameter Out of Range 109 Pause Duration Exceeded 110 Spindle Speed 112 String Length Exceede...

Page 138: ... Rinse Cup 120 Shaft Locking Collars 39 Taking a Manual Sample 61 Tightening the Shaft Locking Collar 44 Unpacking 20 H Heater Circulator Power up 32 Setup 24 I Initial Power Up 30 Initial Setup 20 Installation Accessory 37 Instrument Level 25 L Level Instrument 25 Re verification 32 Limits Ranges Parameter 98 M Main Screen Alarms 65 Display Parameters 48 Drive Unit Up Down 59 Error Conditions 100...

Page 139: ...6 Removing 126 Replacing 126 Tubing 24 U Unpacking Procedure 20 V Vessel Installation 34 W Warning Alarm Time Expired 106 Automated Drive Unit Movement 107 Instantaneous Spindle Speed Jump 106 Instrument Calibration Due 104 Instrument Preventative Maintenance Due 104 Invalid Initial Temperature Warning 104 Load Dosage Prompt 105 Lower Drive Unit Notification 108 Out of Paper Notification 107 Prehe...

Page 140: ...138 708 DS 709 DS Operator s Manual Index This page was intentionally left blank except for this message ...

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