Chapter 2
Using the Controller
21
Indirect Blood Pressure Measurements
in Small Animals using Tail Cuffs
Background Information
This technique has been used routinely for the non-invasive measurement of
blood pressure in rats, and more recently in mice. The technique provides a
good estimate of actual systolic pressure. Although non-invasive, the protocol
details related to the technique (warming, handling, restraint and so on) will
inevitably have some effect on the actual blood pressure. The technique is
useful as a comparative measurement, particularly when carried out on a well-
habituated animal.
The major advantage of the PowerLab approach to this technique is that it
provides an accurate and permanent record of the pulsatile data recorded
from the tail during the measurement cycle. It therefore makes it possible for
scientists to develop protocols and detection algorithms that correlate with
their experiment. We do not offer a method of estimating diastolic pressure,
because to date very little published data is available on the efficacy of such
methods.
Cuff Inflation
Cuff Deflation
Figure 2–3
Typical recording using
LabChart showing the
pulse and pressure signals
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