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Page 8  

47650 Instruction Manual (Rev. 2.1)

 

  

 

Flip them up by the tail, 
right-side up but dorsal 
side  in  first,  and  then 
drop them between the 
rotating  discs  onto  the 
rotor. 

 

 

Figure 4 

“Placing the Mice on the 

Rotor

 

 

IMPORTANT

:  

The mice should not be lowered from above; if an attempt is made to place 
the  animal  directly  on  the  rotor,  it  will  spread  its  legs  and  block  entry 
between the discs.  

Experience and patience will teach the ideal technique: as in most  behavioural devices, 
the  man/  animal  interface  is  not  less  important  than  the  animal/  machine  one,  and 
requires some patience and gentle handling to be perfected. 

Speaking  about  animal/machine  interface,  the  surface  finishing  of  the  drums  is  a 
sensitive  point.  The  rotor  drums  are  knurled  to  provide  adequate  grip.  Soft  substances 
are not suitable, as the mice would cling to the drums without trying to keep pace with the 
revolving  rotor  as  the  experiment  dictates;  knurled  Perspex  provides,  according  to  our 
experience, the ideal compromise, and remains spotless after years of use. 

If you have the feeling that the rotor surface is too glossy and smooth, brush its knurled 
surface with a metallic brush; this action will not make the surface texture coarser, but it 
creates thousands of micro scratches which eventually improve the grip.  

Summary of Contents for 47650

Page 1: ...UGO BASILE S R L sales ugobasile com service ugobasile com www ugobasile com instruction manual Rotarod Mouse Cat No 47650 E C T Unit Cat No 57800...

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Page 3: ...ED TO ENSURE SAFE OPERATION AND TO RETAIN THE INSTRUMENT IN SAFE CONDITIONS SERVICE AND ADJUSTMENTS SHOULD BE CARRIED OUT BY QUALIFIED PERSONNEL AUTHORIZED BY UGO BASILE ORGANIZATION ANY ADJUSTMENT MA...

Page 4: ...TION MANUAL MANUALE DI ISTRUZIONE X PAD SOFTWARE SOFTWARE DATE Serial No IMBALLATO DA PACKED BY Set for 115V 50 Hz 230V 50 Hz 115V 60 Hz 230V 60 Hz IMPORTANT IMPORTANTE Check the shipment for complete...

Page 5: ...PPLYING POWER 5 3 5 1 MAINS SWITCH 6 3 5 2 FUSE HOLDER 6 3 5 3 MAINS CORD 6 3 6 INTENDED USE 6 3 7 ADDITIONAL SAFETY CONSIDERATION 6 3 8 CONNECTIONS 7 3 8 1 USB HARD DISK 7 3 8 2 KEYBOARD 7 3 9 INSTAL...

Page 6: ...D 22 5 8 SIGNAL OUTPUT 22 5 8 1 PIN OUT 22 6 MAINTENANCE 23 6 1 ELECTRICAL 23 6 2 CLEANING 23 6 3 LONG INACTIVITY 24 6 4 CUSTOMER SUPPORT 24 7 47650 SPECIFICATIONS 24 8 ORDERING INFORMATION 25 8 1 OPT...

Page 7: ...the trip box below the plate boxes and the corresponding magnetic switch is activated thereby recording the animal endurance time in seconds The display shows the actual angular speed RPM At the end o...

Page 8: ...tes a 4 3 touch screen for basic setting and monitoring via an intuitive panel The picture shows the Rota Rod main menu Figure 1 Main Menu During the test the touch screen indicates the actual speed R...

Page 9: ...is dependent on the conductive nature of human body it doesn t work if the user is wearing gloves 2 2 Rota Rod Features The main features of the new model are SPEED adjustable in the range 3 80 RPM in...

Page 10: ...r in full version The software automatically classifies the data combining configuration settings with test results The user can add information before or after the test Results appear in a tree like...

Page 11: ...ownload on our web For any additional information and or assistance you are welcome to contact our Service Department see paragraph 6 4 Customer Support specifying the serial number of your instrument...

Page 12: ...raph 8 ORDERING INFORMATION 2 immediately disconnect and replace damaged mains cord 3 do not obstruct a comfortable access to the power module 4 do not operate in hazardous environments or outside pre...

Page 13: ...ing and debug ETH the Ethernet connector will be used for remote diagnosis and Internet access used for standard operation 3 8 1 Hard Disk The device hard disk is now embedded in the inside electronic...

Page 14: ...e one and requires some patience and gentle handling to be perfected Speaking about animal machine interface the surface finishing of the drums is a sensitive point The rotor drums are knurled to prov...

Page 15: ...It advisable to carry out an acclimation and training session before starting the motor co ordination test With the rotor at low speed say 4 5 R P M each na ve mouse is placed upon its section in orde...

Page 16: ...logo button always brings back to the Home page 5 1 1 System Icons NEW SOFTWARE DETECTED if this icon is present a new version of SW has been detected on the USB Key ETHERNET DETECTED an Ethernet conn...

Page 17: ...Depress the keybord icon to activate the virtual keyboard Enter a maximum of 12 characters in each field TREATMENT PROTOCOL STAGE and TRIAL are text boxes where it possible to specify the related info...

Page 18: ...ing the related button at the page bottom Having selected the Speed and mode press to go back to the Home page 5 3 1 Constant Speed With Constant Speed mode the rod rotates CCW at a speed which remain...

Page 19: ...by a phase at decreasing speed a change of rotation hence a CW rotation phase at increasing speed followed by a phase at decreasing speed The scheme on the right simplifies the re verse cycle Depress...

Page 20: ...then repeating the cycle until stopped number In the example the rotor will revolve repeatedly 5 times forward then 5 times backward Depress the icon to activate the numeric keyboard to enter Speed b...

Page 21: ...2 Starting a Ramp In the accelerating mode when the RUN button is depressed the Rota Rod will pass from the IDLE state motor and counters disabled to the initial speed ALL Trip Boxes must be in the U...

Page 22: ...cating the completed revolutions the data are saved and will appear in the RESULT table As soon as the FINAL SPEED is reached the rod wil keep rotating at constant speed and the timers will continue c...

Page 23: ...and restart accelerating from INITIAL SPEED to FINAL SPEED The cycle is repeated until the STOP button is depressed at any time during the experiment When an animal falls off its rotor section tiltin...

Page 24: ...ated information entered by the user appear under the blue headings DATE TIME LANE TREATMENT ID PROTOCOL STAGE TRIAL The test results appear under the red headings LATENCY REVOLUTIONS SPEED MODE DISTA...

Page 25: ...at 5 6 2 Load Protocol When a USB flash drive containing at least one protocol is connected to the device the LOAD PROTOCOL button will open the following window displaying all the loadable protocols...

Page 26: ...Rota Rod C Insert the USB KEY containing RR_Update hex file into one of the two USB ports If the USB key is detected the icon on the system bar will appear on the tool bar If the system recognizes a n...

Page 27: ..._ 5 7 3 Diagnostics By selecting this function the Rota Rod will perform an self diagnostics automatic test First of all the machine tests the correct functioning of all trip boxes Follow the instruct...

Page 28: ...ion and speed The 15 pin D SUB connector see picture and paragraph 3 8 provides different output trigger in the form of TTL signals All pins except pin 8 are TTL digital signals Pin 8 is an analog out...

Page 29: ...E MAINS CORD BEFORE CARRYING OUT ANY MAINTENANCE JOB 6 1 Electrical To inspect and or replace the fuses disconnect the mains cable first Insert a miniature screwdriver in the slot indentation see para...

Page 30: ...istics ugobasile com sales ugobasile com Before sending any instrument to our factory for repair please contact our logistics department to obtain a return authorization number RMA and shipping packin...

Page 31: ...e Physical Total Weight 11Kg Shipping Weight 16Kg approx Dimensions 46 w x28 d x33 h cm Packing Dimensions 70x36x46cm Warranty 47650 is covered by a 24 month warranty 8 ORDERING INFORMATION 47650 Mous...

Page 32: ...Motor Neuron Improves Neuromuscular Function and Motor Neuron Survivain Mutant SOD1 Mice Neurobiol Of Aging 35 4 906 915 2014 M Milanese et alia Knocking Down Metabotropic Glutamate Receptor 1 Improve...

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Page 39: ...VALIDATION CERTIFICATE...

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