7.2
Perform system Cleaning-In-Place (CIP)
Maintenance interval
Perform a system CIP using when required, for example between runs where different
samples are used. This is important to prevent cross-contamination and bacterial growth
in the instrument.
Required material
The following materials are required:
•
Appropriate cleaning solutions (1 M NaOH, buffer solution, and distilled water).
•
Syringe, 25 to 30 mL
Introduction
The System CIP method is used to clean the flow path.
WARNING
Hazardous biological agents during run. When using hazardous
biological agents, run System CIP to flush the entire system tubing
with bacteriostatic solution (1 M NaOH) followed by a neutral buffer
before service, maintenance, and decommissioning.
CAUTION
Hazardous substances. When using hazardous chemical and bio-
logical agents, take all suitable protective measures, such as
wearing protective glasses and gloves resistant to the substances
used. Follow local and/or national regulations for safe operation,
maintenance and decommissioning of the equipment.
92
ÄKTA go Operating Instructions 29360951 AC
7 Maintenance
7.2 Perform system Cleaning-In-Place (CIP)
