Scale up calculations are done preferably by the membrane volume
as the calculation is most simple. Other methods for scale up via resi-
dence time will lead to similar result. Using the Sartobind nano 3 ml
the scale up factor for flow rate and binding capacity is equal to a
multiplication factor of membrane volumes of the listed scale up
device:
Device bed
Factor to increase Factor to increase
volume [ml]
flow rate
binding capacity
3
–
–
150
50
50
5000
1667
1667
28
