REPLIGEN TangenX SIUS PD, Руководство пользователя

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TangenX TM SIUS TM PD Filter Plate & 2-Bolt Clamp Assembly
User Guide
Identification IF.PUG.019
Revision R2
Approved
20-DEC-2018
7. CAUTION: Please be careful when tightening any tri-clamp connectors to the Filter Plate. It is
possible to crack the Filter Plate sanitary connection by squeezing it too tightly. Hand
tightening should be sufficient to any gaskets. In addition, any attached fitting packages should
be supported under one of the components to reduce or eliminate any torque effect on the
Filter Plate fitting. Simply put, long fitting runs consisting of tees with valves and gauges create
a lever that may cause the plastic Filter Plate connection to crack and/or break off.
8. Clean work area and in preparation for cassette installation. See next section for the applicable
sequence of events.
7. TangenX™ SIUS™ PD Cassette Installation
1. Filter Plate Insert is installed in clamp and ready for use.
2. Rinse the EPDM gaskets with deionized water or WFI. Place a rinsed gasket flat against the
bottom FPI; ensure that the holes in the gasket line up with the holes in the manifold.
3. Using scissors, carefully open the cassette bag to remove cassette.
WARNING: Each cassette is stored in 0.2M sodium hydroxide solution as a preservative.
Follow standard safety procedures for handling 0.2M sodium hydroxide,
including the use of gloves, safety goggles, and lab coat.
4. Place the cassette onto the Filter Plate Insert flat against the gasket. Place another gasket on
top of the cassette. Ensure that the holes in the manifold, gaskets, and cassette are completely
aligned. If you are using multiple cassettes, continue the same gasket/cassette/gasket pattern,
ending with a gasket between the last cassette, followed by the FPI Isolation Plate and 2BMC
top plate (see Figure 1.1).
5. Install the tie-rod spacers (if used) and washers on each bolt leaving a minimum of 18 mm (0.75
inch) of thread exposed on the rod. By hand, screw the nut on each bolt and hand tighten
evenly by alternating from one nut to the other. Bolts must be further tightened to within the
recommended torque values shown in Section 7 using a calibrated manual torque wrench.