Millipore Sigma Pellicon 3 Cassettes Скачать руководство пользователя страница 6

Pellicon

®

 3 Cassettes Installation and User Guide 

6

2.  On the first holder level (if there 

are more than one), remove the 

TC clamps and inserts holding the 

hydraulic cylinders to the clamp rods.

3.  Loosen and remove the hand wheels 

on the clamp rods at the opposite 

end plate (of the same holder level).

4.  Slide the end plate away from the 

manifold segment, creating an 

opening for cassette insertion into 

the holder.

5.  Slide the manifold adapter plate 

or a stainless steel support plate 

onto the holder against the holder’s 

manifold plate. 

6.  Slide a Pellicon

® 

 3 Cassette onto the 

holder. Up to ten 1.14 m

2

 cassettes 

may be installed per side if required.

7.  Slide the end plate back against the 

cassette assembly.

8.  Install the grooved clamp rods, TC 

clamps and inserts and the hand 

wheels. 

NOTE  The hand wheels require hand 

tightening only. Ensure that each 

end plate is flush against the 

cassette assembly and both hand 

wheels are snug against the end 

plate. Not less than one inch of 

excess thread on the clamp rod 

exiting the hand wheel should be 

exposed.

9.  Repeat the procedure for any other 

holder levels. 

Holder Pressurization and 

Operation

1.  The hydraulic fluid reservoir must be 

full (indicated on the level indicator 

inside the Hydraulic Power Unit).

2.  All hydraulic flex hose connections 

must be  installed from the 

Hydraulic Power Unit to the 

hydraulic cylinders.

3.  All hardware on the clamp rods 

must be in place. Tighten the hand 

wheels until they are hand-tight.

4.  Turn on the air supply to the 

Hydraulic Power Unit. A minimum 

of 80 psig air pressure should be 

available. Check the air pressure 

on the pressure gauge PI-1 on 

Hydraulic Power Unit front panel.

5.  The Power Switch on the Hydraulic 

Control Unit HS-1 must be in the 

ON position, and the green Power 

Indicator must be illuminated.

6.  Set the Operating Mode Selector 

Switch, HS-3 to RUN or STORE, as 

required.

7.  Set the System Mode Selector 

Switch, HS-2 to ENABLE. The 

hydraulic closure system will close 

the holder assembly and maintain 

the appropriate pressure on the 

holder for either RUN or STORE 

mode, as selected.

8.  To relieve hydraulic system pressure 

at any time, set the System Mode 

Selector Switch to DUMP or open 

the System Pressure Manual Dump 

Valve, MV-1 on the left side of the 

Hydraulic Power Unit.

Caution

 

The hydraulic closure system must 

remain connected to the holder 

during processing and during 

storage of installed cassettes. The 

hydraulic closure system must be 

depressurized before connecting 

or disconnecting fittings. If the 

position of the Operating Mode 

Selector Switch (RUN or STORE) 

is changed while the system is in 

ENABLE mode, the hydraulic system 

pressure will drop to 1000 psig 

and then increase to the correct 

pressure for the new selected mode. 

If the hydraulic system pressure 

drops below 1200 psig while in 

RUN mode or 800 psig while in 

STORE mode, the relevant Low 

Pressure Alarms (PAL-1 or PAL-2 

respectively) will be illuminated and 

the Alarm Horn will sound. Once 

the problem has been corrected and 

hydraulic pressure restored, the 

alarm condition may be cleared by 

pressing the Alarm Reset – Resume 

Operation Push-button.

Содержание Pellicon 3 Cassettes

Страница 1: ...ale Holder Installation 4 Hydraulic Process Scale Holder Installation 5 Maintenance 7 Flushing and Cleaning 7 Flushing 8 Cleaning 8 Sanitization 9 Depyrogenation 10 Integrity Testing 10 Measurement of...

Страница 2: ...TE Pellicon 3 88 cm2 and 0 11 m2 Cassettes must be installed in a Pellicon Cassette Holder Catalog Number XX42PMINI Holder Installation 1 Loosen the nuts on the tie rods of the holder and remove the n...

Страница 3: ...wipe 4 Slide the manifold adapter plate onto the holder against the holder s manifold plate with the solid light grey side labeled Manifold Side towards the manifold and the wings resting on the tie...

Страница 4: ...ary Tri Clover connection Pellicon Cassette hex nut washer stainless steel bushing handle PERMEATE RETENTATE FEED Pellicon10_2_06_2 eps Gasket Plate manifold adapter plate nut PERMEATE R E T E N T A T...

Страница 5: ...wrench and 15 16 in deep hex socket turn each nut 1 8 turn in the sequence shown in Figure 4 When the wrench clicks this indicates that the set force has been reached DO NOT OVER TORQUE Evenness of to...

Страница 6: ...d tight 4 Turn on the air supply to the Hydraulic Power Unit A minimum of 80 psig air pressure should be available Check the air pressure on the pressure gauge PI 1 on Hydraulic Power Unit front panel...

Страница 7: ...ut replacement of nuts and washers should be considered after every ten installations to maintain high sealing force in the holder 7 When new nuts do not spin freely refurbish the threaded rods with a...

Страница 8: ...se the tank drain valve V1 and the tank valve V2 2 Fill the tank with the flushing solution 3 Fully open the retentate valve V4 and permeate valve V5 if present and direct both the retentate and filtr...

Страница 9: ...iofilms Biopolymer Proteins and Polyphenolic Membrane Cleaning Agent Concentration Temperature C pH Time min Ultracel NaOH 0 1 N 0 5 N 25 50 13 13 7 30 60 Biomax NaOH 0 1 N 0 5 N 25 50 13 13 7 30 60 N...

Страница 10: ...c Acid 0 1M 30 50 1 30 NaOH 0 1N 25 50 13 30 Ultracel NaOH 0 1N 25 50 13 30 Use milder conditions if effectiveness of agent is still observed Better membrane life is expected with lower concentration...

Страница 11: ...l the tank with filtered deionized water water for injection or reverse osmosis permeate The flush water must be extremely pure to avoid fouling the membranes or introducing other contaminants into th...

Страница 12: ...0 40 0 734 75 2 24 1 023 46 4 8 1 551 102 2 39 0 748 73 4 23 1 047 44 6 7 1 598 100 4 38 0 762 71 6 22 1 072 42 8 6 1 648 98 6 37 0 777 69 8 21 1 098 41 0 5 1 699 Based on Water Fluidity Relative to...

Страница 13: ...ess compression and ensures that the units will not leak externally NOTE The storage agent used must comply with applicable local regulations Recommended Storage Solutions for Pellicon 3 Cassette Filt...

Страница 14: ...completely flushed Flush system and cassette System and cassette not completely cleaned Clean system and cassette Symptom Possible Cause Remedy High NWP Damage to membrane or cassette Integrity test...

Страница 15: ...xed below fluid air interface Vortex in feed container Add baffle to break vortex or reduce mixing speed Retentate splashing Fix retentate line below fluid in feed air interface container Pump cavitat...

Страница 16: ...atory matters to the best of our knowledge and ability but without obligation or liability Existing laws and regulations are to be observed in all cases by our customers This also applies in respect t...

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