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CRI values after blood replacement return to values consistent with those before blood loss (see
box and whisker plots in Figure 13 and Figure 14).
o
After blood replacement, the mean CRI value was 0.89 (95% confidence 0.89 to 0.9) with
a standard deviation of 0.076 (95% confidence 0.071 to 0.077).
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Linear mixed model analysis with CRI as the outcome and intravascular volume changes as the
predictor support the conclusion that M1s give consistent CRI estimates, even when they are
turned on and off.
o
There is no significant effect associated with using CRI estimates from different M1
devices (95% confidence).
o
Turning an M1 device on and off has no significant effect on CRI estimates (95%
confidence).
•
Linear mixed model analysis with CRI as the outcome and intravascular volume changes as the
predictor support the conclusion that CRI trends with changes in intravascular volume.
o
CRI trends with changes in intravascular volume (95% confidence).
Figure 13 - Box and Whisker plots of instantaneous CRI values, before blood loss, at maximum blood loss
–
Box and Whisker plots of instantaneous CRI values, before blood loss, at maximum blood loss
(at end of blood withdrawal for subjects completing ~20% blood volume withdrawal), during symptoms
(at end of blood withdrawal for subjects experiencing symptoms and not completing ~20% blood loss),
and after blood replacement. For each panel above, the number of subjects was 42, 32, 7, and 32,
respectively.
Figure 14 - Box and Whisker plots of one minute average CRI values, before blood loss, at maximum
blood loss
