Panlab 76-0770, Hardware User Manual, Page: 8 / 31

Rotarod
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5. INTRODUCTION
The LE8205 (76-0770), LE8305 (76-0771), LE8505 (76-0772) and LE8355 (76-0773)
ROTAROD units facilitate easy testing of motor activity in rodents. Drug
administration, central nervous system damage, disease effects on motor co-
ordination or fatigue can be assessed by measuring the time during which the animal
continues walking in a rotating rod.
Figure 1. LE8205 (76-0770) with rod for 5 mice
A central rod (made of Perspex, and knurled to provide adequate grip) divided in
sections, rotates at either a constant speed or a steadily accelerating rate (from 4 to
40 rpm in an interval of time ranged from 30 seconds to 10 minutes). The use of
acceleration has been reported to produce less variable data.