ELC-01MX User Manual
version 2.6
page 8
Today three methods are used to record electrically in vivo or in vitro:
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Recordings using patch (suction) electrode from single neurons
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Whole-cell patch clamp technique (tight seal recording, intracellular)
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Loose patch technique (loose seal recording, extracellular)
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Intracellular recordings with sharp microelectrodes
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Extracellular recordings with glass or metal electrodes
The amplifiers normally used for these types of measurements are specialized for the
recording of the potentials or currents generated by the neurons under investigation. If these
recording methods are combined with dye injection, electroporation, stimulation or other
electrical techniques that require multiple use of the recording electrode, additional constraints
are imposed on the experimental setup that may require the acquisition of additional
components.
The ELC series of amplifiers fills this gap. It allows intracellular, extracellular, voltage-clamp
or current clamp recordings both with sharp or patch electrodes as well as additional protocols
like electroporation or juxtasomal filling and amperometry / voltammetry methods. The ELC
amplifier is the “Swiss Army Knife” of modern electrophysiology. It is not only easy to use,
but it is also sufficiently versatile to enable the use of a single amplifier for many
sophisticated experiments.
