Chapter 3: Getting Started
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15
Original instructions
major components of the FreeZone Freeze Dry System that are susceptible to
degradation are as follows:
Acids
Buffers
Solvents
Component
Material
Ace
tic
Acid
2
0
%
F
o
rmic
Acid
T
rif
luo
ro
a
ce
tic
Acid
(T
F
A)
Ca
lcium
Chlo
ri
de
So
diu
m P
ho
sph
a
te
Ace
to
ne
Ace
to
nitt
irle
Ca
rbo
n T
et
ro
chlo
ride
Cy
clo
hex
a
ne
Dio
x
a
ne
M
et
hy
l t
-B
uty
l Ether
(
B
T
B
E
)
P
y
ridin
e
Valve Stem
Acetal
C
D
D
D
D
Collector
Lid
Acrylic
D
D
D
D
Hoses,
Gaskets &
Valve
Bodies
Neoprene
C
D
D
C
C
D
D
D
C
D
Flask Top
Silicon
Rubber
C
D
D
D
D
D
C
D
Chamber &
Fittings
Stainless
Steel
C
C – Moderate degradation; Limited use
D – Severe degradation; infrequent use recommended; immediate thorough
cleaning required.
Most common compounds used in freeze drying processes, if allowed to enter
the vacuum pump, will degrade the oil and cause damage to the vacuum pump.
Sugars and proteins typically will have minimal negative effect on any of the
materials of construction.
When using compounds in the Freeze Dryer that are hostile to the materials of
construction, it is imperative the equipment is thoroughly cleaned after use.
Rubber and plastic components that have been exposed to damaging
compounds should be removed and flushed with water.
The oil in the vacuum pump should be checked often. It must be changed if it
is cloudy, shows particles or is discolored. The useful life of vacuum pump oil
can be extended if the vacuum pump is operated for an extended period of time
after a freeze dry run. This allows contaminants to be purged from the hot oil.
This must be done with the inlet to the pump blocked off to prevent air from
free flowing through the pump. If the pump is operated at an elevated vacuum
level (> 10mbar), oil may be expelled from the pump and damage could occur.
