Media-Mate Plus Operation Manual
25-710-800-O
Deaeration Validation
Deaeration is validated by running a standard instrument cycle and then measuring the
dissolved oxygen content in each filled dissolution vessel. Dissolved Oxygen Meters are readily
available from laboratory suppliers such as Cole Parmer, (800) 323-4340.
To avoid dissolution problems, the maximum dissolved oxygen content should not exceed 95%
saturation at operating temperature (
Handbook of Dissolution Testing,
William Hanson, 3
rd
ed.
)
.
The USP Dissolution Toolkit recommends a dissolved oxygen level of not more than 6 ppm.
The Media-Mate Plus will meet this at 37 °C with 500 mL and higher volumes and/or
temperatures.
Deaeration Validation must be performed with all user-input adjustments set and recorded on
the Deaeration Validation Log. Validation is recommended for each set of user adjustments
that will be used. Validation is recommended prior to the first use of the instrument and should
be repeated every six months.
1.
Set all user-input adjustments (see
Section 7
).
2.
Initiate an instrument cycle (see
Section 7 – “Test Cycle”
).
3.
Using a Calibrated Dissolved Oxygen Meter, measure the dissolved oxygen content in
each dissolution vessel.
4.
Record all user-input adjustment settings and dissolved oxygen readings on the
Deaeration Validation Log.
Temperature Controller (PID) Set-Up
The Temperature Controller (see
Figure 6-3
) has been programmed at the factory to obtain
optimum temperature control and quick heat-up time. The program set points are locked and
should not require changing or resetting. If the factory program has been altered for any
reason, it may be restored in accordance with Hanson Research Corporation Procedure
Number 25-710-807, “Programming Procedures for Temperature Controller.” This procedure
is available on request from Hanson Research Corporation (see
Section 12
).
Figure 6-3: Temperature Controller
Section 6
Validation and Calibration
20
Summary of Contents for Media-Mate Plus
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