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The United States Pharmacopoeia Regulations establishes limits and calibration requirements for WFI (Water
For Injection). The
HI 5321
meter supports conductivity measurements that are needed for off line measurements
in a Stage 2 of the regulation. Stage 1 verification may be carried out in a container but the regulation requires
an in-line measurement. The meter provides prompts and instructions to make the measurements easily. Calibrate
an EC probe prior to starting USP analysis.
To access the USP menu:
• Select
from the basic display to select
.
• Press
then
.
• Select the
Direct/USP reading mode (see Conductivity Setup).
• Return to measure mode by pressing
.
• Verify conductivity probe has been calibrated in conductivity
standards in the lowest measurement range.
• Press
and then select the desired USP stage.
In this measure mode the user can check for water quality using
the United States Pharmacopeia standard (USP <645>) guidelines
for water for injection.
This USP standard consists of three stages (one in-line and two
off-line tests) as followings:
DIRECT/AUTOHOLD MEASUREMENT
To measure conductivity of a sample using the Direct/AutoHold
reading mode:
• Follow sample and probe directions found under
Direct
Measurement
.
• Select the
Direct/AutoHold reading mode (see Conductivity Setup).
• If pressing
, the “
AutoHold
” indicator will start
blinking on the display until the stability criterion is reached.
The conductivity value will be frozen on the display, along
with “
AutoHold
” indicator.
• To return to normal measure mode press
.
USP EVALUATION
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