29
SOURCE XT Clinical Data
Table 12:
SOURCE XT (High Risk)
Baseline Characteristics of the Patients and Echocardiographic Findings (AT Population)
Characteristic
Transfemoral
TA/TAo Pooled
(N = 1685)
(N = 995)
Age - yr
82.0 ± 6.5
80.3 ± 6.5
Male sex — no./total no. (%)
600/1685 (35.6%)
536/995 (53.9%)
STS score†
8.0 ± 6.8
7.9 ± 6.2
Logistic EuroSCORE
‡
19.8 ± 11.6
21.6 ± 13.7
NYHA class — no./total no. (%)
I/II
377/1676 (22.5%)
242/992 (24.4%)
III/IV
1299/1676 (77.5%)
750/992 (75.6%)
Coronary artery disease — no./total no. (%)
667/1685 (39.6%)
518/995 (52.1%)
Previous myocardial infarction — no./total no. (%)
205/1685 (12.2%)
197/995 (19.8%)
Previous intervention — no./total no. (%)
CABG
204/1685 (12.1%)
226/995 (22.7%)
PCI
460/1685 (27.3%)
355/995 (35.7%)
Balloon aortic valvuloplasty
128/1685 (7.6%)
66/995 (6.6%)
Cerebral vascular disease — no./total no. (%)
191/1685 (11.3%)
143/995 (14.4%)
Peripheral vascular disease — no./total no. (%)
248/1684 (14.7%)
320/995 (32.2%)
COPD — no./total no. (%)
Any — no./total no. (%)
327/1684 (19.4%)
218/995 (21.9%)
Oxygen-Dependent — no./total no. (%)
31/1684 (1.8%)
11/995 (1.1%)
Creatinine > 2 mg/dL (177 μmol/liter) — no./total no. (%)
104/1681 (6.2%)
114/994 (11.5%)
Atrial fibrillation — no./total no. (%)
395/1678 (23.5%)
289/990 (29.2%)
Permanent pacemaker — no./total no. (%)
170/1685 (10.1%)
134/995 (13.5%)
Pulmonary hypertension — no./total no. (%)
440/1684 (26.1%)
204/995 (20.5%)
Frailty
§
— no./total no. (%)
896/932 (96.1%)
548/579 (94.6%)
Extensively calcified aorta — no./total no. (%)
71/1684 (4.2%)
103/995 (10.4%)
Chest-wall deformity — no./total no. (%)
18/1684 (1.1%)
6/995 (0.6%)
Liver disease — no./total no. (%)
52/1685 (3.1%)
27/995 (2.7%)
Echocardiographic findings
Aortic-valve area — cm
2
0.7 ± 0.21
0.7 ± 0.21
Mean aortic-valve gradient — mmHg
49.2 ± 16.54
45.0 ± 15.43
Mean LVEF — %
55.1 ± 12.48
53.2 ± 12.50
Moderate or severe mitral regurgitation
**
— no./total no. (%)
345/1633 (21.1%)
174/976 (17.8%)
Note: Plus–minus values are means ± SD. To convert the value for creatinine to micromoles per liter, multiply by
88.4. AT denotes as treated population, CABG denotes coronary-artery bypass grafting, COPD chronic obstructive
pulmonary disease, LVEF left ventricular ejection fraction, NYHA New York Heart Association, PCI percutaneous
coronary intervention, and TAVR transcatheter aortic-valve implantation.
† The Society of Thoracic Surgeons (STS) score measures patient risk at the time of cardiovascular surgery on a
scale that ranges from 0% to 100%, with higher numbers indicating greater risk. An STS score higher than 10%
indicates very high surgical risk.
‡ The logistic European System for Cardiac Operative Risk Evaluation (EuroSCORE), which measures patient risk
at the time of cardiovascular surgery, is calculated with the use of a logistic-regression equation. Scores range
from 0% to 100%, with higher scores indicating greater risk. A logistic EuroSCORE higher than 20% indicates
very high surgical risk.
§ Frailty was determined by the surgeons according to prespecified criteria.
** Moderate or severe mitral regurgitation was defined as regurgitation of grade 3+ or higher.