C U B E 3 0 T O U C H - U S E R M A N U A L
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Rev 1.1 07/2018
The instrument is designed to have temperature correction enabled at all times;
it relates the results to a temperature of 18°C according to Manley’s
Nomogram. However, it is possible to de-select temperature correction
according to laboratory needs.
Manley’s Nomogram
Clinical significance of ESR
The erythrocyte sedimentation rate test measures the distance travelled by red
blood cells in autologous plasma over a certain period of time. In normal
conditions, red blood cells tend to move apart reciprocally due to the presence
of negative electric charge from the numerous residues of sialic acid present at
a membrane glycoprotein level. When the protein composition of plasma
changes with the production of “acute phase proteins” at a hepatic level,
following an inflammatory process or tissue damage, the bond of these proteins
(fibrinogen, immunoglobulins) with the surface of the red blood cells alters the
negative charge of the membrane potential (Z) and the red blood cells can
bind, forming a rouleaux pattern. These rouleauxed cells aggregate to form
microspheres of a uniform radius, which start to sediment when their density
exceeds that of plasma. The ESR value goes up in all cases where there is an
increase in acute phase proteins, in particular fibrinogen (which is considered
