M I N I - C U B E – U S E R M A N U A L
41/59 Rev 1.3 06/2018
CALCULATING THE DAS 28
Clinical significance of Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic inflammatory disorder of autoimmune
origin that affects the joints. Due to this disorder of the immune system,
antibodies attack the synovial membrane that internally lines all joints, and the
resulting inflammation slowly thickens and destroys the synovium. As the
disorder progresses, the cartilage and tissues of the joints are destroyed.
When advanced, Rheumatoid Arthritis affects the bone surface. Over time,
the body replaces the damaged tissues with new scar tissues that cause the
rigidity and deformation commonly found in rheumatoid arthritis. Typical
symptoms of the disorder include muscle weakness and anaemia, swelling
and pain of the joints, fatigue, weight loss and fever. Rheumatoid Arthritis
typically affects the joints symmetrically, i.e., both wrists, elbows or knees.
The cause of rheumatoid arthritis is still unknown, so it is not possible to
prevent its onset. Although, early diagnosis is very important in order to start
treatment early to effectively manage the disorder.
The importance of early diagnosis
Besides a thorough examination of the joints, the patient should have a full
examination and undergo a number of laboratory tests in order to make a
diagnosis. One of the first tests carried out for basic patient evaluation is the
Chapter
7
