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6

NOxBOX

® 

mobile Operating Manual

English

General Description

The NOxBOXmobile is used to control the 

pressure and flow of NO gas into a patient 

breathing circuit. The flow of NO gas is 

controlled by the user via the adjustable 

flow meter (See Fig.1, item G). When used 

in conjunction with a NOxBOXO

2

 monitor, a 

complete delivery and monitoring system is 

formed that allows the user to set the patient 

dose level and continuously monitor the dose 

gas at patient side. 

The NOxBOXmobile system is mounted to an 

epoxy coated, mild steel trolley designed to be 

situated close to the patient’s bedside ventilator.

The NOxBOXmobile system provides capacity 

for two NO supply cylinders, up to 20L water 

capacity, which when combined with the auto-

changeover system ensures uninterrupted 

delivery of NO is possible. When used correctly, 

this helps guard against sudden unexpected 

withdrawal from INO therapy. 

The system is fitted with stainless steel high-

pressure hoses that attach to the cylinders 

via suitable cylinder connectors (specific to 

individual region). These hoses are fitted with 

a safety-cord to restrain the hose in the event 

of a catastrophic pressure burst. Further safety 

control measures are provided by a pressure 

relief valve fitted after the first stage regulator, 

with a second pressure relief valve fitted after 

the second stage regulator.  

INO Therapy Monitor

The system trolley is provided with a shelf that 

allows a NOxBOXO

2

 monitor to be fixed to the 

system, providing the monitoring capability. 

Refer to the NOxBOXO

2

 manuals for safe use 

and maintenance. 

Environmental Alarms

Optional NOxAIR environmental gas detectors 

can be provided to warn personnel of any 

leaks in the NO supply. These portable alarms 

continuously monitor the atmosphere for NO 

or NO

2

 levels (depending on model), capable 

of measuring down to 0.1ppm. Each monitor 

has a set of alarms that can be set to ensure 

best-practice environmental monitoring. These 

alarms can be worn by an individual, positioned 

in the vicinity of the patient or left on the hooks 

provided on the NOxBOXmobile. Refer to the 

NOxAIR environmental gas detector manuals 

for safe use and maintenance. 

Note: The NOxAIR alarms are personal alarms, 

designed to alert staff in the immediate vicinity 

of the alarm. They are not designed to be heard 

from a long distance or from a different room.

NO Gas Cylinders

The NOxBOXmobile system is designed for 

use with a medical-grade gas mixture of NO 

balanced in Nitrogen (N

2

). The maximum 

recommended concentration for use is 

1000ppm NO. Bedfont Scientific do not provide 

therapeutic gas mixtures for INO therapy. 

Refer to the manufacturer’s labels regarding the 

concentration and precise mixture of the NO/

N

2

 gas.

Please refer to the manufacturer’s instructions 

on safe handling of the gas, gas cylinder and 

any additional gas handling equipment provided. 

All safety notices and warning should be read 

and understood prior to use. 

Warning: N

2

 gas is an asphyxiant, and care 

should be taken to understand that adding 

large quantities of N

2

 to the patient circuit may 

cause dilution of the oxygen content of the 

patient gases. It is recommended at all times 

during INO therapy to use a monitor such as the 

NOxBOXO

2

 that provides oxygen monitoring 

capability to maintain awareness of this 

phenomenon possibly occurring. 

Summary of Contents for NOxBOX mobile

Page 1: ...NOxBOX mobile breath analysis is the new blood test www bedfont com NOxBOX mobile with NOxBOX or NOxBOX O2 ...

Page 2: ......

Page 3: ...System Contents 5 6 Instrument Layout 5 7 General Description 6 8 Manual Handling 7 9 Maintenance 8 10 Commissioning 8 11 Installing a Gas Cylinder 9 12 Cylinder Changeover 10 13 Initial Purge 11 14 Connecting to a Patient Circuit 12 13 15 Decommissioning 14 16 Dose Calculation 15 17 Manual Bagging 16 18 Calibration 17 19 Spares 18 20 Specification 18 21 Warranty 19 22 Troubleshooting 20 21 ...

Page 4: ...nce and safety instructions included in this manual and any manuals supplied with the INO Therapy monitor being used Only trained and responsible personnel should work with or around this equipment To avoid serious injury pay attention to all precautionary labels attached to equipment cylinders containers and boxes prior to start up Do not remove or obscure any label If a label is missing becomes ...

Page 5: ...th atmospheric oxygen to form NO2 Nitrogen Dioxide NO2 NO reacts with atmospheric oxygen to produce NO2 the NO2 may react further with water to produce nitric and nitrous acid which can both be extremely corrosive The human lungs are a wet environment so inhalation of this extremely toxic gas can have severe effects and every reasonable measure should be made to minimise exposure to NO2 Current UK...

Page 6: ... cylinder pressure gauges B Changeover unit C NOxAIR NO2 environmental sensor D Single stage regulator E Outlet pressure gauge F Trolley G Low flow indicator H High flow indicator I NOxAIR NO environmental sensor J Spanner attached by chain System Contents E F G H I J A B C D A NOxBOXO2 monitoring instrument 1 NOxBOXO2 2 Water trap Also supplied with Mains power adapter Calibration screwdriver Bac...

Page 7: ...safe use and maintenance Environmental Alarms Optional NOxAIR environmental gas detectors can be provided to warn personnel of any leaks in the NO supply These portable alarms continuously monitor the atmosphere for NO or NO2 levels depending on model capable of measuring down to 0 1ppm Each monitor has a set of alarms that can be set to ensure best practice environmental monitoring These alarms c...

Page 8: ...lines or gas cylinders When in use and attached to the patient the NOxBOXmobile should be placed to avoid any tension within the connection lines to the patient circuit The system brakes should be applied to prevent accidental movement of the equipment which could cause lines to disconnect from the patient circuit or damage to any monitor connections Gas cylinders can be heavy Appropriate manual h...

Page 9: ...s If any evidence of contamination is noted clean the part again Do not immerse the system in cleaning fluids Do not use abrasive cleaning materials on the system as this may damage the protective finish or affect the legibility of control panel items NOTE If using with a NOxBOXO2 or NOxBOX monitor ensure the guidelines for cleaning these monitors are followed separately These monitors can be easi...

Page 10: ...platform Prior to connecting the cylinder Ensure the gas control valve is shut this should be the default position for the valve Any leaking unregulated gas should be very obvious Remove any safety caps from the threaded valve connection on the cylinder Cylinder connections vary depending on territory Refer to your local distributor for details on your connection type Figure 2 BS14 connector with ...

Page 11: ... of any connections in place to other systems e g patient circuit before moving the system to avoid stretching lines 2 Turn the auto changeover control so that the arrow is pointing at the new full supply cylinder i e away from the cylinder about to be replaced see Fig 4 where cylinder 2 is being changed This step is best practice if the control remains pointing at the empty cylinder when the supp...

Page 12: ...er 1 Turn on cylinder 1 by opening the cylinder valve carefully The Pressure 1 gauge dial should register the contents pressure of the cylinder See Fig 5 item A Ensure there is sufficient pressure in the cylinder to commence treatment A full cylinder is approximately 150 200 bar check with your supplier A cylinder is empty at 10 bar The outlet pressure gauge dial Fig 5 item E should read 2 bar Ope...

Page 13: ...6 Refer to the NOxBOXO2 monitor User Manual for correct set up of the monitor to patient circuit 4 The system is now ready to commence delivery of NO to the patient 5 Refer to the NOxBOXmobile Quick StartGuide QSG for dose setting tables An illustrated example is shown in Figure 6 for 1000ppm supply patient vent flow of 6L min desired dose of 15ppm the NO flow setting should be approx 90 cc min 6 ...

Page 14: ...ting required to achieve the desired dose Variations between ventilator set ups and individual systems may require slight adjustments e g 10 to this guideline flow rate to achieve the exact dose level If large adjustments are required to the guideline flow rate to achieve the dose rule out any system error with the equipment monitoring or delivery systems by following the troubleshooting actions i...

Page 15: ... materials 3 Connect the outlet of the NOxBOXmobile to a NOx scrubber filter or an appropriate atmospheric scavenger Contact Bedfont or your distributor for details of the NOx scrubber 4 Open the flow meter control until the NO flow reading is approximately 600 cc min Observe the inlet high pressure gauges Fig 8 A these will gradually decrease until the high pressure system is empty Then observe t...

Page 16: ...d patient dose of 4ppm the set NO flow cc min NO flow cc min 1000 x 5 5000 20 cc min 1000 4 1 249 NOTE the actual patient dose being delivered should always be confirmed by use of a continuous INO monitor designed for the purpose such as the NOxBOXO2 The guideline NO flow calculated using this formula should be considered as a guide value Fine tune the actual delivered dose by making an appropriat...

Page 17: ... regular patient ventilator circuit via the dose line exiting the left of the unit need to label this up Fig 9 This inserts into the circuit in the same location described within the Connect to Patient section page 12 The NO flow will be delivered normally through this dose line to the patient ventilator circuit when the control lever is turned such that the arrow points towards this dose line Ven...

Page 18: ...s equipment can only be undertaken by the original manufacturer These are safety critical devices and must not be tampered with as this could put patients at risk Pressure Regulators The pressure regulator performance should be checked and the output pressure verified as 2 bar All calibration repair or refurbishment of this equipment can only be undertaken by the original manufacturer These are sa...

Page 19: ...sensor for NOxBOXO2 NOXO2 NO2 Replacement NO2 sensor for NOxBOXO2 NOXO2 O2 Replacement O2 sensor for NOxBOXO2 NOXO2 NAF Nafion drying tube NOXO2WT COMPLETE Water trap FIX053 Power lead UK FIX054 Power lead EU NOX Y CAL Calibration system consisting of Y piece and male luer NOXKIT V Selection of connectors NO and O2 to vent NOXO2 FIL Bacterial filter CON139 Leur fitting for NOxBOXO2 CON136 Leur fit...

Page 20: ... of five years from the date of shipment Bedfont s sole obligation under this warranty is limited to repairing or replacing at its choice any item covered under this warranty when such item is returned intact prepaid to the factory The warranty does not apply to any products which have been repaired or altered by unauthorised persons or which have been subject to misuse negligence or accident ...

Page 21: ...ered to the patient WARNING sudden withdrawal from NO therapy can have severe effects on the patient including but not limited to hypoxic rebound Ensure that best practice is observed at all times to ensure the patient is not put at unnecessary risk If the above procedure cannot be followed for a quick system purge then the system must be purged through the flow meters This must be done without co...

Page 22: ... rises as expected but then there is a noticeable drop before the float rises again Why is this A The fine control valve on the flow meter may have been damaged by excessive opening of the valve control This can create deep scoring on the valve surface which affects the flow control performance across the flow range Please report to Bedfont or your distributor for corrective action Q Do Bedfont su...

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Page 24: ...te this literature without prior notice Registered office England and Wales Registered No 1289798 Station Road Harrietsham Maidstone Kent ME17 1JA England Tel 44 0 1622 851122 Fax 44 0 1622 854860 Email ask bedfont com www bedfont com Bedfont Scientific Ltd ISO 9001 2008 Cert No FM 31664 ISO 13485 2003 Cert No MD 502905 ...

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