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4
NOxBOX
®
mobile Operating Manual
English
Warnings
DANGER: Mishandling of pressurized process
equipment or gas cylinders can result in death,
serious injury, or property damage. Handle
pressurized equipment and cylinders with
extreme care and in accordance with the
manufacturer’s instructions.
DANGER: Both high-pressure connection
hoses should be correctly attached to the
NOxBOXmobile system at all times whilst the
system is pressurized.
DANGER: Poisonous gases can be fatal if
inhaled, even in very small quantities. Provide
adequate ventilation and appropriate personal
protective equipment (PPE).
This equipment contains poisonous gases.
The Threshold Limit Value (TLV) for each gas
refers, in general, to airborne concentrations
at or below which nearly all workers may be
repeatedly exposed without adverse effects.
The TLVs for the specialty gases used with this
equipment should be stated on the cylinder
body labels and the MSDSs (Material Safety
Data Sheets) for each gas.
Nitric Oxide (NO):
At room temperature and atmospheric pressure,
NO is a colourless, odourless, toxic, non-
flammable gas. It will readily combine with
atmospheric oxygen to form NO
2
.
Nitrogen Dioxide (NO
2
):
NO reacts with atmospheric oxygen to produce
NO
2
; the NO
2
may react further with water to
produce nitric and nitrous acid which can both
be extremely corrosive. The human lungs
are a wet environment, so inhalation of this
extremely toxic gas can have severe effects and
every reasonable measure should be made to
minimise exposure to NO
2
.
Current UK HSE guidelines recommend
following the Chemical Hazard Awareness
Notice (CHAN) for nitrogen oxides (including
NO and NO
2
) state that time weighted average
(TWA) over eight hours should not exceed
1ppm.
Nitrogen (N
2
):
Nitrogen gas is an asphyxiant. A major
component of air, it is colourless and odourless
at room temperature. Care should be taken to
avoid excessive release of Nitrogen into the
atmosphere without adequate ventilation to
protect the user from a low-oxygen atmosphere
being created.
Contraindications
●
Refer to your NO drug manufacturer’s
instructions for use, safety and warning
statements regarding contraindications for
the application of nitric oxide gas for the
purpose of INO therapy.
●
NO gas is toxic at high concentrations and
appropriate continuous monitoring of the
applied patient dose concentration should
be used.
●
WARNING: Sudden cessation of INO
therapy can cause complications such as
rebound hypoxia to occur.
