3Brain BioCAM X, User Manual

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10
BioChip
The BioChip cartridge integrates on an electronic substrate the CMOS-MEA chip and a reservoir cham-
ber to maintain cultures or tissues contacting the electrode array either under cell culture media or per-
fused media, respectively. The cartridge is 54 mm x 54 mm (2-1/8 in x 2-1/8 in) in size and is conceived
to be placed in an incubator for cells or tissue cultures.
•
Contact pads: gold-plated pads for connection between the BioChip and the BioCAM X. Properly
cleaned and non-oxidized pads are needed for a stable connection.
•
PCB
: the printed circuit board substrate of the BioChip. Different colors are available and according to
the layout of the CMOS-MEA.
•
Glass ring
: borosilicate glass ring defining the reservoir. External diameter 28mm (1-7/64 in), internal
diameter 25mm (0-63/64 in), height 5mm (0-13/64 in).
•
Reservoir: chamber for the bath solution used for the biological preparation. The volume of solution
that can be contained is of about 2mL.
•
CMOS-MEA: chip integrating thousands of active electrodes for high-resolution electrophysiological
recordings from cells or tissues placed on its active area. Different application-specific MEA layouts
according to the BioChip model are available.
Contact pads
Glass ring
PCB
Reservoir
CMOS-MEA