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Material Data Safety Sheets

8-24

HP6A Manual

DMSO EXTRACT, IP-346 (WT.%): <3, for mineral oil only
NA=NOT APPLICABLE NE=NOT ESTABLISHED D=DECOMPOSES
FOR FURTHER TECHNICAL INFORMATION, CONTACT YOUR MARKETING REPRESENTATIVE

SECTION 10.

STABILITY AND REACTIVITY

STABILITY (THERMAL, LIGHT, ETC.): Stable.
CONDITIONS TO AVOID: Extreme heat and high energy sources of ignition.
INCOMPATIBILITY (MATERIALS TO AVOID): Strong oxidizers.
HAZARDOUS DECOMPOSITION PRODUCTS: Product does not decompose at ambient temperatures.
HAZARDOUS POLYMERIZATION: Will not occur.

SECTION 11.

TOXICOLOGICAL DATA

---ACUTE TOXICOLOGY---
ORAL  TOXICITY  (RATS):  Practically  non-toxic  (LD50:  greater than  2000  mg/kg).  ---Based  on  testing  of
similar products and/or the components.
DERMAL  TOXICITY  (RABBITS):  Practically  nontoxic  (LD50:  greater  than  2000  mg/kg).  ---Based  on
testing of similar products and/or the components.
INHALATION TOXICITY (RATS): Practically non-toxic (LC50: greater than 5 mg/l). ---Based on testing of
similar products and/or the components.
EYE  IRRITATION  (RABBITS):  Practically  nonirritating.  (Draize  score:  greater  than  6  but  15  or  less).  ---
Based on testing of similar products and/or the components.
SKIN IRRITATION (RABBITS): Practically nonirritating. (Primary Irritation Index: greater than 0.5 but less
than 3). ---Based on testing of similar products and/or the components.
OTHER  ACUTE  TOXICITY  DATA:  Although  an  acute  inhalation  study  was  not  performed  with  this
product,  a  variety  of  mineral  and  synthetic  oils,  such  as  those  in  this  product,  have  been  tested.  These
samples  had  virtually  no  effect  other  than  a  nonspecific  inflammatory  response  in  the  lung  to  the
aerosolized mineral oil. The presence of additives in other tested formulations (in approximately the same
amounts as in the present formulation) did not alter the observed effects.
---SUBCHRONIC  TOXICOLOGY  (SUMMARY)---  No  significant  adverse  effects  were  found  in  studies
using repeated dermal applications of similar formulations to the skin of laboratory animals for 13 weeks
at  doses  significantly  higher  than  those  expected  during  normal  industrial  exposure.  The  animals  were
evaluated  extensively  for  effects  of  exposure  (hematology,  serum  chemistry,  urinalysis,  organ  weights,
microscopic examination of tissues etc.).
---REPRODUCTIVE TOXICOLOGY (SUMMARY)---
No  teratogenic  effects  would  be  expected  from  dermal  exposure,  based  on  laboratory  developmental
toxicity studies of major components in this formulation and/or materials of similar composition.
---CHRONIC TOXICOLOGY (SUMMARY)---
Repeated  and/or  prolonged  exposure  may  cause  irritation  to  the  skin,  eyes  or  respiratory  tract.
Overexposure to oil mist may result in oil droplet deposition and/or granuloma formation. For mineral base
oils:  Base  oils  in  this  product  are  severely  solvent  refined  and/or  severely  hydrotreated.  Chronic  mouse
skin  painting  studies  of  severely  treated  oils  showed  no  evidence  of  carcinogenic  effects.  These  results
are  confirmed  on  a  continuing  basis  using  various  screening  methods  such  as  Modified  Ames  Test, IP-
346,  and/or  other  analytical  methods.  For  synthetic  base  oils:  The  base  oils  in  this  product  have  been
tested in  the  Ames assay  and  other tests of mutagenicity  with  negative results. These base oils are not
expected to be carcinogenic with chronic dermal exposures.
---SENSITIZATION (SUMMARY)---
Not expected to be sensitizing based on tests of this product, components, or similar products.