KrosFlo® TFDF™ Lab System
User Guide
41
repligen.com IF.UG.023 R1
10.
High Feed Flow Rate (FL-01) – Indicates a high flow rate which can shear cells.
11.
Low Feed Flow Rate (FL-01) – Indicates a low-flow issue which could rapidly foul the filter
due to insufficient crossflow.
12.
High Permeate Flow Rate (FL-02) – Indicates flux is too fast which could foul the filter.
13.
Low Permeate Flow Rate (FL-02) – Indicates flux is too low which could be indicative of a
fouled filter or obstruction in the permeate line.
Alarms have two categories:
1.
Warning Alarms
– These display as a flashing orange starburst approximately once per
second. A beep will also sound when an alarm setpoint is reached. The system will continue
to run if a warning alarm is triggered but will indicate active alarm.
2.
Shutdown Alarms
– These shut down the sequence, but not the full system. For example,
the recirculation/feed pump will stay on, the permeate pump will stop, and the diafiltration
pump will stop to maximize the opportunity to recover the run.
High alarms will trigger when the process value rises to the stored setpoint or above. Low alarms will
trigger when the process value falls to the stored setpoint or below. The system is equipped with a
short delay to avoid low alarms during startup conditions.
To modify an alarm threshold value, select the appropriate blue box in the Warning or Shutdown
Setpoint column and enter the desired value. Users can enable or disable an alarm by toggling the
grey
Warning Enable
or
Shutdown Enable
buttons.
If an alarm triggers, a red blinking Alarm Reset button will display in the bottom right corner of the
system screen and will remain until the issue is resolved. It can be cleared once the system is
operating below alarm conditions. Selecting the
Alarm Reset
button will silence the alarm and reset
the flashing button.
Figure 27. Alarm Reset button
