9. Safe handling of cooling fluids
10. Cooling Mixture Appendix
Cooled Carousel 12 Plus Reaction Station
Page 13
9.1 Use protective equipment and follow the instructions
The use of manual cooling mixtures offers considerable savings in time, convenience and
cost when compared with automatic chillers or cryostats. However, extreme care should be
taken when using cooling mixtures.
1. Cooling mixtures can unexpectedly spit and splash. Therefore it is important to cover all
exposed skin by wearing suitable protective gloves, aprons and face shield.
2. Do not initially fill the reservoir with solvent beyond the recommended depth as vigorous
bumping (splashing) can occur and solvent may be ejected from the reservoir. In partic-
ular, as the cooling mixture contacts the warmer surface of the tubes rapid evaporation
of CO
2
can occur, causing bubbling and spitting.
3. Take care when disposing of dry ice/acetone or other solvent mixtures! Do not attempt to
pour cold mixtures into containers that can be sealed. There is a danger of splashing and
pressure build up. Preferably allow the cooling mixture to warm to room temperature
before disposing of it according to appropriate local regulations
The following protective equipment is available from Radleys:
•
RR71505 - Cooling Protection Kit, includes
1 x RR99909 Cold Temp. Apron 1060mm long Waterproof
1 x RR99910 Protective Face Shield
1 x RR98024 Protective Cold Temperature Gloves
•
RR99909 - Cold Temp. Apron 1060mm long Waterproof
•
RR99910 - Protective Face Shield
•
RR98024 - Protective Cold Temperature Gloves
Dry Ice/Solvent Cooling Mixtures
Minimum
Flash Point
Inhalation
Skin
Explosive/
Solvent
Temperature (°C)
(°C)
Toxicity
Toxicity
Fire Hazard
Ethylene glycol
-15
110
low
low
low
Butyl ethyl ketone
-38
41
moderate
low
high
Acetonitrile
-42
5
high
high
high
Cyclohexanone
-46
46
moderate
low
moderate
Di(ethylene glycol) diethyl ether
-52
71
moderate
moderate
moderate
Ethanol
-72
8
low
low
high
Methanol
-78
11
high
high
high
Acetone
-78
-17
low
low
high
A Phipps & D N Hume J Chem Educ, 45, 664, 1968
Other Cooling Mixtures
Minimum
Temperature (°C)
Comments
Sodium chloride/ice
-21
33g salt/81g ice
Calcium chloride/ice
-40
100g salt/81g ice
