QF150S; edition 2016-05; page 7 of 19
2.6. Autoclave
For sterilization of the pump chamber we recommend the following steps.
1. CIP of the pump chamber according to 2.5 or any other suitable process
2. Empty the pump
3. Remove the pump chamber from the pump drive (see 4.1.1)
4. Close in and outlet of the pump e.g. by connecting hoses. Ensure that a free interchange of
gas and steam over a sterile barrier (e.g. sterile filter) at in- and outlet is available.
5. Autoclaving of the prepared pump chamber in a vacuum autoclave at max. 130°C (266°F) for
max. 30 min. Follow instructions of the autoclave manufacturer.
Please make sure that the pump chamber is not placed on the clamp ring during the
autoclave process. The clamp ring should not be loaded during autoclaving.
2.7. Steaming in place (SIP)
For steaming in place the pump chambers needs to be installed on the pump drive. During the
steaming process, the temperature in the pump must not exceed 130°C (266°F) and should not last
longer than 30 min. The cooling of the pump chamber should be against air.
Depending on the SIP
conditions it may be necessary to shorten the maintenance intervals for the elastomers significantly.
Tightening torques (4 Nm, 3 lb-ft)) of the front bolts of the pump chamber have to be verified after
each SIP cycle.
